Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy

Chacon, A; Guatelli, S; Rutherford, H; Bolst, D; Mohammadi, A; Ahmed, A; Nitta, M; Nishikido, F; Iwao, Y; Tashima, H; Yoshida, E; Akamatsu, G; Takyu, S; Kitagawa, A; Hofmann, T; Pinto, M; Franklin, DR; Parodi, K; Yamaya, T; Rosenfeld, A; Safavi-Naeini, M

Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy

Chacon, A Guatelli, S Rutherford, H Bolst, D Mohammadi, A Ahmed, A Nitta, M Nishikido, F Iwao, Y Tashima, H Yoshida, E Akamatsu, G Takyu, S Kitagawa, A Hofmann, T Pinto, M Franklin, DR

Parodi, K Yamaya, T Rosenfeld, A Safavi-Naeini, M

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Publication Type:: Journal Article
Citation:: Physics in Medicine and Biology, 2019, 64 (15)
Issue Date:: 2019-08-06

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Field	Value	Language
dc.contributor.author	Chacon, A	en_US
dc.contributor.author	Guatelli, S	en_US
dc.contributor.author	Rutherford, H	en_US
dc.contributor.author	Bolst, D	en_US
dc.contributor.author	Mohammadi, A	en_US
dc.contributor.author	Ahmed, A	en_US
dc.contributor.author	Nitta, M	en_US
dc.contributor.author	Nishikido, F	en_US
dc.contributor.author	Iwao, Y	en_US
dc.contributor.author	Tashima, H	en_US
dc.contributor.author	Yoshida, E	en_US
dc.contributor.author	Akamatsu, G	en_US
dc.contributor.author	Takyu, S	en_US
dc.contributor.author	Kitagawa, A	en_US
dc.contributor.author	Hofmann, T	en_US
dc.contributor.author	Pinto, M	en_US
dc.contributor.author	Franklin, DR https://orcid.org/0000-0002-9563-5943	en_US
dc.contributor.author	Parodi, K	en_US
dc.contributor.author	Yamaya, T	en_US
dc.contributor.author	Rosenfeld, A	en_US
dc.contributor.author	Safavi-Naeini, M	en_US
dc.date.available	2020-08-31T19:06:02Z
dc.date.issued	2019-08-06	en_US
dc.identifier.citation	Physics in Medicine and Biology, 2019, 64 (15)	en_US
dc.identifier.issn	0031-9155	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138356
dc.description.abstract	© 2019 Commonwealth of Australia, Australian Nuclear Science and Technology Organisation, ANSTO.. The distribution of fragmentation products predicted by Monte Carlo simulations of heavy ion therapy depend on the hadronic physics model chosen in the simulation. This work aims to evaluate three alternative hadronic inelastic fragmentation physics options available in the Geant4 Monte Carlo radiation physics simulation framework to determine which model most accurately predicts the production of positron-emitting fragmentation products observable using in-beam PET imaging. Fragment distributions obtained with the BIC, QMD, and INCL + + physics models in Geant4 version 10.2.p03 are compared to experimental data obtained at the HIMAC heavy-ion treatment facility at NIRS in Chiba, Japan. For both simulations and experiments, monoenergetic beams are applied to three different block phantoms composed of gelatin, poly(methyl methacrylate) and polyethylene. The yields of the positron-emitting nuclei 11C, 10C and 15O obtained from simulations conducted with each model are compared to the experimental yields estimated by fitting a multi-exponential radioactive decay model to dynamic PET images using the normalised mean square error metric in the entrance, build up/Bragg peak and tail regions. Significant differences in positron-emitting fragment yield are observed among the three physics models with the best overall fit to experimental 12C and 16O beam measurements obtained with the BIC physics model.	en_US
dc.relation.ispartof	Physics in Medicine and Biology	en_US
dc.relation.isbasedon	10.1088/1361-6560/ab2752	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Nuclear Medicine & Medical Imaging	en_US
dc.title	Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy	en_US
dc.type	Journal Article
utslib.citation.volume	15	en_US
utslib.citation.volume	64	en_US
utslib.for	0299 Other Physical Sciences	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CRIN - Realtime Information Networks
utslib.copyright.status	open_access	*
pubs.issue	15	en_US
pubs.publication-status	Published	en_US
pubs.volume	64	en_US

Abstract:

© 2019 Commonwealth of Australia, Australian Nuclear Science and Technology Organisation, ANSTO.. The distribution of fragmentation products predicted by Monte Carlo simulations of heavy ion therapy depend on the hadronic physics model chosen in the simulation. This work aims to evaluate three alternative hadronic inelastic fragmentation physics options available in the Geant4 Monte Carlo radiation physics simulation framework to determine which model most accurately predicts the production of positron-emitting fragmentation products observable using in-beam PET imaging. Fragment distributions obtained with the BIC, QMD, and INCL + + physics models in Geant4 version 10.2.p03 are compared to experimental data obtained at the HIMAC heavy-ion treatment facility at NIRS in Chiba, Japan. For both simulations and experiments, monoenergetic beams are applied to three different block phantoms composed of gelatin, poly(methyl methacrylate) and polyethylene. The yields of the positron-emitting nuclei 11C, 10C and 15O obtained from simulations conducted with each model are compared to the experimental yields estimated by fitting a multi-exponential radioactive decay model to dynamic PET images using the normalised mean square error metric in the entrance, build up/Bragg peak and tail regions. Significant differences in positron-emitting fragment yield are observed among the three physics models with the best overall fit to experimental 12C and 16O beam measurements obtained with the BIC physics model.

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http://hdl.handle.net/10453/138356