Mechanisms of biofilm stimulation by subinhibitory concentrations of antimicrobials

Ranieri, MR; Whitchurch, CB; Burrows, LL

Mechanisms of biofilm stimulation by subinhibitory concentrations of antimicrobials

Ranieri, MR Whitchurch, CB

Burrows, LL

Permalink

Publication Type:: Journal Article
Citation:: Current Opinion in Microbiology, 2018, 45 pp. 164 - 169
Issue Date:: 2018-10-01

Closed Access

	Filename	Description	Size
	1-s2.0-S1369527418300237-main.pdf	Published Version	443.12 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Ranieri, MR	en_US
dc.contributor.author	Whitchurch, CB https://orcid.org/0000-0003-2296-3791	en_US
dc.contributor.author	Burrows, LL	en_US
dc.date.available	2018-07-11	en_US
dc.date.issued	2018-10-01	en_US
dc.identifier.citation	Current Opinion in Microbiology, 2018, 45 pp. 164 - 169	en_US
dc.identifier.issn	1369-5274	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126605
dc.description.abstract	© 2018 Elsevier Ltd Biofilms are a typical mode of growth for most microorganisms and provide them with a variety of survival benefits. Biofilms can pose medical and industrial challenges due to their increased tolerance of antimicrobials and disinfectants. Exposure of bacteria to subinhibitory concentrations of those compounds can further exacerbate the problem, as they provoke physiological changes that lead to increased biofilm production and potential therapeutic failure. The protected niche of a biofilm provides conditions that promote selection for persisters and resistant mutants. In this review we discuss our current understanding of the mechanisms underlying biofilm stimulation in response to subinhibitory antimicrobials, and how we might exploit this ‘anti-antibiotic’ phenotype to treat biofilm-related infections and discover new compounds.	en_US
dc.relation.ispartof	Current Opinion in Microbiology	en_US
dc.relation.isbasedon	10.1016/j.mib.2018.07.006	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Bacteria	en_US
dc.subject.mesh	Biofilms	en_US
dc.subject.mesh	Bacterial Infections	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Microbial Sensitivity Tests	en_US
dc.subject.mesh	Bacterial Physiological Phenomena	en_US
dc.title	Mechanisms of biofilm stimulation by subinhibitory concentrations of antimicrobials	en_US
dc.type	Journal Article
utslib.citation.volume	45	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	45	en_US

Abstract:

© 2018 Elsevier Ltd Biofilms are a typical mode of growth for most microorganisms and provide them with a variety of survival benefits. Biofilms can pose medical and industrial challenges due to their increased tolerance of antimicrobials and disinfectants. Exposure of bacteria to subinhibitory concentrations of those compounds can further exacerbate the problem, as they provoke physiological changes that lead to increased biofilm production and potential therapeutic failure. The protected niche of a biofilm provides conditions that promote selection for persisters and resistant mutants. In this review we discuss our current understanding of the mechanisms underlying biofilm stimulation in response to subinhibitory antimicrobials, and how we might exploit this ‘anti-antibiotic’ phenotype to treat biofilm-related infections and discover new compounds.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/126605