Heritability of young- and old-onset ischaemic stroke

Bluher, A; Devan, WJ; Holliday, EG; Nalls, M; Parolo, S; Bione, S; Giese, AK; Boncoraglio, GB; Maguire, JM; Müller-Nurasyid, M; Gieger, C; Meschia, JF; Rosand, J; Rolfs, A; Kittner, SJ; Mitchell, BD; O'Connell, JR; Cheng, YC

Heritability of young- and old-onset ischaemic stroke

Bluher, A Devan, WJ Holliday, EG Nalls, M Parolo, S Bione, S Giese, AK Boncoraglio, GB Maguire, JM

Müller-Nurasyid, M Gieger, C Meschia, JF Rosand, J Rolfs, A Kittner, SJ Mitchell, BD O'Connell, JR Cheng, YC

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Publication Type:: Journal Article
Citation:: European Journal of Neurology, 2015, 22 (11), pp. 1488 - 1491
Issue Date:: 2015-11-01

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Field	Value	Language
dc.contributor.author	Bluher, A	en_US
dc.contributor.author	Devan, WJ	en_US
dc.contributor.author	Holliday, EG	en_US
dc.contributor.author	Nalls, M	en_US
dc.contributor.author	Parolo, S	en_US
dc.contributor.author	Bione, S	en_US
dc.contributor.author	Giese, AK	en_US
dc.contributor.author	Boncoraglio, GB	en_US
dc.contributor.author	Maguire, JM https://orcid.org/0000-0001-5722-8311	en_US
dc.contributor.author	Müller-Nurasyid, M	en_US
dc.contributor.author	Gieger, C	en_US
dc.contributor.author	Meschia, JF	en_US
dc.contributor.author	Rosand, J	en_US
dc.contributor.author	Rolfs, A	en_US
dc.contributor.author	Kittner, SJ	en_US
dc.contributor.author	Mitchell, BD	en_US
dc.contributor.author	O'Connell, JR	en_US
dc.contributor.author	Cheng, YC	en_US
dc.date.available	2015-07-06	en_US
dc.date.issued	2015-11-01	en_US
dc.identifier.citation	European Journal of Neurology, 2015, 22 (11), pp. 1488 - 1491	en_US
dc.identifier.issn	1351-5101	en_US
dc.identifier.uri	http://hdl.handle.net/10453/118707
dc.description.abstract	© 2015 European Academy of Neurology. Background and purpose: Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples. Methods: This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated separately for young-onset stroke and old-onset stroke (age ≥ 55 years). Results: Heritabilities for young-onset stroke and old-onset stroke were estimated at 42% (±8%, P < 0.001) and 34% (±10%, P < 0.001), respectively. Conclusions: Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant.	en_US
dc.relation.ispartof	European Journal of Neurology	en_US
dc.relation.isbasedon	10.1111/ene.12827	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Brain Ischemia	en_US
dc.subject.mesh	Genetic Predisposition to Disease	en_US
dc.subject.mesh	Risk	en_US
dc.subject.mesh	Age of Onset	en_US
dc.subject.mesh	Genotype	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	European Continental Ancestry Group	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Stroke	en_US
dc.title	Heritability of young- and old-onset ischaemic stroke	en_US
dc.type	Journal Article
utslib.citation.volume	11	en_US
utslib.citation.volume	22	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1109 Neurosciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Nursing
utslib.copyright.status	closed_access
pubs.issue	11	en_US
pubs.publication-status	Published	en_US
pubs.volume	22	en_US

Abstract:

© 2015 European Academy of Neurology. Background and purpose: Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples. Methods: This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated separately for young-onset stroke and old-onset stroke (age ≥ 55 years). Results: Heritabilities for young-onset stroke and old-onset stroke were estimated at 42% (±8%, P < 0.001) and 34% (±10%, P < 0.001), respectively. Conclusions: Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant.

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http://hdl.handle.net/10453/118707