Brain derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) and nicotine

Machaalani, R; Chen, H

Brain derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) and nicotine

Machaalani, R Chen, H

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Publication Type:: Journal Article
Citation:: NeuroToxicology, 2018, 65 pp. 186 - 195
Issue Date:: 2018-03-01

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Field	Value	Language
dc.contributor.author	Machaalani, R	en_US
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752	en_US
dc.date.available	2020-05-25T19:10:40Z
dc.date.issued	2018-03-01	en_US
dc.identifier.citation	NeuroToxicology, 2018, 65 pp. 186 - 195	en_US
dc.identifier.issn	0161-813X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122789
dc.description.abstract	© 2018 Elsevier B.V. Nicotine is the major neurotoxicant in cigarettes that affects many transmitter systems within the brain as well as other factors, including the growth factors. Brain derived neurotrophic factor (BDNF), is the most abundant growth factor in the brain and plays a critical role in early new neuron differentiation, development and synapsis growth, and the survival of fully developed neurons and synaptic activity. Over the past 3 decades, data has emerged on the effects of nicotine and cigarette smoke exposure on the expression of BDNF and its primary specific receptor tyrosine kinase receptor B (TrkB). This review summarizes data regarding the changes in brain BDNF expression after nicotine or cigarette smoke exposure, and discusses their implications considering BDNF's functional roles.	en_US
dc.relation.ispartof	NeuroToxicology	en_US
dc.relation.isbasedon	10.1016/j.neuro.2018.02.014	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Nicotine	en_US
dc.subject.mesh	Receptor, trkB	en_US
dc.subject.mesh	Brain-Derived Neurotrophic Factor	en_US
dc.subject.mesh	Tobacco Smoke Pollution	en_US
dc.title	Brain derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) and nicotine	en_US
dc.type	Journal Article
utslib.citation.volume	65	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	65	en_US

Abstract:

© 2018 Elsevier B.V. Nicotine is the major neurotoxicant in cigarettes that affects many transmitter systems within the brain as well as other factors, including the growth factors. Brain derived neurotrophic factor (BDNF), is the most abundant growth factor in the brain and plays a critical role in early new neuron differentiation, development and synapsis growth, and the survival of fully developed neurons and synaptic activity. Over the past 3 decades, data has emerged on the effects of nicotine and cigarette smoke exposure on the expression of BDNF and its primary specific receptor tyrosine kinase receptor B (TrkB). This review summarizes data regarding the changes in brain BDNF expression after nicotine or cigarette smoke exposure, and discusses their implications considering BDNF's functional roles.

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http://hdl.handle.net/10453/122789