Role of iron in the pathogenesis of respiratory disease

Ali, MK; Kim, RY; Karim, R; Mayall, JR; Martin, KL; Shahandeh, A; Abbasian, F; Starkey, MR; Loustaud-Ratti, V; Johnstone, D; Milward, EA; Hansbro, PM; Horvat, JC

Role of iron in the pathogenesis of respiratory disease

Ali, MK Kim, RY

Karim, R Mayall, JR Martin, KL Shahandeh, A Abbasian, F Starkey, MR Loustaud-Ratti, V Johnstone, D Milward, EA Hansbro, PM

Horvat, JC

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Publication Type:: Journal Article
Citation:: International Journal of Biochemistry and Cell Biology, 2017, 88 pp. 181 - 195
Issue Date:: 2017-07-01

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Field	Value	Language
dc.contributor.author	Ali, MK	en_US
dc.contributor.author	Kim, RY https://orcid.org/0000-0002-8709-5270	en_US
dc.contributor.author	Karim, R	en_US
dc.contributor.author	Mayall, JR	en_US
dc.contributor.author	Martin, KL	en_US
dc.contributor.author	Shahandeh, A	en_US
dc.contributor.author	Abbasian, F	en_US
dc.contributor.author	Starkey, MR	en_US
dc.contributor.author	Loustaud-Ratti, V	en_US
dc.contributor.author	Johnstone, D	en_US
dc.contributor.author	Milward, EA	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.contributor.author	Horvat, JC	en_US
dc.date.available	2017-05-03	en_US
dc.date.issued	2017-07-01	en_US
dc.identifier.citation	International Journal of Biochemistry and Cell Biology, 2017, 88 pp. 181 - 195	en_US
dc.identifier.issn	1357-2725	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126212
dc.description.abstract	© 2017 Elsevier Ltd Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. However, the mechanisms that underpin these associations and whether iron plays a key role in the pathogenesis of lung disease are yet to be fully elucidated. Furthermore, in order to survive and replicate, pathogenic micro-organisms have evolved strategies to source host iron, including freeing iron from cells and proteins that store and transport iron. To counter these microbial strategies, mammals have evolved immune-mediated defence mechanisms that reduce iron availability to pathogens. This interplay between iron, infection and immunity has important ramifications for the pathogenesis and management of human respiratory infections and diseases. An increased understanding of the role that iron plays in the pathogenesis of lung disease and respiratory infections may help inform novel therapeutic strategies. Here we review the clinical and experimental evidence that highlights the potential importance of iron in respiratory diseases and infections.	en_US
dc.relation.ispartof	International Journal of Biochemistry and Cell Biology	en_US
dc.relation.isbasedon	10.1016/j.biocel.2017.05.003	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Respiratory Tract Infections	en_US
dc.subject.mesh	Respiratory Tract Diseases	en_US
dc.subject.mesh	Iron	en_US
dc.subject.mesh	Homeostasis	en_US
dc.title	Role of iron in the pathogenesis of respiratory disease	en_US
dc.type	Journal Article
utslib.citation.volume	88	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
utslib.for	1116 Medical Physiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	88	en_US

Abstract:

© 2017 Elsevier Ltd Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. However, the mechanisms that underpin these associations and whether iron plays a key role in the pathogenesis of lung disease are yet to be fully elucidated. Furthermore, in order to survive and replicate, pathogenic micro-organisms have evolved strategies to source host iron, including freeing iron from cells and proteins that store and transport iron. To counter these microbial strategies, mammals have evolved immune-mediated defence mechanisms that reduce iron availability to pathogens. This interplay between iron, infection and immunity has important ramifications for the pathogenesis and management of human respiratory infections and diseases. An increased understanding of the role that iron plays in the pathogenesis of lung disease and respiratory infections may help inform novel therapeutic strategies. Here we review the clinical and experimental evidence that highlights the potential importance of iron in respiratory diseases and infections.

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http://hdl.handle.net/10453/126212