Assessing the potential for trace organic contaminants commonly found in Australian rivers to induce vitellogenin in the native rainbowfish (Melanotaenia fluviatilis) and the introduced mosquitofish (Gambusia holbrooki)

Scott, PD; Coleman, HM; Colville, A; Lim, R; Matthews, B; McDonald, JA; Miranda, A; Neale, PA; Nugegoda, D; Tremblay, LA; Leusch, FDL

Assessing the potential for trace organic contaminants commonly found in Australian rivers to induce vitellogenin in the native rainbowfish (Melanotaenia fluviatilis) and the introduced mosquitofish (Gambusia holbrooki)

Scott, PD Coleman, HM Colville, A

Lim, R Matthews, B McDonald, JA Miranda, A Neale, PA Nugegoda, D Tremblay, LA Leusch, FDL

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Publication Type:: Journal Article
Citation:: Aquatic Toxicology, 2017, 185 pp. 105 - 120
Issue Date:: 2017-01-01

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Field	Value	Language
dc.contributor.author	Scott, PD	en_US
dc.contributor.author	Coleman, HM	en_US
dc.contributor.author	Colville, A https://orcid.org/0000-0002-6543-2539	en_US
dc.contributor.author	Lim, R	en_US
dc.contributor.author	Matthews, B	en_US
dc.contributor.author	McDonald, JA	en_US
dc.contributor.author	Miranda, A	en_US
dc.contributor.author	Neale, PA	en_US
dc.contributor.author	Nugegoda, D	en_US
dc.contributor.author	Tremblay, LA	en_US
dc.contributor.author	Leusch, FDL	en_US
dc.date.available	2017-02-06	en_US
dc.date.issued	2017-01-01	en_US
dc.identifier.citation	Aquatic Toxicology, 2017, 185 pp. 105 - 120	en_US
dc.identifier.issn	0166-445X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/114837
dc.description.abstract	© 2017 Elsevier B.V. In Australia, trace organic contaminants (TrOCs) and endocrine active compounds (EACs) have been detected in rivers impacted by sewage effluent, urban stormwater, agricultural and industrial inputs. It is unclear whether these chemicals are at concentrations that can elicit endocrine disruption in Australian fish species. In this study, native rainbowfish (Melanotaenia fluviatilis) and introduced invasive (but prevalent) mosquitofish (Gambusia holbrooki) were exposed to the individual compounds atrazine, estrone, bisphenol A, propylparaben and pyrimethanil, and mixtures of compounds including hormones and personal care products, industrial compounds, and pesticides at environmentally relevant concentrations. Vitellogenin (Vtg) protein and liver Vtg mRNA induction were used to assess the estrogenic potential of these compounds. Vtg expression was significantly affected in both species exposed to estrone at concentrations that leave little margin for safety (p < 0.001). Propylparaben caused a small but statistically significant 3× increase in Vtg protein levels (p = 0.035) in rainbowfish but at a concentration 40× higher than that measured in the environment, therefore propylparaben poses a low risk of inducing endocrine disruption in fish. Mixtures of pesticides and a mixture of hormones, pharmaceuticals, industrial compounds and pesticides induced a small but statistically significant increase in plasma Vtg in rainbowfish, but did not affect mosquitofish Vtg protein or mRNA expression. These results suggest that estrogenic activity represents a low risk to fish in most Australian rivers monitored to-date except for some species of fish at the most polluted sites.	en_US
dc.relation.ispartof	Aquatic Toxicology	en_US
dc.relation.isbasedon	10.1016/j.aquatox.2017.02.008	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Smegmamorpha	en_US
dc.subject.mesh	Cyprinodontiformes	en_US
dc.subject.mesh	Organic Chemicals	en_US
dc.subject.mesh	Vitellogenins	en_US
dc.subject.mesh	RNA, Messenger	en_US
dc.subject.mesh	Water Pollutants, Chemical	en_US
dc.subject.mesh	Rivers	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Introduced Species	en_US
dc.title	Assessing the potential for trace organic contaminants commonly found in Australian rivers to induce vitellogenin in the native rainbowfish (Melanotaenia fluviatilis) and the introduced mosquitofish (Gambusia holbrooki)	en_US
dc.type	Journal Article
utslib.citation.volume	185	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	05 Environmental Sciences	en_US
utslib.for	06 Biological Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	185	en_US

Abstract:

© 2017 Elsevier B.V. In Australia, trace organic contaminants (TrOCs) and endocrine active compounds (EACs) have been detected in rivers impacted by sewage effluent, urban stormwater, agricultural and industrial inputs. It is unclear whether these chemicals are at concentrations that can elicit endocrine disruption in Australian fish species. In this study, native rainbowfish (Melanotaenia fluviatilis) and introduced invasive (but prevalent) mosquitofish (Gambusia holbrooki) were exposed to the individual compounds atrazine, estrone, bisphenol A, propylparaben and pyrimethanil, and mixtures of compounds including hormones and personal care products, industrial compounds, and pesticides at environmentally relevant concentrations. Vitellogenin (Vtg) protein and liver Vtg mRNA induction were used to assess the estrogenic potential of these compounds. Vtg expression was significantly affected in both species exposed to estrone at concentrations that leave little margin for safety (p < 0.001). Propylparaben caused a small but statistically significant 3× increase in Vtg protein levels (p = 0.035) in rainbowfish but at a concentration 40× higher than that measured in the environment, therefore propylparaben poses a low risk of inducing endocrine disruption in fish. Mixtures of pesticides and a mixture of hormones, pharmaceuticals, industrial compounds and pesticides induced a small but statistically significant increase in plasma Vtg in rainbowfish, but did not affect mosquitofish Vtg protein or mRNA expression. These results suggest that estrogenic activity represents a low risk to fish in most Australian rivers monitored to-date except for some species of fish at the most polluted sites.

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http://hdl.handle.net/10453/114837