Microstructural changes in the thalamus after mild traumatic brain injury: A longitudinal diffusion and mean kurtosis tensor MRI study

Næss-Schmidt, ET; Blicher, JU; Eskildsen, SF; Tietze, A; Hansen, B; Stubbs, PW; Jespersen, S; Østergaard, L; Nielsen, JF

Microstructural changes in the thalamus after mild traumatic brain injury: A longitudinal diffusion and mean kurtosis tensor MRI study

Næss-Schmidt, ET Blicher, JU

Eskildsen, SF Tietze, A Hansen, B Stubbs, PW

Jespersen, S Østergaard, L Nielsen, JF

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Publication Type:: Journal Article
Citation:: Brain Injury, 2017, 31 (2), pp. 230 - 236
Issue Date:: 2017-01-28

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Field	Value	Language
dc.contributor.author	Næss-Schmidt, ET	en_US
dc.contributor.author	Blicher, JU https://orcid.org/0000-0003-3443-4790	en_US
dc.contributor.author	Eskildsen, SF	en_US
dc.contributor.author	Tietze, A	en_US
dc.contributor.author	Hansen, B	en_US
dc.contributor.author	Stubbs, PW https://orcid.org/0000-0003-4555-8019	en_US
dc.contributor.author	Jespersen, S	en_US
dc.contributor.author	Østergaard, L	en_US
dc.contributor.author	Nielsen, JF https://orcid.org/0000-0001-5339-171X	en_US
dc.date.issued	2017-01-28	en_US
dc.identifier.citation	Brain Injury, 2017, 31 (2), pp. 230 - 236	en_US
dc.identifier.issn	0269-9052	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125544
dc.description.abstract	© 2017 Taylor & Francis Group, LLC. Primary objective: The primary aim of this study was to assess microstructural changes in the thalamus, hippocampus and corpus callosum with a fast mean kurtosis tensor (MKT) technique, in the acute and sub-acute phase after mTBI. It was hypothesized that MKT would differ between baseline and follow-up in patients. The secondary aim was to relate diffusion measures to symptoms of mTBI. Research design: A longitudinal case-control study. Methods and procedures: Twenty-seven patients with mTBI and 27 age- and gender-matched healthy controls were enrolled in the study. Patients were scanned within 2 weeks and 3 months after mTBI, while the controls were scanned once. Main outcomes and results: MKT decreased significantly (p = 0.02) from baseline to follow-up in the thalamus in patients. Compared to healthy subjects, thalamic MKT values were significantly larger in patients at baseline (p = 0.048). Secondary analysis revealed a significant decrease (p = 0.01) in fractional anisotropy in the splenium of corpus callosum from baseline to follow-up. Conclusions: The current study indicates microstructural changes in the thalamus and corpus callosum from within 14 days to 3 months after mTBI and suggests MKT as a potential biomarker after mTBI.	en_US
dc.relation.ispartof	Brain Injury	en_US
dc.relation.isbasedon	10.1080/02699052.2016.1229034	en_US
dc.subject.classification	Rehabilitation	en_US
dc.subject.mesh	Hippocampus	en_US
dc.subject.mesh	Thalamus	en_US
dc.subject.mesh	Corpus Callosum	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Brain Concussion	en_US
dc.subject.mesh	Diffusion Magnetic Resonance Imaging	en_US
dc.subject.mesh	Case-Control Studies	en_US
dc.subject.mesh	Longitudinal Studies	en_US
dc.subject.mesh	Image Processing, Computer-Assisted	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Young Adult	en_US
dc.subject.mesh	Diffusion Tensor Imaging	en_US
dc.title	Microstructural changes in the thalamus after mild traumatic brain injury: A longitudinal diffusion and mean kurtosis tensor MRI study	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	31	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1702 Cognitive Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	31	en_US

Abstract:

© 2017 Taylor & Francis Group, LLC. Primary objective: The primary aim of this study was to assess microstructural changes in the thalamus, hippocampus and corpus callosum with a fast mean kurtosis tensor (MKT) technique, in the acute and sub-acute phase after mTBI. It was hypothesized that MKT would differ between baseline and follow-up in patients. The secondary aim was to relate diffusion measures to symptoms of mTBI. Research design: A longitudinal case-control study. Methods and procedures: Twenty-seven patients with mTBI and 27 age- and gender-matched healthy controls were enrolled in the study. Patients were scanned within 2 weeks and 3 months after mTBI, while the controls were scanned once. Main outcomes and results: MKT decreased significantly (p = 0.02) from baseline to follow-up in the thalamus in patients. Compared to healthy subjects, thalamic MKT values were significantly larger in patients at baseline (p = 0.048). Secondary analysis revealed a significant decrease (p = 0.01) in fractional anisotropy in the splenium of corpus callosum from baseline to follow-up. Conclusions: The current study indicates microstructural changes in the thalamus and corpus callosum from within 14 days to 3 months after mTBI and suggests MKT as a potential biomarker after mTBI.

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http://hdl.handle.net/10453/125544