Role of Ion-Phospholipid Interactions in Zwitterionic Phospholipid Bilayer Ion Permeation.

Deplazes, E; Tafalla, BD; Cranfield, CG; Garcia, A

Role of Ion-Phospholipid Interactions in Zwitterionic Phospholipid Bilayer Ion Permeation.

Deplazes, E

Tafalla, BD Cranfield, CG Garcia, A

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Publisher:: American Chemical Society (ACS)
Publication Type:: Journal Article
Citation:: The journal of physical chemistry letters, 2020, pp. 6353-6358
Issue Date:: 2020-07-23

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Field	Value	Language
dc.contributor.author	Deplazes, E https://orcid.org/0000-0003-2052-5536
dc.contributor.author	Tafalla, BD
dc.contributor.author	Cranfield, CG
dc.contributor.author	Garcia, A https://orcid.org/0000-0002-1159-4567
dc.date.accessioned	2020-07-30T03:35:33Z
dc.date.available	2021-08-12T19:00:53Z
dc.date.issued	2020-07-23
dc.identifier.citation	The journal of physical chemistry letters, 2020, pp. 6353-6358
dc.identifier.issn	1948-7185
dc.identifier.issn	1948-7185
dc.identifier.uri	http://hdl.handle.net/10453/141926
dc.description.abstract	Despite the central role of Na+ and K+ in physiological processes, it is still unclear whether they interact or alter the physical properties of simple zwitterionic phospholipid bilayers at physiologically relevant concentrations. Here we report a difference in membrane permeability between Na+ and K+, as measured with electrical impedance spectroscopy and tethered bilayer lipid membranes. We reveal that the differences in membrane permeability originate from distinct ion coordination by carbonyl oxygens at the phospholipid-water interface, altering the propensity for bilayer pore formation. Molecular dynamics simulations showed differences in the coordination of Na+ and K+ at the phospholipid-water interface of zwitterionic phospholipid bilayers. The ability of Na+ to conscript more phospholipids with a greater number of coordinating interactions causes a higher localized energy barrier for pore formation. These results provide evidence that ion-specific interactions at the phospholipid-water interface can modulate the physical properties of zwitterionic phospholipid bilayers.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American Chemical Society (ACS)
dc.relation.ispartof	The journal of physical chemistry letters
dc.relation.isbasedon	10.1021/acs.jpclett.0c01479
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	02 Physical Sciences, 03 Chemical Sciences
dc.title	Role of Ion-Phospholipid Interactions in Zwitterionic Phospholipid Bilayer Ion Permeation.
dc.type	Journal Article
utslib.location.activity	United States
utslib.for	02 Physical Sciences
utslib.for	03 Chemical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
dc.date.updated	2020-07-30T03:35:28Z
pubs.publication-status	Published

Abstract:

Despite the central role of Na+ and K+ in physiological processes, it is still unclear whether they interact or alter the physical properties of simple zwitterionic phospholipid bilayers at physiologically relevant concentrations. Here we report a difference in membrane permeability between Na+ and K+, as measured with electrical impedance spectroscopy and tethered bilayer lipid membranes. We reveal that the differences in membrane permeability originate from distinct ion coordination by carbonyl oxygens at the phospholipid-water interface, altering the propensity for bilayer pore formation. Molecular dynamics simulations showed differences in the coordination of Na+ and K+ at the phospholipid-water interface of zwitterionic phospholipid bilayers. The ability of Na+ to conscript more phospholipids with a greater number of coordinating interactions causes a higher localized energy barrier for pore formation. These results provide evidence that ion-specific interactions at the phospholipid-water interface can modulate the physical properties of zwitterionic phospholipid bilayers.

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http://hdl.handle.net/10453/141926