Association between hypertension and fragility fracture: A longitudinal study

Yang, S; Nguyen, ND; Center, JR; Eisman, JA; Nguyen, TV

Association between hypertension and fragility fracture: A longitudinal study

Yang, S Nguyen, ND Center, JR Eisman, JA Nguyen, TV

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Publication Type:: Journal Article
Citation:: Osteoporosis International, 2014, 25 (1), pp. 97 - 103
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Yang, S	en_US
dc.contributor.author	Nguyen, ND	en_US
dc.contributor.author	Center, JR	en_US
dc.contributor.author	Eisman, JA	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.available	2013-06-14	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Osteoporosis International, 2014, 25 (1), pp. 97 - 103	en_US
dc.identifier.issn	0937-941X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/116024
dc.description.abstract	Hypertension is an independent risk factor for osteoporosis and osteoporotic fracture in postmenopausal women. Introduction: Although hypertension has been suggested to be associated with increased fracture risk, it is not clear whether the association is independent of bone mineral density (BMD). The present study sought to examine the interrelationships between hypertension, BMD, and fracture risk. Methods: The study included 1,032 men and 1,701 women aged 50 years and older who were participants in the Dubbo Osteoporosis Epidemiology Study. BMD at the femoral neck and lumbar spine was measured by dual energy X-ray absorptiometry (GE-LUNAR Corp., Madison, WI, USA). The presence of hypertension was ascertained by direct interview and verification through clinical history. The incidence of fragility fractures was ascertained by X-ray report during the follow-up period (1989-2008). The Cox proportional hazards model was used to assess the association between hypertension and fracture risk. Results: Women with hypertension had lower BMD at the femoral neck (0.79 versus 0.82 g/cm2, P = 0.02) than those without the disease. After adjusting for BMD and covariates, hypertension was an independent risk factor for fragility fracture [hazard ratio (HR), 1.49; 95 % CI, 1.13-1.96]. In men, hypertension was associated with higher femoral neck BMD (0.94 versus 0.92 g/cm2, P = 0.02), but the association between hypertension and fracture risk did not reach statistical significance. Conclusion: Hypertension is associated with increased fracture risk in women, and the association is independent of BMD. © 2013 International Osteoporosis Foundation and National Osteoporosis Foundation.	en_US
dc.relation.ispartof	Osteoporosis International	en_US
dc.relation.isbasedon	10.1007/s00198-013-2457-8	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Femur Neck	en_US
dc.subject.mesh	Lumbar Vertebrae	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Osteoporosis	en_US
dc.subject.mesh	Osteoporosis, Postmenopausal	en_US
dc.subject.mesh	Hypertension	en_US
dc.subject.mesh	Absorptiometry, Photon	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Longitudinal Studies	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	New South Wales	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Kaplan-Meier Estimate	en_US
dc.subject.mesh	Osteoporotic Fractures	en_US
dc.title	Association between hypertension and fragility fracture: A longitudinal study	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	25	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	1117 Public Health and Health Services	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	25	en_US

Abstract:

Hypertension is an independent risk factor for osteoporosis and osteoporotic fracture in postmenopausal women. Introduction: Although hypertension has been suggested to be associated with increased fracture risk, it is not clear whether the association is independent of bone mineral density (BMD). The present study sought to examine the interrelationships between hypertension, BMD, and fracture risk. Methods: The study included 1,032 men and 1,701 women aged 50 years and older who were participants in the Dubbo Osteoporosis Epidemiology Study. BMD at the femoral neck and lumbar spine was measured by dual energy X-ray absorptiometry (GE-LUNAR Corp., Madison, WI, USA). The presence of hypertension was ascertained by direct interview and verification through clinical history. The incidence of fragility fractures was ascertained by X-ray report during the follow-up period (1989-2008). The Cox proportional hazards model was used to assess the association between hypertension and fracture risk. Results: Women with hypertension had lower BMD at the femoral neck (0.79 versus 0.82 g/cm2, P = 0.02) than those without the disease. After adjusting for BMD and covariates, hypertension was an independent risk factor for fragility fracture [hazard ratio (HR), 1.49; 95 % CI, 1.13-1.96]. In men, hypertension was associated with higher femoral neck BMD (0.94 versus 0.92 g/cm2, P = 0.02), but the association between hypertension and fracture risk did not reach statistical significance. Conclusion: Hypertension is associated with increased fracture risk in women, and the association is independent of BMD. © 2013 International Osteoporosis Foundation and National Osteoporosis Foundation.

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http://hdl.handle.net/10453/116024