Optimisation of monolithic nanocomposite and transparent ceramic scintillation detectors for positron emission tomography

Wilson, KJ; Alabd, R; Abolhasan, M; Safavi-Naeini, M; Franklin, DR

Optimisation of monolithic nanocomposite and transparent ceramic scintillation detectors for positron emission tomography

Wilson, KJ Alabd, R Abolhasan, M

Safavi-Naeini, M Franklin, DR

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Publication Type:: Journal Article
Citation:: Scientific Reports, 2020, 10 (1)
Issue Date:: 2020-12-01

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Field	Value	Language
dc.contributor.author	Wilson, KJ	en_US
dc.contributor.author	Alabd, R	en_US
dc.contributor.author	Abolhasan, M https://orcid.org/0000-0002-4282-6666	en_US
dc.contributor.author	Safavi-Naeini, M	en_US
dc.contributor.author	Franklin, DR https://orcid.org/0000-0002-9563-5943	en_US
dc.date.available	2019-12-17	en_US
dc.date.issued	2020-12-01	en_US
dc.identifier.citation	Scientific Reports, 2020, 10 (1)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138352
dc.description.abstract	© 2020, The Author(s). High-resolution arrays of discrete monocrystalline scintillators used for gamma photon coincidence detection in PET are costly and complex to fabricate, and exhibit intrinsically non-uniform sensitivity with respect to emission angle. Nanocomposites and transparent ceramics are two alternative classes of scintillator materials which can be formed into large monolithic structures, and which, when coupled to optical photodetector arrays, may offer a pathway to low cost, high-sensitivity, high-resolution PET. However, due to their high optical attenuation and scattering relative to monocrystalline scintillators, these materials exhibit an inherent trade-off between detection sensitivity and the number of scintillation photons which reach the optical photodetectors. In this work, a method for optimising scintillator thickness to maximise the probability of locating the point of interaction of 511 keV photons in a monolithic scintillator within a specified error bound is proposed and evaluated for five nanocomposite materials (LaBr3:Ce-polystyrene, Gd2O3-polyvinyl toluene, LaF3:Ce-polystyrene, LaF3:Ce-oleic acid and YAG:Ce-polystyrene) and four ceramics (GAGG:Ce, GLuGAG:Ce, GYGAG:Ce and LuAG:Pr). LaF3:Ce-polystyrene and GLuGAG:Ce were the best-performing nanocomposite and ceramic materials, respectively, with maximum sensitivities of 48.8% and 67.8% for 5 mm localisation accuracy with scintillator thicknesses of 42.6 mm and 27.5 mm, respectively.	en_US
dc.relation.ispartof	Scientific Reports	en_US
dc.relation.isbasedon	10.1038/s41598-020-58208-y	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Optimisation of monolithic nanocomposite and transparent ceramic scintillation detectors for positron emission tomography	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	10	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CRIN - Realtime Information Networks
pubs.organisational-group	/University of Technology Sydney/Strength - GBDTC - Global Big Data Technologies
utslib.copyright.status	open_access	*
pubs.issue	1	en_US
pubs.publication-status	Accepted	en_US
pubs.volume	10	en_US

Abstract:

© 2020, The Author(s). High-resolution arrays of discrete monocrystalline scintillators used for gamma photon coincidence detection in PET are costly and complex to fabricate, and exhibit intrinsically non-uniform sensitivity with respect to emission angle. Nanocomposites and transparent ceramics are two alternative classes of scintillator materials which can be formed into large monolithic structures, and which, when coupled to optical photodetector arrays, may offer a pathway to low cost, high-sensitivity, high-resolution PET. However, due to their high optical attenuation and scattering relative to monocrystalline scintillators, these materials exhibit an inherent trade-off between detection sensitivity and the number of scintillation photons which reach the optical photodetectors. In this work, a method for optimising scintillator thickness to maximise the probability of locating the point of interaction of 511 keV photons in a monolithic scintillator within a specified error bound is proposed and evaluated for five nanocomposite materials (LaBr3:Ce-polystyrene, Gd2O3-polyvinyl toluene, LaF3:Ce-polystyrene, LaF3:Ce-oleic acid and YAG:Ce-polystyrene) and four ceramics (GAGG:Ce, GLuGAG:Ce, GYGAG:Ce and LuAG:Pr). LaF3:Ce-polystyrene and GLuGAG:Ce were the best-performing nanocomposite and ceramic materials, respectively, with maximum sensitivities of 48.8% and 67.8% for 5 mm localisation accuracy with scintillator thicknesses of 42.6 mm and 27.5 mm, respectively.

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http://hdl.handle.net/10453/138352