Salmonella genomic island 1 is broadly disseminated within gammaproteobacteriaceae

Cummins, ML; Hamidian, M; Djordjevic, SP

Salmonella genomic island 1 is broadly disseminated within gammaproteobacteriaceae

Cummins, ML

Hamidian, M

Djordjevic, SP

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Publication Type:: Journal Article
Citation:: Microorganisms, 2020, 8 (2)
Issue Date:: 2020-02-01

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Field	Value	Language
dc.contributor.author	Cummins, ML https://orcid.org/0000-0001-9333-7160	en_US
dc.contributor.author	Hamidian, M https://orcid.org/0000-0002-3614-7261	en_US
dc.contributor.author	Djordjevic, SP https://orcid.org/0000-0001-9301-5372	en_US
dc.date.available	2020-01-20	en_US
dc.date.issued	2020-02-01	en_US
dc.identifier.citation	Microorganisms, 2020, 8 (2)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138362
dc.description.abstract	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Salmonella genomic island 1 (SGI1) is an integrative mobilisable element that plays an important role in the capture and spread of multiple drug resistance. To date, SGI1 has been found in clinical isolates of Salmonella enterica serovars, Proteus mirabilis, Morganella morganii, Acinetobacter baumannii, Providencia stuartii, Enterobacter spp, and recently in Escherichia coli. SGI1 preferentially targets the 3´-end of trmE, a conserved gene found in the Enterobacteriaceae and among members of the Gammaproteobacteria. It is, therefore, hypothesised that SGI1 and SGI1‐related elements (SGI1-REs) may have been acquired by diverse bacterial genera. Here, Bitsliced Genomic Signature Indexes (BIGSI) was used to screen the NCBI Sequence Read Archive (SRA) for putative SGI1-REs in Gammaproteobacteria. Novel SGI‐REs were identified in diverse genera including Cronobacter spp, Klebsiella spp, and Vibrio spp and in two additional isolates of Escherichia coli. An extensively drug‐resistant human clonal lineage of Klebsiella pneumoniae carrying an SGI1‐RE in the United Kingdom and an SGI1-RE that lacks a class 1 integron were also identified. These findings provide insight into the origins of this diverse family of clinically important genomic islands and expand the knowledge of the potential host range of SGI1-REs within the Gammaproteobacteria.	en_US
dc.relation.ispartof	Microorganisms	en_US
dc.relation.isbasedon	10.3390/microorganisms8020161	en_US
dc.title	Salmonella genomic island 1 is broadly disseminated within gammaproteobacteriaceae	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	8	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	8	en_US

Abstract:

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Salmonella genomic island 1 (SGI1) is an integrative mobilisable element that plays an important role in the capture and spread of multiple drug resistance. To date, SGI1 has been found in clinical isolates of Salmonella enterica serovars, Proteus mirabilis, Morganella morganii, Acinetobacter baumannii, Providencia stuartii, Enterobacter spp, and recently in Escherichia coli. SGI1 preferentially targets the 3´-end of trmE, a conserved gene found in the Enterobacteriaceae and among members of the Gammaproteobacteria. It is, therefore, hypothesised that SGI1 and SGI1‐related elements (SGI1-REs) may have been acquired by diverse bacterial genera. Here, Bitsliced Genomic Signature Indexes (BIGSI) was used to screen the NCBI Sequence Read Archive (SRA) for putative SGI1-REs in Gammaproteobacteria. Novel SGI‐REs were identified in diverse genera including Cronobacter spp, Klebsiella spp, and Vibrio spp and in two additional isolates of Escherichia coli. An extensively drug‐resistant human clonal lineage of Klebsiella pneumoniae carrying an SGI1‐RE in the United Kingdom and an SGI1-RE that lacks a class 1 integron were also identified. These findings provide insight into the origins of this diverse family of clinically important genomic islands and expand the knowledge of the potential host range of SGI1-REs within the Gammaproteobacteria.

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http://hdl.handle.net/10453/138362