Optimally Hierarchical Nanostructured Hydroxyapatite Coatings for Superior Prosthesis Biointegration

Nasiri, N; Mukherjee, S; Panneerselvan, A; Nisbet, DR; Tricoli, A

Optimally Hierarchical Nanostructured Hydroxyapatite Coatings for Superior Prosthesis Biointegration

Nasiri, N

Mukherjee, S Panneerselvan, A Nisbet, DR Tricoli, A

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Publication Type:: Journal Article
Citation:: ACS Applied Materials and Interfaces, 2018, 10 (29), pp. 24840 - 24849
Issue Date:: 2018-07-25

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Field	Value	Language
dc.contributor.author	Nasiri, N https://orcid.org/0000-0003-4738-098X	en_US
dc.contributor.author	Mukherjee, S	en_US
dc.contributor.author	Panneerselvan, A	en_US
dc.contributor.author	Nisbet, DR	en_US
dc.contributor.author	Tricoli, A	en_US
dc.date.issued	2018-07-25	en_US
dc.identifier.citation	ACS Applied Materials and Interfaces, 2018, 10 (29), pp. 24840 - 24849	en_US
dc.identifier.issn	1944-8244	en_US
dc.identifier.uri	http://hdl.handle.net/10453/133945
dc.description.abstract	© 2018 American Chemical Society. Bone osteogenesis is a complex phenomenon dependent on numerous microenvironmental cues, with their synchrony regulating cellular functions, such as mechanical signaling, survival, proliferation, and differentiation, as well as controlled regional specification of skeletal progenitor cell fate. Therefore, obtaining a mechanistic understanding of cellular response to a microenvironment is now coming into intense focus, which will facilitate the design of programmable biomaterials for regenerative medicine. State-of-the-art nanomaterial synthesis and self-assembly processes yield complex structures that mimic surface properties, composition, and partially the morphology of the extracellular matrix. However, determining key structural properties that control cell attachment has been challenging and contradictory results are reported regarding the mechanisms and roll of nanostructured materials. Here, we significantly improve osteogenesis on bioinert substrates, demonstrating an exemplary organic-inorganic interface for superior prosthesis biointegration. We identify critical microscale hierarchical features that drastically enhance the cellular response to the same nanoscale architecture. It was observed that hierarchical morphologies, with a porosity above 80%, promote early-stage osteoinduction, as indicated by extensive coating ingrowth and nanofilopodia formation. We determined that cellular integration was mediated by two-way recognition of specific nano- and microtopographical cues between the host tissue and cellular microenvironment. This has allowed us to detail a set of determinant features for the nanofabrication of advanced prosthesis coatings that may ultimately improve implant longevity.	en_US
dc.relation.ispartof	ACS Applied Materials and Interfaces	en_US
dc.relation.isbasedon	10.1021/acsami.8b08029	en_US
dc.subject.classification	Nanoscience & Nanotechnology	en_US
dc.subject.mesh	Durapatite	en_US
dc.subject.mesh	Biocompatible Materials	en_US
dc.subject.mesh	Prostheses and Implants	en_US
dc.subject.mesh	Osteogenesis	en_US
dc.subject.mesh	Nanostructures	en_US
dc.title	Optimally Hierarchical Nanostructured Hydroxyapatite Coatings for Superior Prosthesis Biointegration	en_US
dc.type	Journal Article
utslib.citation.volume	29	en_US
utslib.citation.volume	10	en_US
utslib.for	0904 Chemical Engineering	en_US
utslib.for	0303 Macromolecular and Materials Chemistry	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	29	en_US
pubs.publication-status	Published	en_US
pubs.volume	10	en_US

Abstract:

© 2018 American Chemical Society. Bone osteogenesis is a complex phenomenon dependent on numerous microenvironmental cues, with their synchrony regulating cellular functions, such as mechanical signaling, survival, proliferation, and differentiation, as well as controlled regional specification of skeletal progenitor cell fate. Therefore, obtaining a mechanistic understanding of cellular response to a microenvironment is now coming into intense focus, which will facilitate the design of programmable biomaterials for regenerative medicine. State-of-the-art nanomaterial synthesis and self-assembly processes yield complex structures that mimic surface properties, composition, and partially the morphology of the extracellular matrix. However, determining key structural properties that control cell attachment has been challenging and contradictory results are reported regarding the mechanisms and roll of nanostructured materials. Here, we significantly improve osteogenesis on bioinert substrates, demonstrating an exemplary organic-inorganic interface for superior prosthesis biointegration. We identify critical microscale hierarchical features that drastically enhance the cellular response to the same nanoscale architecture. It was observed that hierarchical morphologies, with a porosity above 80%, promote early-stage osteoinduction, as indicated by extensive coating ingrowth and nanofilopodia formation. We determined that cellular integration was mediated by two-way recognition of specific nano- and microtopographical cues between the host tissue and cellular microenvironment. This has allowed us to detail a set of determinant features for the nanofabrication of advanced prosthesis coatings that may ultimately improve implant longevity.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/133945