Long-Term Exposure to Ambient Hydrocarbons Increases Dementia Risk in People Aged 50 Years and above in Taiwan.

Zhang, H-W; Kok, VC; Chuang, S-C; Tseng, C-H; Lin, C-T; Li, T-C; Sung, F-C; Wen, CP; Hsiung, CA; Hsu, CY

Long-Term Exposure to Ambient Hydrocarbons Increases Dementia Risk in People Aged 50 Years and above in Taiwan.

Zhang, H-W Kok, VC Chuang, S-C Tseng, C-H Lin, C-T Li, T-C Sung, F-C Wen, CP Hsiung, CA Hsu, CY

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Publisher:: Bentham Science Publishers Ltd.
Publication Type:: Journal Article
Citation:: Current Alzheimer research, 2019, 16, (14), pp. 1276-1289
Issue Date:: 2019-01

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Field	Value	Language
dc.contributor.author	Zhang, H-W
dc.contributor.author	Kok, VC
dc.contributor.author	Chuang, S-C
dc.contributor.author	Tseng, C-H
dc.contributor.author	Lin, C-T
dc.contributor.author	Li, T-C
dc.contributor.author	Sung, F-C
dc.contributor.author	Wen, CP
dc.contributor.author	Hsiung, CA
dc.contributor.author	Hsu, CY
dc.date.accessioned	2020-06-09T03:40:59Z
dc.date.available	2019-12-09
dc.date.available	2020-06-09T03:40:59Z
dc.date.issued	2019-01
dc.identifier.citation	Current Alzheimer research, 2019, 16, (14), pp. 1276-1289
dc.identifier.issn	1567-2050
dc.identifier.issn	1875-5828
dc.identifier.uri	http://hdl.handle.net/10453/141209
dc.description.abstract	BACKGROUND:Alzheimer's disease, the most common cause of dementia among the elderly, is a progressive and irreversible neurodegenerative disease. Exposure to air pollutants is known to have adverse effects on human health, however, little is known about hydrocarbons in the air that can trigger a dementia event. OBJECTIVE:We aimed to investigate whether long-term exposure to airborne hydrocarbons increases the risk of developing dementia. METHOD:The present cohort study included 178,085 people aged 50 years and older in Taiwan. Cox proportional hazards regression analysis was used to fit the multiple pollutant models for two targeted pollutants, including total hydrocarbons and non-methane hydrocarbons, and estimated the risk of dementia. RESULTS:Before controlling for multiple pollutants, hazard ratios with 95% confidence intervals for the overall population were 7.63 (7.28-7.99, p <0.001) at a 0.51-ppm increases in total hydrocarbons, and 2.94 (2.82-3.05, p <0.001) at a 0.32-ppm increases in non-methane hydrocarbons. The highest adjusted hazard ratios for different multiple-pollutant models of each targeted pollutant were statistically significant (p <0.001) for all patients: 11.52 (10.86-12.24) for total hydrocarbons and 9.73 (9.18-10.32) for non-methane hydrocarbons. CONCLUSION:Our findings suggest that total hydrocarbons and non-methane hydrocarbons may be contributing to dementia development.
dc.format	Print
dc.language	eng
dc.publisher	Bentham Science Publishers Ltd.
dc.relation.ispartof	Current Alzheimer research
dc.relation.isbasedon	10.2174/1567205017666200103112443
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1109 Neurosciences
dc.subject.classification	Neurology & Neurosurgery
dc.title	Long-Term Exposure to Ambient Hydrocarbons Increases Dementia Risk in People Aged 50 Years and above in Taiwan.
dc.type	Journal Article
utslib.citation.volume	16
utslib.location.activity	United Arab Emirates
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CAI - Centre for Artificial Intelligence
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Computer Science
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2020-06-09T03:40:56Z
pubs.issue	14
pubs.publication-status	Published
pubs.volume	16
utslib.start-page	1276
utslib.citation.issue	14

Abstract:

BACKGROUND:Alzheimer's disease, the most common cause of dementia among the elderly, is a progressive and irreversible neurodegenerative disease. Exposure to air pollutants is known to have adverse effects on human health, however, little is known about hydrocarbons in the air that can trigger a dementia event. OBJECTIVE:We aimed to investigate whether long-term exposure to airborne hydrocarbons increases the risk of developing dementia. METHOD:The present cohort study included 178,085 people aged 50 years and older in Taiwan. Cox proportional hazards regression analysis was used to fit the multiple pollutant models for two targeted pollutants, including total hydrocarbons and non-methane hydrocarbons, and estimated the risk of dementia. RESULTS:Before controlling for multiple pollutants, hazard ratios with 95% confidence intervals for the overall population were 7.63 (7.28-7.99, p <0.001) at a 0.51-ppm increases in total hydrocarbons, and 2.94 (2.82-3.05, p <0.001) at a 0.32-ppm increases in non-methane hydrocarbons. The highest adjusted hazard ratios for different multiple-pollutant models of each targeted pollutant were statistically significant (p <0.001) for all patients: 11.52 (10.86-12.24) for total hydrocarbons and 9.73 (9.18-10.32) for non-methane hydrocarbons. CONCLUSION:Our findings suggest that total hydrocarbons and non-methane hydrocarbons may be contributing to dementia development.

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http://hdl.handle.net/10453/141209