Quantitative bioimaging of Ca, Fe, Cu and Zn in breast cancer tissues by LA-ICP-MS

González De Vega, R; Fernández-Sánchez, ML; Pisonero, J; Eiró, N; Vizoso, FJ; Sanz-Medel, A

Quantitative bioimaging of Ca, Fe, Cu and Zn in breast cancer tissues by LA-ICP-MS

González De Vega, R

Fernández-Sánchez, ML Pisonero, J Eiró, N Vizoso, FJ Sanz-Medel, A

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Publication Type:: Journal Article
Citation:: Journal of Analytical Atomic Spectrometry, 2017, 32 (3), pp. 671 - 677
Issue Date:: 2017-03-01

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Field	Value	Language
dc.contributor.author	González De Vega, R https://orcid.org/0000-0002-9806-9633	en_US
dc.contributor.author	Fernández-Sánchez, ML	en_US
dc.contributor.author	Pisonero, J	en_US
dc.contributor.author	Eiró, N	en_US
dc.contributor.author	Vizoso, FJ	en_US
dc.contributor.author	Sanz-Medel, A	en_US
dc.date.issued	2017-03-01	en_US
dc.identifier.citation	Journal of Analytical Atomic Spectrometry, 2017, 32 (3), pp. 671 - 677	en_US
dc.identifier.issn	0267-9477	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125176
dc.description.abstract	© The Royal Society of Chemistry 2017. In recent years, several studies have shown that concentrations of essential trace elements naturally present in breast tissues (e.g. Ca, Fe, Cu and Zn) may be significantly increased in breast cancer tissues. This is not surprising because essential elements are responsible for a great number of metabolic and biological processes. The essential trace elements may play some major functions in life: stabilizers, elements of structure, elements for hormonal function and cofactors in enzymes. In any case, the role of trace elements in breast cancer is complex, because it affects many types of molecules, cells and tissues. The combination of analytical and immunehistochemical assays is crucial for better understanding of the role of essential trace elements in promoting tumor growth and migration. Bioimaging analytical techniques with adequate spatial resolution are today of crucial interest to investigate the spatial distribution of trace elements and correlate them with histological aspects in breast tissues. In this vein, in this particular study the application of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been used for the first time to investigate the actual distribution of the essential trace bioelements (Ca, Fe, Cu and Zn) in breast cancer tissues, and its possible application for tumor diagnostic and prognostic purposes. As has been demonstrated in this study, the levels of Ca, Fe, Cu and Zn in the tumor area are significantly higher than the levels found in the non-tumor one, as well as, a heterogeneous distribution of the investigated metals.	en_US
dc.relation.ispartof	Journal of Analytical Atomic Spectrometry	en_US
dc.relation.isbasedon	10.1039/c6ja00390g	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.title	Quantitative bioimaging of Ca, Fe, Cu and Zn in breast cancer tissues by LA-ICP-MS	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	32	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	0403 Geology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	32	en_US

Abstract:

© The Royal Society of Chemistry 2017. In recent years, several studies have shown that concentrations of essential trace elements naturally present in breast tissues (e.g. Ca, Fe, Cu and Zn) may be significantly increased in breast cancer tissues. This is not surprising because essential elements are responsible for a great number of metabolic and biological processes. The essential trace elements may play some major functions in life: stabilizers, elements of structure, elements for hormonal function and cofactors in enzymes. In any case, the role of trace elements in breast cancer is complex, because it affects many types of molecules, cells and tissues. The combination of analytical and immunehistochemical assays is crucial for better understanding of the role of essential trace elements in promoting tumor growth and migration. Bioimaging analytical techniques with adequate spatial resolution are today of crucial interest to investigate the spatial distribution of trace elements and correlate them with histological aspects in breast tissues. In this vein, in this particular study the application of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been used for the first time to investigate the actual distribution of the essential trace bioelements (Ca, Fe, Cu and Zn) in breast cancer tissues, and its possible application for tumor diagnostic and prognostic purposes. As has been demonstrated in this study, the levels of Ca, Fe, Cu and Zn in the tumor area are significantly higher than the levels found in the non-tumor one, as well as, a heterogeneous distribution of the investigated metals.

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http://hdl.handle.net/10453/125176