Bulky Trichomonad Genomes: Encoding a Swiss Army Knife

Barratt, J; Gough, R; Stark, D; Ellis, J

Bulky Trichomonad Genomes: Encoding a Swiss Army Knife

Barratt, J

Gough, R Stark, D Ellis, J

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Publication Type:: Journal Article
Citation:: Trends in Parasitology, 2016, 32 (10), pp. 783 - 797
Issue Date:: 2016-10-01

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Field	Value	Language
dc.contributor.author	Barratt, J https://orcid.org/0000-0001-8711-2408	en_US
dc.contributor.author	Gough, R	en_US
dc.contributor.author	Stark, D	en_US
dc.contributor.author	Ellis, J https://orcid.org/0000-0001-7328-4831	en_US
dc.date.available	2016-05-24	en_US
dc.date.issued	2016-10-01	en_US
dc.identifier.citation	Trends in Parasitology, 2016, 32 (10), pp. 783 - 797	en_US
dc.identifier.issn	1471-4922	en_US
dc.identifier.uri	http://hdl.handle.net/10453/117812
dc.description.abstract	© 2016 Elsevier Ltd The trichomonads are a remarkably successful lineage of ancient, predominantly parasitic protozoa. Recent molecular analyses have revealed extensive duplication of certain genetic loci in trichomonads. Consequently, their genomes are exceptionally large compared to other parasitic protozoa. Retention of these large gene expansions across different trichomonad families raises the question: do these duplications afford an advantage? Many duplicated genes are linked to the parasitic lifestyle and some are regulated differently to their paralogues, suggesting they have acquired new functions. It is proposed that these large genomes encode a Swiss army knife of sorts, packed with a multitude of tools for use in many different circumstances. This may have bestowed trichomonads with the extraordinary versatility that has undoubtedly contributed to their success.	en_US
dc.relation.ispartof	Trends in Parasitology	en_US
dc.relation.isbasedon	10.1016/j.pt.2016.05.014	en_US
dc.subject.classification	Mycology & Parasitology	en_US
dc.subject.mesh	Trichomonas	en_US
dc.subject.mesh	Evolution, Molecular	en_US
dc.subject.mesh	Gene Expression Regulation	en_US
dc.subject.mesh	Gene Duplication	en_US
dc.subject.mesh	Genome, Protozoan	en_US
dc.subject.mesh	Host-Parasite Interactions	en_US
dc.title	Bulky Trichomonad Genomes: Encoding a Swiss Army Knife	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.citation.volume	32	en_US
utslib.for	070708 Veterinary Parasitology	en_US
utslib.for	110803 Medical Parasitology	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	07 Agricultural and Veterinary Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	10	en_US
pubs.publication-status	Published	en_US
pubs.volume	32	en_US

Abstract:

© 2016 Elsevier Ltd The trichomonads are a remarkably successful lineage of ancient, predominantly parasitic protozoa. Recent molecular analyses have revealed extensive duplication of certain genetic loci in trichomonads. Consequently, their genomes are exceptionally large compared to other parasitic protozoa. Retention of these large gene expansions across different trichomonad families raises the question: do these duplications afford an advantage? Many duplicated genes are linked to the parasitic lifestyle and some are regulated differently to their paralogues, suggesting they have acquired new functions. It is proposed that these large genomes encode a Swiss army knife of sorts, packed with a multitude of tools for use in many different circumstances. This may have bestowed trichomonads with the extraordinary versatility that has undoubtedly contributed to their success.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/117812