The genetic basis of toxin biosynthesis in dinoflagellates

Verma, A; Barua, A; Ruvindy, R; Savela, H; Ajani, PA; Murray, SA

The genetic basis of toxin biosynthesis in dinoflagellates

Verma, A

Barua, A Ruvindy, R

Savela, H

Ajani, PA

Murray, SA

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Publication Type:: Journal Article
Citation:: Microorganisms, 2019, 7 (8)
Issue Date:: 2019-08-01

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Field	Value	Language
dc.contributor.author	Verma, A https://orcid.org/0000-0003-0119-9915	en_US
dc.contributor.author	Barua, A	en_US
dc.contributor.author	Ruvindy, R https://orcid.org/0000-0002-2031-9225	en_US
dc.contributor.author	Savela, H https://orcid.org/0000-0002-2058-2779	en_US
dc.contributor.author	Ajani, PA https://orcid.org/0000-0001-5364-9936	en_US
dc.contributor.author	Murray, SA https://orcid.org/0000-0001-7096-1307	en_US
dc.date.available	2019-07-27	en_US
dc.date.issued	2019-08-01	en_US
dc.identifier.citation	Microorganisms, 2019, 7 (8)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/135135
dc.description.abstract	© 2019 by the authors. Licensee MDPI, Basel, Switzerland. In marine ecosystems, dinoflagellates can become highly abundant and even dominant at times, despite their comparatively slow growth rates. One factor that may play a role in their ecological success is the production of complex secondary metabolite compounds that can have anti-predator, allelopathic, or other toxic effects on marine organisms, and also cause seafood poisoning in humans. Our knowledge about the genes involved in toxin biosynthesis in dinoflagellates is currently limited due to the complex genomic features of these organisms. Most recently, the sequencing of dinoflagellate transcriptomes has provided us with valuable insights into the biosynthesis of polyketide and alkaloid-based toxin molecules in dinoflagellate species. This review synthesizes the recent progress that has been made in understanding the evolution, biosynthetic pathways, and gene regulation in dinoflagellates with the aid of transcriptomic and other molecular genetic tools, and provides a pathway for future studies of dinoflagellates in this exciting omics era.	en_US
dc.relation	http://purl.org/au-research/grants/arc/FT120100704
dc.relation.ispartof	Microorganisms	en_US
dc.relation.isbasedon	10.3390/microorganisms7080222	en_US
dc.title	The genetic basis of toxin biosynthesis in dinoflagellates	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	7	en_US
utslib.for	0602 Ecology	en_US
utslib.for	0604 Genetics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - C3 - Climate Change Cluster
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	open_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. In marine ecosystems, dinoflagellates can become highly abundant and even dominant at times, despite their comparatively slow growth rates. One factor that may play a role in their ecological success is the production of complex secondary metabolite compounds that can have anti-predator, allelopathic, or other toxic effects on marine organisms, and also cause seafood poisoning in humans. Our knowledge about the genes involved in toxin biosynthesis in dinoflagellates is currently limited due to the complex genomic features of these organisms. Most recently, the sequencing of dinoflagellate transcriptomes has provided us with valuable insights into the biosynthesis of polyketide and alkaloid-based toxin molecules in dinoflagellate species. This review synthesizes the recent progress that has been made in understanding the evolution, biosynthetic pathways, and gene regulation in dinoflagellates with the aid of transcriptomic and other molecular genetic tools, and provides a pathway for future studies of dinoflagellates in this exciting omics era.

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http://hdl.handle.net/10453/135135