Design, synthesis, anti-mycobacterial and cytotoxic evaluation of C-4 functionalized 1,8-naphthalimide-heterocyclic hydrazide conjugates.

Shalini; Johansen, MD; Kremer, L; Kumar, V

Design, synthesis, anti-mycobacterial and cytotoxic evaluation of C-4 functionalized 1,8-naphthalimide-heterocyclic hydrazide conjugates.

Shalini Johansen, MD Kremer, L Kumar, V

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Chemical Biology and Drug Design, 2019, 94, (1), pp. 1300-1305
Issue Date:: 2019-07

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Field	Value	Language
dc.contributor.author	Shalini
dc.contributor.author	Johansen, MD
dc.contributor.author	Kremer, L
dc.contributor.author	Kumar, V
dc.date.accessioned	2020-05-20T23:42:56Z
dc.date.available	2019-02-09
dc.date.available	2020-05-20T23:42:56Z
dc.date.issued	2019-07
dc.identifier.citation	Chemical Biology and Drug Design, 2019, 94, (1), pp. 1300-1305
dc.identifier.issn	1747-0277
dc.identifier.issn	1747-0285
dc.identifier.uri	http://hdl.handle.net/10453/140854
dc.description.abstract	This manuscript discloses the design and synthesis of a series of C-4 functionalized 1,8-naphthalimide-heterocyclic hydrazide conjugates along with their anti-mycobacterial and cytotoxic evaluation. The present work assumes significance as it describes the first report on the amalgamation of C-4 substituted naphthalimides with various heterocyclic hydrazides. However, contrary to the rationale behind the synthesis of the conjugates, none of them inhibited the growth of Mycobacterium tuberculosis at the tested concentrations though these were non-cytotoxic towards the Vero kidney epithelial cell line.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Chemical Biology and Drug Design
dc.relation.isbasedon	10.1111/cbdd.13503
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Biophysics
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.title	Design, synthesis, anti-mycobacterial and cytotoxic evaluation of C-4 functionalized 1,8-naphthalimide-heterocyclic hydrazide conjugates.
dc.type	Journal Article
utslib.citation.volume	94
utslib.location.activity	England
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2020-05-20T23:42:45Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	94
utslib.start-page	1300
utslib.citation.issue	1

Abstract:

This manuscript discloses the design and synthesis of a series of C-4 functionalized 1,8-naphthalimide-heterocyclic hydrazide conjugates along with their anti-mycobacterial and cytotoxic evaluation. The present work assumes significance as it describes the first report on the amalgamation of C-4 substituted naphthalimides with various heterocyclic hydrazides. However, contrary to the rationale behind the synthesis of the conjugates, none of them inhibited the growth of Mycobacterium tuberculosis at the tested concentrations though these were non-cytotoxic towards the Vero kidney epithelial cell line.

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http://hdl.handle.net/10453/140854