Implications of the diagnostic criteria of idiopathic pulmonary fibrosis in clinical practice: Analysis from the Australian Idiopathic Pulmonary Fibrosis Registry

Jo, HE; Glaspole, I; Goh, N; Hopkins, PMA; Moodley, Y; Reynolds, PN; Chapman, S; Walters, EH; Zappala, C; Allan, H; Macansh, S; Grainge, C; Keir, GJ; Hayen, A; Henderson, D; Klebe, S; Heinze, SB; Miller, A; Rouse, HC; Duhig, E; Cooper, WA; Mahar, AM; Ellis, S; McCormack, SR; Ng, B; Godbolt, DB; Corte, TJ

Implications of the diagnostic criteria of idiopathic pulmonary fibrosis in clinical practice: Analysis from the Australian Idiopathic Pulmonary Fibrosis Registry

Jo, HE Glaspole, I Goh, N Hopkins, PMA Moodley, Y Reynolds, PN Chapman, S Walters, EH Zappala, C Allan, H Macansh, S Grainge, C Keir, GJ Hayen, A

Henderson, D Klebe, S Heinze, SB Miller, A Rouse, HC Duhig, E Cooper, WA Mahar, AM Ellis, S McCormack, SR Ng, B Godbolt, DB Corte, TJ

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Publication Type:: Journal Article
Citation:: Respirology, 2019, 24 (4), pp. 361 - 368
Issue Date:: 2019-04-01

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Field	Value	Language
dc.contributor.author	Jo, HE	en_US
dc.contributor.author	Glaspole, I	en_US
dc.contributor.author	Goh, N	en_US
dc.contributor.author	Hopkins, PMA	en_US
dc.contributor.author	Moodley, Y	en_US
dc.contributor.author	Reynolds, PN	en_US
dc.contributor.author	Chapman, S	en_US
dc.contributor.author	Walters, EH	en_US
dc.contributor.author	Zappala, C	en_US
dc.contributor.author	Allan, H	en_US
dc.contributor.author	Macansh, S	en_US
dc.contributor.author	Grainge, C	en_US
dc.contributor.author	Keir, GJ	en_US
dc.contributor.author	Hayen, A https://orcid.org/0000-0003-4046-8030	en_US
dc.contributor.author	Henderson, D	en_US
dc.contributor.author	Klebe, S	en_US
dc.contributor.author	Heinze, SB	en_US
dc.contributor.author	Miller, A	en_US
dc.contributor.author	Rouse, HC	en_US
dc.contributor.author	Duhig, E	en_US
dc.contributor.author	Cooper, WA	en_US
dc.contributor.author	Mahar, AM	en_US
dc.contributor.author	Ellis, S	en_US
dc.contributor.author	McCormack, SR	en_US
dc.contributor.author	Ng, B	en_US
dc.contributor.author	Godbolt, DB	en_US
dc.contributor.author	Corte, TJ	en_US
dc.date.available	2018-09-23	en_US
dc.date.issued	2019-04-01	en_US
dc.identifier.citation	Respirology, 2019, 24 (4), pp. 361 - 368	en_US
dc.identifier.issn	1323-7799	en_US
dc.identifier.uri	http://hdl.handle.net/10453/129225
dc.description.abstract	© 2018 Asian Pacific Society of Respirology Background and objective: Current guidelines for the diagnosis of idiopathic pulmonary fibrosis (IPF) provide specific criteria for diagnosis in the setting of multidisciplinary discussion (MDD). We evaluate the utility and reproducibility of these diagnostic guidelines, using clinical data from the Australian IPF Registry. Methods: All patients enrolled in the registry undergo a diagnostic review whereby international IPF guidelines are applied via a registry MDD. We investigated the clinical applicability of these guidelines with regard to: (i) adherence to guidelines, (ii) Natural history of IPF diagnostic categories and (iii) Concordance for diagnostic features. Results: A total of 417 participants (69% male, 70.6 ± 8.0 years) with a clinical diagnosis of IPF underwent MDD. The 23% of participants who did not meet IPF diagnostic criteria displayed identical disease behaviour to those with confirmed IPF. Honeycombing on radiology was associated with a worse prognosis and this translated into poorer prognosis in the ‘definite’ IPF group. While there was moderate agreement for IPF diagnostic categories, agreement for specific radiological features, other than honeycombing, was poor. Conclusion: In clinical practice, physicians do not always follow IPF diagnostic guidelines. We demonstrate a cohort of IPF patients who do not meet IPF diagnostic guideline criteria, based largely on their radiology and lack of lung biopsy, but who have outcomes identical to those with IPF.	en_US
dc.relation.ispartof	Respirology	en_US
dc.relation.isbasedon	10.1111/resp.13427	en_US
dc.subject.classification	Respiratory System	en_US
dc.title	Implications of the diagnostic criteria of idiopathic pulmonary fibrosis in clinical practice: Analysis from the Australian Idiopathic Pulmonary Fibrosis Registry	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	24	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	24	en_US

Abstract:

© 2018 Asian Pacific Society of Respirology Background and objective: Current guidelines for the diagnosis of idiopathic pulmonary fibrosis (IPF) provide specific criteria for diagnosis in the setting of multidisciplinary discussion (MDD). We evaluate the utility and reproducibility of these diagnostic guidelines, using clinical data from the Australian IPF Registry. Methods: All patients enrolled in the registry undergo a diagnostic review whereby international IPF guidelines are applied via a registry MDD. We investigated the clinical applicability of these guidelines with regard to: (i) adherence to guidelines, (ii) Natural history of IPF diagnostic categories and (iii) Concordance for diagnostic features. Results: A total of 417 participants (69% male, 70.6 ± 8.0 years) with a clinical diagnosis of IPF underwent MDD. The 23% of participants who did not meet IPF diagnostic criteria displayed identical disease behaviour to those with confirmed IPF. Honeycombing on radiology was associated with a worse prognosis and this translated into poorer prognosis in the ‘definite’ IPF group. While there was moderate agreement for IPF diagnostic categories, agreement for specific radiological features, other than honeycombing, was poor. Conclusion: In clinical practice, physicians do not always follow IPF diagnostic guidelines. We demonstrate a cohort of IPF patients who do not meet IPF diagnostic guideline criteria, based largely on their radiology and lack of lung biopsy, but who have outcomes identical to those with IPF.

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http://hdl.handle.net/10453/129225