Analysis of amphetamine-type substances by capillary zone electrophoresis using capacitively coupled contactless conductivity detection

Epple, R; Blanes, L; Beavis, A; Roux, C; Doble, P

Analysis of amphetamine-type substances by capillary zone electrophoresis using capacitively coupled contactless conductivity detection

Epple, R Blanes, L Beavis, A

Roux, C

Doble, P

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Publication Type:: Journal Article
Citation:: Electrophoresis, 2010, 31 (15), pp. 2608 - 2613
Issue Date:: 2010-08-01

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Field	Value	Language
dc.contributor.author	Epple, R	en_US
dc.contributor.author	Blanes, L	en_US
dc.contributor.author	Beavis, A https://orcid.org/0000-0001-6259-7699	en_US
dc.contributor.author	Roux, C https://orcid.org/0000-0003-3610-420X	en_US
dc.contributor.author	Doble, P https://orcid.org/0000-0002-8472-1301	en_US
dc.date.issued	2010-08-01	en_US
dc.identifier.citation	Electrophoresis, 2010, 31 (15), pp. 2608 - 2613	en_US
dc.identifier.issn	0173-0835	en_US
dc.identifier.uri	http://hdl.handle.net/10453/13124
dc.description.abstract	CE with capacitively coupled contactless conductivity detection (C 4D) was employed for the separation and detection of seven amphetamine analogues as well as amphetamine, dextroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine. The separation electrolyte was 30 mM hydroxypropyl-β-cyclodextrin (HPβCD) in a 75 mM acetic acid+25 mM sodium acetate buffer adjusted to pH 4.55. Conductivity detection was compared with UV detection using this same electrolyte. Average detection limits for C 4D and UV were 1.3 and 1.0 ppm, respectively. The effects of HPβCD concentration and BGE composition on the selectivity of the separation were also investigated. An illicit, street-grade sample of 3,4-methylenedioxymethamphetamine (Ecstasy) and a prescription dextroamphetamine tablet were also analysed. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.	en_US
dc.relation.ispartof	Electrophoresis	en_US
dc.relation.isbasedon	10.1002/elps.201000128	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.subject.mesh	Amphetamines	en_US
dc.subject.mesh	Central Nervous System Stimulants	en_US
dc.subject.mesh	Electrophoresis, Capillary	en_US
dc.subject.mesh	Equipment Design	en_US
dc.subject.mesh	Electric Conductivity	en_US
dc.subject.mesh	Limit of Detection	en_US
dc.title	Analysis of amphetamine-type substances by capillary zone electrophoresis using capacitively coupled contactless conductivity detection	en_US
dc.type	Journal Article
utslib.citation.volume	15	en_US
utslib.citation.volume	31	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	0904 Chemical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.issue	15	en_US
pubs.publication-status	Published	en_US
pubs.volume	31	en_US

Abstract:

CE with capacitively coupled contactless conductivity detection (C 4D) was employed for the separation and detection of seven amphetamine analogues as well as amphetamine, dextroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine. The separation electrolyte was 30 mM hydroxypropyl-β-cyclodextrin (HPβCD) in a 75 mM acetic acid+25 mM sodium acetate buffer adjusted to pH 4.55. Conductivity detection was compared with UV detection using this same electrolyte. Average detection limits for C 4D and UV were 1.3 and 1.0 ppm, respectively. The effects of HPβCD concentration and BGE composition on the selectivity of the separation were also investigated. An illicit, street-grade sample of 3,4-methylenedioxymethamphetamine (Ecstasy) and a prescription dextroamphetamine tablet were also analysed. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

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http://hdl.handle.net/10453/13124