Recent advances in molecular biomarkers for diabetes mellitus: a systematic review

Lees, T; Nassif, N; Simpson, A; Shad-Kaneez, F; Martiniello-Wilks, R; Lin, Y; Jones, A; Qu, X; Lal, S

Recent advances in molecular biomarkers for diabetes mellitus: a systematic review

Lees, T

Nassif, N

Simpson, A

Shad-Kaneez, F Martiniello-Wilks, R

Lin, Y

Jones, A

Qu, X Lal, S

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Publication Type:: Journal Article
Citation:: Biomarkers, 2017, 22 (7), pp. 604 - 613
Issue Date:: 2017-10-03

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Field	Value	Language
dc.contributor.author	Lees, T https://orcid.org/0000-0002-7321-2704	en_US
dc.contributor.author	Nassif, N https://orcid.org/0000-0003-2675-8322	en_US
dc.contributor.author	Simpson, A https://orcid.org/0000-0002-2249-5097	en_US
dc.contributor.author	Shad-Kaneez, F	en_US
dc.contributor.author	Martiniello-Wilks, R https://orcid.org/0000-0002-0038-3430	en_US
dc.contributor.author	Lin, Y https://orcid.org/0000-0002-4637-9701	en_US
dc.contributor.author	Jones, A https://orcid.org/0000-0002-3522-6371	en_US
dc.contributor.author	Qu, X	en_US
dc.contributor.author	Lal, S https://orcid.org/0000-0002-0911-0850	en_US
dc.date.available	2020-05-25T19:26:54Z
dc.date.issued	2017-10-03	en_US
dc.identifier.citation	Biomarkers, 2017, 22 (7), pp. 604 - 613	en_US
dc.identifier.issn	1354-750X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/100093
dc.description.abstract	© 2017 Informa UK Limited, trading as Taylor & Francis Group. Context: Diabetes is a growing global metabolic epidemic. Current research is focussing on exploring how the biological processes and clinical outcomes of diabetes are related and developing novel biomarkers to measure these relationships, as this can subsequently improve diagnostic, therapeutic and management capacity. Objective: The objective of this study is to identify the most recent advances in molecular biomarkers of diabetes and directions that warrant further research. Methods: Using a systematic search strategy, the MEDLINE, CINAHL and OVID MEDLINE databases were canvassed for articles that investigated molecular biomarkers for diabetes. Initial selections were made based on article title, whilst final inclusion was informed by a critical appraisal of the full text of each article. Results: The systematic search returned 246 records, of which 113 were unique. Following screening, 29 records were included in the final review. Three main research strategies (the development of novel technologies, broad biomarker panels, and targeted approaches) identified a number of potential biomarkers for diabetes including miR-126, C-reactive protein, 2-aminoadipic acid and betatrophin. Conclusion: The most promising research avenue identified is the detection and quantification of micro RNA. Further, the utilisation of functionalised electrodes as a means to detect biomarker compounds also warrants attention.	en_US
dc.relation.ispartof	Biomarkers	en_US
dc.relation.isbasedon	10.1080/1354750X.2017.1279216	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Diabetes Mellitus	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	Electrodes	en_US
dc.subject.mesh	Biomarkers	en_US
dc.title	Recent advances in molecular biomarkers for diabetes mellitus: a systematic review	en_US
dc.type	Journal Article
utslib.citation.volume	7	en_US
utslib.citation.volume	22	en_US
utslib.for	1002 Environmental Biotechnology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	7	en_US
pubs.publication-status	Published	en_US
pubs.volume	22	en_US

Abstract:

© 2017 Informa UK Limited, trading as Taylor & Francis Group. Context: Diabetes is a growing global metabolic epidemic. Current research is focussing on exploring how the biological processes and clinical outcomes of diabetes are related and developing novel biomarkers to measure these relationships, as this can subsequently improve diagnostic, therapeutic and management capacity. Objective: The objective of this study is to identify the most recent advances in molecular biomarkers of diabetes and directions that warrant further research. Methods: Using a systematic search strategy, the MEDLINE, CINAHL and OVID MEDLINE databases were canvassed for articles that investigated molecular biomarkers for diabetes. Initial selections were made based on article title, whilst final inclusion was informed by a critical appraisal of the full text of each article. Results: The systematic search returned 246 records, of which 113 were unique. Following screening, 29 records were included in the final review. Three main research strategies (the development of novel technologies, broad biomarker panels, and targeted approaches) identified a number of potential biomarkers for diabetes including miR-126, C-reactive protein, 2-aminoadipic acid and betatrophin. Conclusion: The most promising research avenue identified is the detection and quantification of micro RNA. Further, the utilisation of functionalised electrodes as a means to detect biomarker compounds also warrants attention.

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http://hdl.handle.net/10453/100093