Electrospun nanosilicates-based organic/inorganic nanofibers for potential bone tissue engineering

Wang, Y; Cui, W; Chou, J; Wen, S; Sun, Y; Zhang, H

Electrospun nanosilicates-based organic/inorganic nanofibers for potential bone tissue engineering

Wang, Y Cui, W Chou, J

Wen, S Sun, Y

Zhang, H

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Publication Type:: Journal Article
Citation:: Colloids and Surfaces B: Biointerfaces, 2018, 172 pp. 90 - 97
Issue Date:: 2018-12-01

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Field	Value	Language
dc.contributor.author	Wang, Y	en_US
dc.contributor.author	Cui, W	en_US
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016	en_US
dc.contributor.author	Wen, S	en_US
dc.contributor.author	Sun, Y https://orcid.org/0000-0001-7642-1096	en_US
dc.contributor.author	Zhang, H	en_US
dc.date.available	2018-08-14	en_US
dc.date.issued	2018-12-01	en_US
dc.identifier.citation	Colloids and Surfaces B: Biointerfaces, 2018, 172 pp. 90 - 97	en_US
dc.identifier.issn	0927-7765	en_US
dc.identifier.uri	http://hdl.handle.net/10453/127390
dc.description.abstract	© 2018 Elsevier B.V. Although growth factors and drugs (BMP-2, dexamethasone, etc.) have been widely used for bone tissue engineering, they have unignored limits such as adverse effects at high concentrations and easy inactivation in vivo. Accordingly, more osteoinductive supplements without side effects should be considered as alternatives in the design of bone tissue engineering scaffolds. Nanosilicate is a bioactive inorganic nanomaterial consisting of hydrous sodium lithium magnesium silicate, which is recently found to be safe and effective for bone induction. In this study, a range of organic/inorganic nanofibrous scaffolds with varied nanosilicate concentrations (0%, 1%, 5%, and 10% w/w to PCL matrix) were successfully fabricated via electrospinning. The tensile properties of the nanofibers were enhanced at low nanosilicate concentrations, and the incorporation of nanosilicates had no influence on cytocompatibility. Besides, in vitro osteogenesis experiments showed that nanosilicates-doped nanofibers were capable of inducing bone formation better than pure PCL nanofiber samples. More importantly, the results of histological and immunohistochemical assessments further revealed that the nanosilicates-enriched nanofibers had a significant potential of ectopic bone formation in vivo, while the pure PCL samples only induced limited osteogenic cues. All these results indicate that the nanosilicates-based organic/inorganic nanofibers may be potentially efficient for bone tissue engineering.	en_US
dc.relation.ispartof	Colloids and Surfaces B: Biointerfaces	en_US
dc.relation.isbasedon	10.1016/j.colsurfb.2018.08.032	en_US
dc.subject.classification	Chemical Physics	en_US
dc.subject.mesh	Bone and Bones	en_US
dc.subject.mesh	Cell Line	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Inorganic Chemicals	en_US
dc.subject.mesh	Silicates	en_US
dc.subject.mesh	Organic Chemicals	en_US
dc.subject.mesh	Osteocalcin	en_US
dc.subject.mesh	Tissue Engineering	en_US
dc.subject.mesh	Temperature	en_US
dc.subject.mesh	Cell Differentiation	en_US
dc.subject.mesh	Osteogenesis	en_US
dc.subject.mesh	Tissue Scaffolds	en_US
dc.subject.mesh	Nanofibers	en_US
dc.title	Electrospun nanosilicates-based organic/inorganic nanofibers for potential bone tissue engineering	en_US
dc.type	Journal Article
utslib.citation.volume	172	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0904 Chemical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	172	en_US

Abstract:

© 2018 Elsevier B.V. Although growth factors and drugs (BMP-2, dexamethasone, etc.) have been widely used for bone tissue engineering, they have unignored limits such as adverse effects at high concentrations and easy inactivation in vivo. Accordingly, more osteoinductive supplements without side effects should be considered as alternatives in the design of bone tissue engineering scaffolds. Nanosilicate is a bioactive inorganic nanomaterial consisting of hydrous sodium lithium magnesium silicate, which is recently found to be safe and effective for bone induction. In this study, a range of organic/inorganic nanofibrous scaffolds with varied nanosilicate concentrations (0%, 1%, 5%, and 10% w/w to PCL matrix) were successfully fabricated via electrospinning. The tensile properties of the nanofibers were enhanced at low nanosilicate concentrations, and the incorporation of nanosilicates had no influence on cytocompatibility. Besides, in vitro osteogenesis experiments showed that nanosilicates-doped nanofibers were capable of inducing bone formation better than pure PCL nanofiber samples. More importantly, the results of histological and immunohistochemical assessments further revealed that the nanosilicates-enriched nanofibers had a significant potential of ectopic bone formation in vivo, while the pure PCL samples only induced limited osteogenic cues. All these results indicate that the nanosilicates-based organic/inorganic nanofibers may be potentially efficient for bone tissue engineering.

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http://hdl.handle.net/10453/127390