Maternal L-carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke

Saad, S; Al-Odat, I; Chan, YL; McGrath, KC; Pollock, CA; Oliver, BG; Chen, H

Maternal L-carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke

Saad, S

Al-Odat, I Chan, YL

McGrath, KC

Pollock, CA Oliver, BG

Chen, H

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Publication Type:: Journal Article
Citation:: Clinical and Experimental Pharmacology and Physiology, 2018, 45 (7), pp. 694 - 703
Issue Date:: 2018-07-01

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Field	Value	Language
dc.contributor.author	Saad, S https://orcid.org/0000-0001-8067-8046	en_US
dc.contributor.author	Al-Odat, I	en_US
dc.contributor.author	Chan, YL https://orcid.org/0000-0002-9605-4200	en_US
dc.contributor.author	McGrath, KC https://orcid.org/0000-0002-6244-3929	en_US
dc.contributor.author	Pollock, CA	en_US
dc.contributor.author	Oliver, BG https://orcid.org/0000-0002-7122-9262	en_US
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752	en_US
dc.date.available	2020-05-25T19:05:06Z
dc.date.issued	2018-07-01	en_US
dc.identifier.citation	Clinical and Experimental Pharmacology and Physiology, 2018, 45 (7), pp. 694 - 703	en_US
dc.identifier.issn	0305-1870	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122107
dc.description.abstract	© 2018 John Wiley & Sons Australia, Ltd Sex differences in disease susceptibility due to maternal programming have been reported. We previously observed that maternal smoking induced renal disease and neurological changes are restricted to males, while both male and female offspring develop metabolic disorders. We have also found that maternal L-carnitine supplementation during gestation and lactation can significantly improve glucose intolerance and hyperlipidaemia in male offspring. This study aimed to determine whether such beneficial effects can also occur in female offspring. Balb/c female mice were exposed to cigarette smoke (SE) 6 weeks prior to gestation, during gestation and lactation. A subgroup of the SE dams was given L-carnitine (1.5 mmol/L in drinking water) during gestation and lactation. Female offspring were studied at 20 days (weaning) and 13 weeks (adulthood). Maternal smoking increased liver weight (%) and blood glucose levels at 20 days, as well as glucose intolerance and plasma triglycerides levels at adulthood (P <.05). The hepatic lipid metabolic marker adipose triglyceride lipase was downregulated in the SE offspring at 20 days (P <.05). At 13 weeks, the hepatic pro-inflammatory markers IL-1β and TNF-α mRNA expression were upregulated, while the anti-inflammatory marker IL-10 mRNA expression was downregulated in the SE offspring (P <.05). Liver fibrosis was apparent at 20 days and 13 weeks. Maternal L-carnitine supplementation either normalised or suppressed the detrimental effects induced by maternal smoke exposure (P <.05). We conclude that maternal L-carnitine supplementation improves metabolic parameters in the female offspring of SE dams.	en_US
dc.relation.ispartof	Clinical and Experimental Pharmacology and Physiology	en_US
dc.relation.isbasedon	10.1111/1440-1681.12921	en_US
dc.subject.classification	Physiology	en_US
dc.subject.mesh	Liver	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice, Inbred BALB C	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Fibrosis	en_US
dc.subject.mesh	Glucose	en_US
dc.subject.mesh	Carnitine	en_US
dc.subject.mesh	Maternal Exposure	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Dietary Supplements	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Lipid Metabolism	en_US
dc.subject.mesh	Biomarkers	en_US
dc.subject.mesh	Cigarette Smoking	en_US
dc.title	Maternal L-carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke	en_US
dc.type	Journal Article
utslib.citation.volume	7	en_US
utslib.citation.volume	45	en_US
utslib.for	0606 Physiology	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	1116 Medical Physiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	7	en_US
pubs.publication-status	Published	en_US
pubs.volume	45	en_US

Abstract:

© 2018 John Wiley & Sons Australia, Ltd Sex differences in disease susceptibility due to maternal programming have been reported. We previously observed that maternal smoking induced renal disease and neurological changes are restricted to males, while both male and female offspring develop metabolic disorders. We have also found that maternal L-carnitine supplementation during gestation and lactation can significantly improve glucose intolerance and hyperlipidaemia in male offspring. This study aimed to determine whether such beneficial effects can also occur in female offspring. Balb/c female mice were exposed to cigarette smoke (SE) 6 weeks prior to gestation, during gestation and lactation. A subgroup of the SE dams was given L-carnitine (1.5 mmol/L in drinking water) during gestation and lactation. Female offspring were studied at 20 days (weaning) and 13 weeks (adulthood). Maternal smoking increased liver weight (%) and blood glucose levels at 20 days, as well as glucose intolerance and plasma triglycerides levels at adulthood (P <.05). The hepatic lipid metabolic marker adipose triglyceride lipase was downregulated in the SE offspring at 20 days (P <.05). At 13 weeks, the hepatic pro-inflammatory markers IL-1β and TNF-α mRNA expression were upregulated, while the anti-inflammatory marker IL-10 mRNA expression was downregulated in the SE offspring (P <.05). Liver fibrosis was apparent at 20 days and 13 weeks. Maternal L-carnitine supplementation either normalised or suppressed the detrimental effects induced by maternal smoke exposure (P <.05). We conclude that maternal L-carnitine supplementation improves metabolic parameters in the female offspring of SE dams.

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http://hdl.handle.net/10453/122107