Quantitative Retinal Vascular Changes in Obstructive Sleep Apnea

Tong, JY; Golzan, M; Georgevsky, D; Williamson, JP; Graham, SL; Farah, CS; Fraser, CL

Quantitative Retinal Vascular Changes in Obstructive Sleep Apnea

Tong, JY Golzan, M

Georgevsky, D Williamson, JP Graham, SL Farah, CS Fraser, CL

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Publication Type:: Journal Article
Citation:: American Journal of Ophthalmology, 2017, 182 pp. 72 - 80
Issue Date:: 2017-10-01

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Field	Value	Language
dc.contributor.author	Tong, JY	en_US
dc.contributor.author	Golzan, M https://orcid.org/0000-0002-4479-3917	en_US
dc.contributor.author	Georgevsky, D	en_US
dc.contributor.author	Williamson, JP	en_US
dc.contributor.author	Graham, SL	en_US
dc.contributor.author	Farah, CS	en_US
dc.contributor.author	Fraser, CL	en_US
dc.date.available	2017-07-12	en_US
dc.date.issued	2017-10-01	en_US
dc.identifier.citation	American Journal of Ophthalmology, 2017, 182 pp. 72 - 80	en_US
dc.identifier.issn	0002-9394	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125321
dc.description.abstract	© 2017 Elsevier Inc. Purpose To examine the relationship between both static and dynamic retinal vascular caliber and the severity of obstructive sleep apnea (OSA). Design Prospective cross-sectional study. Methods Adult patients undergoing diagnostic polysomnography studies at a private Australian university teaching hospital were recruited. OSA severity was defined by the apnea-hypopnea index (AHI): severe >30, moderate >15–30, mild 5–15, and controls <5. Of 115 patients recruited (73 male; mean age 58 ± 13 years), there were 41 severe, 35 moderate, and 25 mild OSA patients and 14 controls. Static retinal vascular caliber was measured as the average diameter of retinal arterioles (CRAE) and venules (CRVE), and summarized as the arteriovenous ratio (AVR). Dynamic retinal vascular caliber was evaluated as the average pulsation amplitude of retinal arterioles (SRAP) and venules (SRVP). Comparisons across groups were performed using multivariate linear regression analysis. All results were adjusted for age, body mass index, and mean arterial pressure. Results Increasing AHI was significantly associated with decreasing AVR (P =.008) and CRAE (P =.016). A significant relationship was demonstrated between increasing AHI and attenuated retinal vascular pulsation amplitude (arterioles P =.028; venules P <.0001). Conclusions Increasing OSA severity is independently associated with retinal arteriolar narrowing and attenuated vascular pulsation amplitude. The retinal vasculature is easily imaged, and may be a surrogate biomarker of cerebral and systemic vascular risk in patients with OSA requiring further comprehensive investigation.	en_US
dc.relation.ispartof	American Journal of Ophthalmology	en_US
dc.relation.isbasedon	10.1016/j.ajo.2017.07.012	en_US
dc.subject.classification	Ophthalmology & Optometry	en_US
dc.subject.mesh	Arterioles	en_US
dc.subject.mesh	Retinal Artery	en_US
dc.subject.mesh	Venules	en_US
dc.subject.mesh	Retinal Vein	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Sleep Apnea, Obstructive	en_US
dc.subject.mesh	Retinal Diseases	en_US
dc.subject.mesh	Polysomnography	en_US
dc.subject.mesh	Body Mass Index	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Cross-Sectional Studies	en_US
dc.subject.mesh	Intraocular Pressure	en_US
dc.subject.mesh	Visual Acuity	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Arterial Pressure	en_US
dc.title	Quantitative Retinal Vascular Changes in Obstructive Sleep Apnea	en_US
dc.type	Journal Article
utslib.citation.volume	182	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1113 Opthalmology and Optometry	en_US
utslib.for	1117 Public Health and Health Services	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	182	en_US

Abstract:

© 2017 Elsevier Inc. Purpose To examine the relationship between both static and dynamic retinal vascular caliber and the severity of obstructive sleep apnea (OSA). Design Prospective cross-sectional study. Methods Adult patients undergoing diagnostic polysomnography studies at a private Australian university teaching hospital were recruited. OSA severity was defined by the apnea-hypopnea index (AHI): severe >30, moderate >15–30, mild 5–15, and controls <5. Of 115 patients recruited (73 male; mean age 58 ± 13 years), there were 41 severe, 35 moderate, and 25 mild OSA patients and 14 controls. Static retinal vascular caliber was measured as the average diameter of retinal arterioles (CRAE) and venules (CRVE), and summarized as the arteriovenous ratio (AVR). Dynamic retinal vascular caliber was evaluated as the average pulsation amplitude of retinal arterioles (SRAP) and venules (SRVP). Comparisons across groups were performed using multivariate linear regression analysis. All results were adjusted for age, body mass index, and mean arterial pressure. Results Increasing AHI was significantly associated with decreasing AVR (P =.008) and CRAE (P =.016). A significant relationship was demonstrated between increasing AHI and attenuated retinal vascular pulsation amplitude (arterioles P =.028; venules P <.0001). Conclusions Increasing OSA severity is independently associated with retinal arteriolar narrowing and attenuated vascular pulsation amplitude. The retinal vasculature is easily imaged, and may be a surrogate biomarker of cerebral and systemic vascular risk in patients with OSA requiring further comprehensive investigation.

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http://hdl.handle.net/10453/125321