Soy intake and vasomotor menopausal symptoms among midlife women: a pooled analysis of five studies from the InterLACE consortium

Dunneram, Y; Chung, HF; Cade, JE; Greenwood, DC; Dobson, AJ; Mitchell, ES; Woods, NF; Brunner, EJ; Yoshizawa, T; Anderson, D; Mishra, GD

Soy intake and vasomotor menopausal symptoms among midlife women: a pooled analysis of five studies from the InterLACE consortium

Dunneram, Y Chung, HF Cade, JE Greenwood, DC Dobson, AJ Mitchell, ES Woods, NF Brunner, EJ Yoshizawa, T Anderson, D

Mishra, GD

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Publication Type:: Journal Article
Citation:: European Journal of Clinical Nutrition, 2019, 73 (11), pp. 1501 - 1511
Issue Date:: 2019-11-01

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Field	Value	Language
dc.contributor.author	Dunneram, Y	en_US
dc.contributor.author	Chung, HF	en_US
dc.contributor.author	Cade, JE	en_US
dc.contributor.author	Greenwood, DC	en_US
dc.contributor.author	Dobson, AJ	en_US
dc.contributor.author	Mitchell, ES	en_US
dc.contributor.author	Woods, NF	en_US
dc.contributor.author	Brunner, EJ	en_US
dc.contributor.author	Yoshizawa, T	en_US
dc.contributor.author	Anderson, D https://orcid.org/0000-0001-8996-9624	en_US
dc.contributor.author	Mishra, GD	en_US
dc.date.available	2020-05-25T19:05:39Z
dc.date.issued	2019-11-01	en_US
dc.identifier.citation	European Journal of Clinical Nutrition, 2019, 73 (11), pp. 1501 - 1511	en_US
dc.identifier.issn	0954-3007	en_US
dc.identifier.uri	http://hdl.handle.net/10453/137643
dc.description.abstract	© 2019, Springer Nature Limited. Background/objectives: Phytoestrogen rich-foods such as soy may be associated with less frequent/severe vasomotor menopausal symptoms (VMS), although evidence is limited. We thus investigated the associations between the consumption of soy products and soy milk and the frequency/severity of VMS. Subjects/methods: We pooled data from 19,351 middle-aged women from five observational studies in Australia, UK, USA, and Japan that contribute to the International Collaboration for a Life course Approach to reproductive health and Chronic disease Events (InterLACE). Information on soy consumption, VMS and covariates were collected by self-report. We included 11,006 women who had complete data on soy consumption, VMS and covariates at baseline for the cross-sectional analysis. For the prospective analysis, 4522 women who were free of VMS at baseline and had complete data on VMS at follow-up were considered. Multinomial logistic regression and binary logistic regression models were used. Results: No statistically significant evidence of an association was found between soy products (relative risk ratio (RRR): 0.92, 95% CI: 0.76–1.11) or soy milk (RRR: 1.24, 95% CI: 0.93–1.65) and the likelihood of reporting frequent or severe VMS cross-sectionally. Prospective results indicated that frequent consumption of soy products (odds ratio (OR): 0.63, 95% CI: 0.45–0.89) but not soy milk (OR: 1.11, 95% CI: 0.85–1.45) was associated with lower likelihood of reporting subsequent VMS, after adjustment for socio-demographic and reproductive factors. Conclusions: These are the first ever findings from pooled observational data of association between consumption of soy products and VMS.	en_US
dc.relation.ispartof	European Journal of Clinical Nutrition	en_US
dc.relation.isbasedon	10.1038/s41430-019-0398-9	en_US
dc.subject.classification	Nutrition & Dietetics	en_US
dc.title	Soy intake and vasomotor menopausal symptoms among midlife women: a pooled analysis of five studies from the InterLACE consortium	en_US
dc.type	Journal Article
utslib.citation.volume	11	en_US
utslib.citation.volume	73	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
utslib.for	1111 Nutrition and Dietetics	en_US
utslib.for	0908 Food Sciences	en_US
utslib.for	1106 Human Movement and Sports Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
pubs.issue	11	en_US
pubs.publication-status	Published	en_US
pubs.volume	73	en_US

Abstract:

© 2019, Springer Nature Limited. Background/objectives: Phytoestrogen rich-foods such as soy may be associated with less frequent/severe vasomotor menopausal symptoms (VMS), although evidence is limited. We thus investigated the associations between the consumption of soy products and soy milk and the frequency/severity of VMS. Subjects/methods: We pooled data from 19,351 middle-aged women from five observational studies in Australia, UK, USA, and Japan that contribute to the International Collaboration for a Life course Approach to reproductive health and Chronic disease Events (InterLACE). Information on soy consumption, VMS and covariates were collected by self-report. We included 11,006 women who had complete data on soy consumption, VMS and covariates at baseline for the cross-sectional analysis. For the prospective analysis, 4522 women who were free of VMS at baseline and had complete data on VMS at follow-up were considered. Multinomial logistic regression and binary logistic regression models were used. Results: No statistically significant evidence of an association was found between soy products (relative risk ratio (RRR): 0.92, 95% CI: 0.76–1.11) or soy milk (RRR: 1.24, 95% CI: 0.93–1.65) and the likelihood of reporting frequent or severe VMS cross-sectionally. Prospective results indicated that frequent consumption of soy products (odds ratio (OR): 0.63, 95% CI: 0.45–0.89) but not soy milk (OR: 1.11, 95% CI: 0.85–1.45) was associated with lower likelihood of reporting subsequent VMS, after adjustment for socio-demographic and reproductive factors. Conclusions: These are the first ever findings from pooled observational data of association between consumption of soy products and VMS.

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http://hdl.handle.net/10453/137643