Does systemic administration of casein phosphopeptides affect orthodontic movement and root resorption in rats?

Crowther, L; Shen, G; Almuzian, M; Jones, A; Walsh, W; Oliver, R; Petocz, P; Tarraf, NE; Ali Darendeliler, M

Does systemic administration of casein phosphopeptides affect orthodontic movement and root resorption in rats?

Crowther, L Shen, G Almuzian, M Jones, A

Walsh, W Oliver, R Petocz, P Tarraf, NE Ali Darendeliler, M

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Publication Type:: Journal Article
Citation:: European Journal of Orthodontics, 2017, 39 (5), pp. 541 - 546
Issue Date:: 2017-10-01

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Field	Value	Language
dc.contributor.author	Crowther, L	en_US
dc.contributor.author	Shen, G	en_US
dc.contributor.author	Almuzian, M	en_US
dc.contributor.author	Jones, A https://orcid.org/0000-0002-3522-6371	en_US
dc.contributor.author	Walsh, W	en_US
dc.contributor.author	Oliver, R	en_US
dc.contributor.author	Petocz, P	en_US
dc.contributor.author	Tarraf, NE	en_US
dc.contributor.author	Ali Darendeliler, M	en_US
dc.date.issued	2017-10-01	en_US
dc.identifier.citation	European Journal of Orthodontics, 2017, 39 (5), pp. 541 - 546	en_US
dc.identifier.issn	0141-5387	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126075
dc.description.abstract	© 2017 The Author. Objectives: To assess the potential effects of casein phosphopeptides (CPPs) on orthodontically induced iatrogenic root resorption (OIIRR) and orthodontic teeth movement. Materials and methods: Forty Wistar rats (aged 11 weeks) were randomly divided into experimental group (EG; n = 20) that received a diet supplemented with CPP and control group (CG; n = 20) devoid of diet supplement. A 150 g force was applied using nickel titanium (NiTi) coil that was bonded on maxillary incisors and extended unilaterally to a maxillary frst molar. At Day 28, animals in both groups were euthanized. Volumetric assessment of root resorption craters and linear measurement of maxillary frst molars movement were blindly examined using a microcomputed tomography scan. Results: Nine rats were excluded from the experiment due to loss during general anesthesia or appliances' failure. Intra-operator reproducibility was high in both volumetric and linear measurements, 92.8 per cent and 98.5-97.6 per cent, respectively. The results reveal that dietary CPP has statistically insignifcant effect on the overall OIIRR and orthodontic movement. Conclusions: CPP seems to have statistically insignifcant effect on the volume of OIIRR and orthodontic movement in rats. A long-term study with larger sample size using a different concentration of CPP is required to clarify the dentoalveolar effect of CPP.	en_US
dc.relation.ispartof	European Journal of Orthodontics	en_US
dc.relation.isbasedon	10.1093/ejo/cjw085	en_US
dc.subject.classification	Dentistry	en_US
dc.subject.mesh	Incisor	en_US
dc.subject.mesh	Molar	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Rats, Wistar	en_US
dc.subject.mesh	Root Resorption	en_US
dc.subject.mesh	Alloys	en_US
dc.subject.mesh	Phosphopeptides	en_US
dc.subject.mesh	Caseins	en_US
dc.subject.mesh	Dental Alloys	en_US
dc.subject.mesh	Reproducibility of Results	en_US
dc.subject.mesh	Dietary Supplements	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	X-Ray Microtomography	en_US
dc.subject.mesh	Tooth Movement Techniques	en_US
dc.title	Does systemic administration of casein phosphopeptides affect orthodontic movement and root resorption in rats?	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	39	en_US
utslib.for	1105 Dentistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	39	en_US

Abstract:

© 2017 The Author. Objectives: To assess the potential effects of casein phosphopeptides (CPPs) on orthodontically induced iatrogenic root resorption (OIIRR) and orthodontic teeth movement. Materials and methods: Forty Wistar rats (aged 11 weeks) were randomly divided into experimental group (EG; n = 20) that received a diet supplemented with CPP and control group (CG; n = 20) devoid of diet supplement. A 150 g force was applied using nickel titanium (NiTi) coil that was bonded on maxillary incisors and extended unilaterally to a maxillary frst molar. At Day 28, animals in both groups were euthanized. Volumetric assessment of root resorption craters and linear measurement of maxillary frst molars movement were blindly examined using a microcomputed tomography scan. Results: Nine rats were excluded from the experiment due to loss during general anesthesia or appliances' failure. Intra-operator reproducibility was high in both volumetric and linear measurements, 92.8 per cent and 98.5-97.6 per cent, respectively. The results reveal that dietary CPP has statistically insignifcant effect on the overall OIIRR and orthodontic movement. Conclusions: CPP seems to have statistically insignifcant effect on the volume of OIIRR and orthodontic movement in rats. A long-term study with larger sample size using a different concentration of CPP is required to clarify the dentoalveolar effect of CPP.

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http://hdl.handle.net/10453/126075