Glutathione peroxidase 4: A new player in neurodegeneration?

Cardoso, BR; Hare, DJ; Bush, AI; Roberts, BR

Glutathione peroxidase 4: A new player in neurodegeneration?

Cardoso, BR Hare, DJ

Bush, AI Roberts, BR

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Publication Type:: Journal Article
Citation:: Molecular Psychiatry, 2017, 22 (3), pp. 328 - 335
Issue Date:: 2017-03-01

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Field	Value	Language
dc.contributor.author	Cardoso, BR	en_US
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Bush, AI	en_US
dc.contributor.author	Roberts, BR	en_US
dc.date.available	2020-05-25T19:04:03Z
dc.date.issued	2017-03-01	en_US
dc.identifier.citation	Molecular Psychiatry, 2017, 22 (3), pp. 328 - 335	en_US
dc.identifier.issn	1359-4184	en_US
dc.identifier.uri	http://hdl.handle.net/10453/101452
dc.description.abstract	© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was initially described in cancer cells and has since been identified in hippocampal and renal cells. In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration. In addition, we suggest that selenium deficiency enhances susceptibility to ferroptotic processes, as well as other programmed cell death pathways due to a reduction in GPx4 activity. We review recent studies of GPx4 with an emphasis on neuronal protection, and discuss the relevance of selenium levels on its enzymatic activity.	en_US
dc.relation	http://purl.org/au-research/grants/arc/LP140100095
dc.relation.ispartof	Molecular Psychiatry	en_US
dc.relation.isbasedon	10.1038/mp.2016.196	en_US
dc.subject.classification	Psychiatry	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Neurodegenerative Diseases	en_US
dc.subject.mesh	Selenium	en_US
dc.subject.mesh	Glutathione Peroxidase	en_US
dc.subject.mesh	Cell Death	en_US
dc.subject.mesh	Phospholipid Hydroperoxide Glutathione Peroxidase	en_US
dc.title	Glutathione peroxidase 4: A new player in neurodegeneration?	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	22	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
utslib.for	170102 Developmental Psychology and Ageing	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	22	en_US

Abstract:

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was initially described in cancer cells and has since been identified in hippocampal and renal cells. In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration. In addition, we suggest that selenium deficiency enhances susceptibility to ferroptotic processes, as well as other programmed cell death pathways due to a reduction in GPx4 activity. We review recent studies of GPx4 with an emphasis on neuronal protection, and discuss the relevance of selenium levels on its enzymatic activity.

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http://hdl.handle.net/10453/101452