Epidural Spinal Cord Stimulation Improves Motor Function in Rats With Chemically Induced Parkinsonism

Zhong, H; Zhu, C; Minegishi, Y; Richter, F; Zdunowski, S; Roy, RR; Vissel, B; Gad, P; Gerasimenko, Y; Chesselet, MF; Edgerton, VR

Epidural Spinal Cord Stimulation Improves Motor Function in Rats With Chemically Induced Parkinsonism

Zhong, H Zhu, C Minegishi, Y Richter, F Zdunowski, S Roy, RR Vissel, B

Gad, P Gerasimenko, Y Chesselet, MF Edgerton, VR

Permalink

Publication Type:: Journal Article
Citation:: Neurorehabilitation and Neural Repair, 2019, 33 (12), pp. 1029 - 1039
Issue Date:: 2019-12-01

Closed Access

	Filename	Description	Size
	1545968319876891.pdf	Published Version	755.49 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Zhong, H	en_US
dc.contributor.author	Zhu, C	en_US
dc.contributor.author	Minegishi, Y	en_US
dc.contributor.author	Richter, F	en_US
dc.contributor.author	Zdunowski, S	en_US
dc.contributor.author	Roy, RR	en_US
dc.contributor.author	Vissel, B https://orcid.org/0000-0001-8860-8050	en_US
dc.contributor.author	Gad, P	en_US
dc.contributor.author	Gerasimenko, Y	en_US
dc.contributor.author	Chesselet, MF	en_US
dc.contributor.author	Edgerton, VR	en_US
dc.date.issued	2019-12-01	en_US
dc.identifier.citation	Neurorehabilitation and Neural Repair, 2019, 33 (12), pp. 1029 - 1039	en_US
dc.identifier.issn	1545-9683	en_US
dc.identifier.uri	http://hdl.handle.net/10453/139276
dc.description.abstract	© The Author(s) 2019. Background. Epidural stimulation of the spinal cord can reorganize and change the excitability of the neural circuitry to facilitate stepping in rats with a complete spinal cord injury. Parkinson’s disease results in abnormal supraspinal signals from the brain to the spinal cord that affect the functional capacity of the spinal networks. Objective. The objective was to determine whether epidural stimulation (electrical enabling motor control, eEmc) of the lumbosacral spinal cord can reorganize the spinal networks to facilitate hindlimb stepping of rats with parkinsonism. Methods. A unilateral 6-OHDA (6-hydroxydopamine) lesion of the nigrostriatal pathway was used to induce parkinsonism. Sham rats (N = 4) were injected in the same region with 0.1% of ascorbic acid. Stimulation electrodes were implanted epidurally at the L2 and S1 (N = 5) or L2 (N = 5) spinal levels. Results. The 6-OHDA rats showed severe parkinsonism in cylinder and adjusting step tests and were unable to initiate stepping when placed in a running wheel and dragged their toes on the affected side during treadmill stepping. During eEmc, the 6-OHDA rats initiated stepping in the running wheel and demonstrated improved stepping quality. Conclusion. Stepping was facilitated in rats with parkinsonism with spinal cord stimulation. The underlying assumption is that the normal functional capacity of spinal networks is affected by supraspinal pathology associated with Parkinson’s disease, which either generates insufficient or abnormal descending input to spinal networks and that eEmc can appropriately modulate spinal and supraspinal networks to improve the motor deficits.	en_US
dc.relation.ispartof	Neurorehabilitation and Neural Repair	en_US
dc.relation.isbasedon	10.1177/1545968319876891	en_US
dc.subject.classification	Rehabilitation	en_US
dc.title	Epidural Spinal Cord Stimulation Improves Motor Function in Rats With Chemically Induced Parkinsonism	en_US
dc.type	Journal Article
utslib.citation.volume	12	en_US
utslib.citation.volume	33	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1702 Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	12	en_US
pubs.publication-status	Published	en_US
pubs.volume	33	en_US

Abstract:

© The Author(s) 2019. Background. Epidural stimulation of the spinal cord can reorganize and change the excitability of the neural circuitry to facilitate stepping in rats with a complete spinal cord injury. Parkinson’s disease results in abnormal supraspinal signals from the brain to the spinal cord that affect the functional capacity of the spinal networks. Objective. The objective was to determine whether epidural stimulation (electrical enabling motor control, eEmc) of the lumbosacral spinal cord can reorganize the spinal networks to facilitate hindlimb stepping of rats with parkinsonism. Methods. A unilateral 6-OHDA (6-hydroxydopamine) lesion of the nigrostriatal pathway was used to induce parkinsonism. Sham rats (N = 4) were injected in the same region with 0.1% of ascorbic acid. Stimulation electrodes were implanted epidurally at the L2 and S1 (N = 5) or L2 (N = 5) spinal levels. Results. The 6-OHDA rats showed severe parkinsonism in cylinder and adjusting step tests and were unable to initiate stepping when placed in a running wheel and dragged their toes on the affected side during treadmill stepping. During eEmc, the 6-OHDA rats initiated stepping in the running wheel and demonstrated improved stepping quality. Conclusion. Stepping was facilitated in rats with parkinsonism with spinal cord stimulation. The underlying assumption is that the normal functional capacity of spinal networks is affected by supraspinal pathology associated with Parkinson’s disease, which either generates insufficient or abnormal descending input to spinal networks and that eEmc can appropriately modulate spinal and supraspinal networks to improve the motor deficits.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/139276