Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

Atarashi, K; Suda, W; Luo, C; Kawaguchi, T; Motoo, I; Narushima, S; Kiguchi, Y; Yasuma, K; Watanabe, E; Tanoue, T; Thaiss, CA; Sato, M; Toyooka, K; Said, HS; Yamagami, H; Rice, SA; Gevers, D; Johnson, RC; Segre, JA; Chen, K; Kolls, JK; Elinav, E; Morita, H; Xavier, RJ; Hattori, M; Honda, K

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

Atarashi, K Suda, W Luo, C Kawaguchi, T Motoo, I Narushima, S Kiguchi, Y Yasuma, K Watanabe, E Tanoue, T Thaiss, CA Sato, M Toyooka, K Said, HS Yamagami, H Rice, SA

Gevers, D Johnson, RC Segre, JA Chen, K Kolls, JK Elinav, E Morita, H Xavier, RJ Hattori, M Honda, K

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Publication Type:: Journal Article
Citation:: Science, 2017, 358 (6361), pp. 359 - 365
Issue Date:: 2017-10-20

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Field	Value	Language
dc.contributor.author	Atarashi, K	en_US
dc.contributor.author	Suda, W	en_US
dc.contributor.author	Luo, C	en_US
dc.contributor.author	Kawaguchi, T	en_US
dc.contributor.author	Motoo, I	en_US
dc.contributor.author	Narushima, S	en_US
dc.contributor.author	Kiguchi, Y	en_US
dc.contributor.author	Yasuma, K	en_US
dc.contributor.author	Watanabe, E	en_US
dc.contributor.author	Tanoue, T	en_US
dc.contributor.author	Thaiss, CA	en_US
dc.contributor.author	Sato, M	en_US
dc.contributor.author	Toyooka, K	en_US
dc.contributor.author	Said, HS	en_US
dc.contributor.author	Yamagami, H	en_US
dc.contributor.author	Rice, SA https://orcid.org/0000-0002-9486-2343	en_US
dc.contributor.author	Gevers, D	en_US
dc.contributor.author	Johnson, RC	en_US
dc.contributor.author	Segre, JA	en_US
dc.contributor.author	Chen, K	en_US
dc.contributor.author	Kolls, JK	en_US
dc.contributor.author	Elinav, E	en_US
dc.contributor.author	Morita, H	en_US
dc.contributor.author	Xavier, RJ	en_US
dc.contributor.author	Hattori, M	en_US
dc.contributor.author	Honda, K	en_US
dc.date.available	2017-09-07	en_US
dc.date.issued	2017-10-20	en_US
dc.identifier.citation	Science, 2017, 358 (6361), pp. 359 - 365	en_US
dc.identifier.issn	0036-8075	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122477
dc.description.abstract	Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.	en_US
dc.relation.ispartof	Science	en_US
dc.relation.isbasedon	10.1126/science.aan4526	en_US
dc.subject.classification	General Science & Technology	en_US
dc.subject.mesh	Mouth	en_US
dc.subject.mesh	Intestines	en_US
dc.subject.mesh	Th1 Cells	en_US
dc.subject.mesh	Saliva	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice, Inbred BALB C	en_US
dc.subject.mesh	Mice, Inbred C57BL	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Klebsiella	en_US
dc.subject.mesh	Inflammatory Bowel Diseases	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Drug Resistance, Bacterial	en_US
dc.subject.mesh	Germ-Free Life	en_US
dc.subject.mesh	Microbiota	en_US
dc.subject.mesh	Dysbiosis	en_US
dc.title	Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation	en_US
dc.type	Journal Article
utslib.citation.volume	6361	en_US
utslib.citation.volume	358	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	6361	en_US
pubs.publication-status	Published	en_US
pubs.volume	358	en_US

Abstract:

Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/122477