Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon

Bertram, MR; Delgado, A; Pauszek, SJ; Smoliga, GR; Brito, B; Stenfeldt, C; Hartwig, EJ; Jumbo, SD; Abdoulmoumini, M; Oliva Marie, AA; Salhine, R; Rodriguez, LL; Garabed, R; Arzt, J

Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon

Bertram, MR Delgado, A Pauszek, SJ Smoliga, GR Brito, B

Stenfeldt, C Hartwig, EJ Jumbo, SD Abdoulmoumini, M Oliva Marie, AA Salhine, R Rodriguez, LL Garabed, R Arzt, J

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Publication Type:: Journal Article
Citation:: Preventive Veterinary Medicine, 2018, 155 pp. 1 - 10
Issue Date:: 2018-07-01

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Field	Value	Language
dc.contributor.author	Bertram, MR	en_US
dc.contributor.author	Delgado, A	en_US
dc.contributor.author	Pauszek, SJ	en_US
dc.contributor.author	Smoliga, GR	en_US
dc.contributor.author	Brito, B https://orcid.org/0000-0001-6122-2596	en_US
dc.contributor.author	Stenfeldt, C	en_US
dc.contributor.author	Hartwig, EJ	en_US
dc.contributor.author	Jumbo, SD	en_US
dc.contributor.author	Abdoulmoumini, M	en_US
dc.contributor.author	Oliva Marie, AA	en_US
dc.contributor.author	Salhine, R	en_US
dc.contributor.author	Rodriguez, LL	en_US
dc.contributor.author	Garabed, R	en_US
dc.contributor.author	Arzt, J	en_US
dc.date.available	2018-04-04	en_US
dc.date.issued	2018-07-01	en_US
dc.identifier.citation	Preventive Veterinary Medicine, 2018, 155 pp. 1 - 10	en_US
dc.identifier.issn	0167-5877	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126524
dc.description.abstract	© 2018 Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under natural hyperendemic conditions in the Adamawa region of Cameroon. Vaccinated cattle (n = 50) and non-vaccinated controls (n = 100) were monitored by serum and oropharyngeal fluid (OPF) sample collection through a 12-month period. Anti-FMDV non-structural protein (anti-NSP) seroprevalence increased from 59.3% (89/150) at the beginning of the study to 85.8% (103/120) at the end of the study, and FMDV RNA was found in 28% (42/150) of animals overall, despite detection of clinical signs of FMD in only 6 non-vaccinated animals. Viral sequence analysis indicated that subclinical infections of FMDV serotypes O and A were present within the study herds during the study period, which was reflected by an overall increase of anti-NSP seroprevalence during the study. There was no association between vaccination status and seroconversion or prevalence of FMDV RNA in OPF. Younger cattle had higher odds of detection of FMDV RNA in OPF, but older animals were more likely to be seropositive. This study suggests vaccination of herds previously exposed to FMDV may help to limit clinical signs and reduce economic losses caused by FMDV. These findings also suggest that subclinical circulation of FMDV occurs in hyperendemic regions regardless of vaccination.	en_US
dc.relation.ispartof	Preventive Veterinary Medicine	en_US
dc.relation.isbasedon	10.1016/j.prevetmed.2018.04.003	en_US
dc.subject.classification	Veterinary Sciences	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Cattle	en_US
dc.subject.mesh	Foot-and-Mouth Disease Virus	en_US
dc.subject.mesh	Foot-and-Mouth Disease	en_US
dc.subject.mesh	Cattle Diseases	en_US
dc.subject.mesh	Viral Vaccines	en_US
dc.subject.mesh	Antibodies, Viral	en_US
dc.subject.mesh	Vaccination	en_US
dc.subject.mesh	Seroepidemiologic Studies	en_US
dc.subject.mesh	Cameroon	en_US
dc.title	Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon	en_US
dc.type	Journal Article
utslib.citation.volume	155	en_US
utslib.for	0707 Veterinary Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	155	en_US

Abstract:

© 2018 Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under natural hyperendemic conditions in the Adamawa region of Cameroon. Vaccinated cattle (n = 50) and non-vaccinated controls (n = 100) were monitored by serum and oropharyngeal fluid (OPF) sample collection through a 12-month period. Anti-FMDV non-structural protein (anti-NSP) seroprevalence increased from 59.3% (89/150) at the beginning of the study to 85.8% (103/120) at the end of the study, and FMDV RNA was found in 28% (42/150) of animals overall, despite detection of clinical signs of FMD in only 6 non-vaccinated animals. Viral sequence analysis indicated that subclinical infections of FMDV serotypes O and A were present within the study herds during the study period, which was reflected by an overall increase of anti-NSP seroprevalence during the study. There was no association between vaccination status and seroconversion or prevalence of FMDV RNA in OPF. Younger cattle had higher odds of detection of FMDV RNA in OPF, but older animals were more likely to be seropositive. This study suggests vaccination of herds previously exposed to FMDV may help to limit clinical signs and reduce economic losses caused by FMDV. These findings also suggest that subclinical circulation of FMDV occurs in hyperendemic regions regardless of vaccination.

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http://hdl.handle.net/10453/126524