Formulation and evaluation of solid self-microemulsifying drug delivery system for azilsartan medoxomil

Madan, JR; Patil, K; Awasthi, R; Dua, K

Formulation and evaluation of solid self-microemulsifying drug delivery system for azilsartan medoxomil

Madan, JR Patil, K Awasthi, R Dua, K

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Publication Type:: Journal Article
Citation:: International Journal of Polymeric Materials and Polymeric Biomaterials, 2019
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Madan, JR	en_US
dc.contributor.author	Patil, K	en_US
dc.contributor.author	Awasthi, R	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.date.accessioned	2020-06-11T06:51:10Z
dc.date.accessioned	2020-06-11T06:51:11Z
dc.date.available	2020-06-11T06:51:10Z
dc.date.available	2020-06-11T06:51:11Z
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	International Journal of Polymeric Materials and Polymeric Biomaterials, 2019	en_US
dc.identifier.issn	0091-4037	en_US
dc.identifier.uri	http://hdl.handle.net/10453/141340
dc.description.abstract	© 2019, © 2019 Taylor & Francis Group, LLC. This study aimed to develop solid self-microemulsifying drug delivery system (S-SMEDDS) for solubility enhancement of azilsartan medoxomil (AZL). Ternary phase diagrams were constructed using surfactant: co-surfactant at 1:0, 1:1, 1:2 and 2:1 ratios. Initially, the oils, surfactants and co-surfactants were screened. The drug–soya lecithin complexes were prepared and characterized for complexation percentage, complex solubility, and partition coefficient. The liquid SMEDDS were prepared and evaluated for thermodynamic stability, self-emulsification efficiency and time, viscosity, size and polydispersibility index, zeta potential, drug loading, and in vitro dissolution. Further, the solid SMEDDS were formulated and evaluated for morphological characterization, and thermal behavior. The solid SMEDDS were filled with hard gelatin capsule and accessed for in vitro drug release profile. S-SMEDDS containing Syloid® XDP 3150 had highest adsorption capacity. Self-emulsification time, drug loading and percentage transmittance were 25 ± 1.23 s, 99.20 ± 0.11% and 99.3 ± 0.1%, respectively. Particle size, polydispersibility index and zeta potential were 201.0 nm, 0.544 and -19.7 mV, respectively. S-SMEDDS had good flow property, spontaneous self-microemulsification property and improved in vitro dissolution profile of AZL when compared to pure AZL.	en_US
dc.relation.ispartof	International Journal of Polymeric Materials and Polymeric Biomaterials	en_US
dc.relation.isbasedon	10.1080/00914037.2019.1695206	en_US
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject.classification	Polymers	en_US
dc.title	Formulation and evaluation of solid self-microemulsifying drug delivery system for azilsartan medoxomil	en_US
dc.type	Journal Article
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	recently_added	*
pubs.publication-status	Published	en_US

Abstract:

© 2019, © 2019 Taylor & Francis Group, LLC. This study aimed to develop solid self-microemulsifying drug delivery system (S-SMEDDS) for solubility enhancement of azilsartan medoxomil (AZL). Ternary phase diagrams were constructed using surfactant: co-surfactant at 1:0, 1:1, 1:2 and 2:1 ratios. Initially, the oils, surfactants and co-surfactants were screened. The drug–soya lecithin complexes were prepared and characterized for complexation percentage, complex solubility, and partition coefficient. The liquid SMEDDS were prepared and evaluated for thermodynamic stability, self-emulsification efficiency and time, viscosity, size and polydispersibility index, zeta potential, drug loading, and in vitro dissolution. Further, the solid SMEDDS were formulated and evaluated for morphological characterization, and thermal behavior. The solid SMEDDS were filled with hard gelatin capsule and accessed for in vitro drug release profile. S-SMEDDS containing Syloid® XDP 3150 had highest adsorption capacity. Self-emulsification time, drug loading and percentage transmittance were 25 ± 1.23 s, 99.20 ± 0.11% and 99.3 ± 0.1%, respectively. Particle size, polydispersibility index and zeta potential were 201.0 nm, 0.544 and -19.7 mV, respectively. S-SMEDDS had good flow property, spontaneous self-microemulsification property and improved in vitro dissolution profile of AZL when compared to pure AZL.

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http://hdl.handle.net/10453/141340