Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

Tonga, KO; King, GG; Farah, CS; Thamrin, C; Tang, FS; Santos, J; Sharma, P; Chapman, DG; Oliver, BG

Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

Tonga, KO King, GG Farah, CS Thamrin, C Tang, FS Santos, J

Sharma, P

Chapman, DG

Oliver, BG

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Publication Type:: Journal Article
Citation:: Respiratory Research, 2018, 19 (1)
Issue Date:: 2018-09-17

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Field	Value	Language
dc.contributor.author	Tonga, KO	en_US
dc.contributor.author	King, GG	en_US
dc.contributor.author	Farah, CS	en_US
dc.contributor.author	Thamrin, C	en_US
dc.contributor.author	Tang, FS	en_US
dc.contributor.author	Santos, J https://orcid.org/0000-0003-4067-220X	en_US
dc.contributor.author	Sharma, P https://orcid.org/0000-0002-2904-2306	en_US
dc.contributor.author	Chapman, DG https://orcid.org/0000-0002-8211-1817	en_US
dc.contributor.author	Oliver, BG https://orcid.org/0000-0002-7122-9262	en_US
dc.date.available	2018-09-05	en_US
dc.date.issued	2018-09-17	en_US
dc.identifier.citation	Respiratory Research, 2018, 19 (1)	en_US
dc.identifier.issn	1465-9921	en_US
dc.identifier.uri	http://hdl.handle.net/10453/128720
dc.description.abstract	© 2018 The Author(s). There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1026880
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1110368
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1104704
dc.relation.ispartof	Respiratory Research	en_US
dc.relation.isbasedon	10.1186/s12931-018-0880-2	en_US
dc.subject.classification	Respiratory System	en_US
dc.subject.mesh	Bronchoalveolar Lavage Fluid	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive	en_US
dc.subject.mesh	Inflammation	en_US
dc.subject.mesh	Adrenal Cortex Hormones	en_US
dc.subject.mesh	Respiratory Function Tests	en_US
dc.subject.mesh	Forced Expiratory Volume	en_US
dc.subject.mesh	Spirometry	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Cross-Sectional Studies	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Non-Smokers	en_US
dc.title	Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	19	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	19	en_US

Abstract:

© 2018 The Author(s). There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.

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http://hdl.handle.net/10453/128720