Evaluation of the sub-acute toxicity of Acacia catechu Willd seed extract in a Wistar albino rat model.

Thangavelu, L; Balusamy, SR; Shanmugam, R; Sivanesan, S; Devaraj, E; Rajagopalan, V; Veeraiyan, DN; Chellappan, DK; Dua, K; Kim, Y-J; Perumalsamy, H

Evaluation of the sub-acute toxicity of Acacia catechu Willd seed extract in a Wistar albino rat model.

Thangavelu, L Balusamy, SR Shanmugam, R Sivanesan, S Devaraj, E Rajagopalan, V Veeraiyan, DN Chellappan, DK Dua, K

Kim, Y-J Perumalsamy, H

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Publisher:: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Type:: Journal Article
Citation:: Regulatory toxicology and pharmacology : RTP, 2020, 113
Issue Date:: 2020-06

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Field	Value	Language
dc.contributor.author	Thangavelu, L
dc.contributor.author	Balusamy, SR
dc.contributor.author	Shanmugam, R
dc.contributor.author	Sivanesan, S
dc.contributor.author	Devaraj, E
dc.contributor.author	Rajagopalan, V
dc.contributor.author	Veeraiyan, DN
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Kim, Y-J
dc.contributor.author	Perumalsamy, H
dc.date.accessioned	2020-08-17T05:59:11Z
dc.date.available	2020-03-04
dc.date.available	2020-08-17T05:59:11Z
dc.date.issued	2020-06
dc.identifier.citation	Regulatory toxicology and pharmacology : RTP, 2020, 113
dc.identifier.issn	0273-2300
dc.identifier.issn	1096-0295
dc.identifier.uri	http://hdl.handle.net/10453/142150
dc.description.abstract	Acacia catechu (A. catechu) or Khair (Hindi) is used in several herbal preparations in the Ayurvedic system of medicine in India. Traditionally, this drug is beneficial against several gastrointestinal and stomach related ailments, and leprosy. The present investigation was carried out to evaluate the sub-acute oral toxicity of the ethanolic extract of A. catechu seeds in Wistar albino rats. Results obtained from the quantitative chemical analysis of A. catechu seed extract were compared with commercially available standards. A. catechu seed extract was administered orally at the doses of 250, 500 and 1000 mg/kg b.w. daily for 28 days. General behavior, bodyweight and mortality were examined during the entire study period. At the end of 28 days, hematological and biochemical parameters along with the relative organ weights were determined. It was observed that the extract did not induce death or any significant changes in the body weight, relative weight of vital organs and in hematological parameters for up to a dose of 1000 mg/kg. The oral administration of the plant extract did not produce any significant changes in the levels of glucose. In addition, there were no significant changes in the activity of both hepatotoxic and nephrotoxic marker enzymes in the serum. Oral administration of A. catechu also did not produce any significant changes in the levels of oxidative markers. Furthermore, the findings from the biochemical studies were, well corroborated with the histological findings.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartof	Regulatory toxicology and pharmacology : RTP
dc.relation.isbasedon	10.1016/j.yrtph.2020.104640
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Toxicology
dc.title	Evaluation of the sub-acute toxicity of Acacia catechu Willd seed extract in a Wistar albino rat model.
dc.type	Journal Article
utslib.citation.volume	113
utslib.location.activity	Netherlands
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-08-17T05:58:57Z
pubs.publication-status	Published
pubs.volume	113

Abstract:

Acacia catechu (A. catechu) or Khair (Hindi) is used in several herbal preparations in the Ayurvedic system of medicine in India. Traditionally, this drug is beneficial against several gastrointestinal and stomach related ailments, and leprosy. The present investigation was carried out to evaluate the sub-acute oral toxicity of the ethanolic extract of A. catechu seeds in Wistar albino rats. Results obtained from the quantitative chemical analysis of A. catechu seed extract were compared with commercially available standards. A. catechu seed extract was administered orally at the doses of 250, 500 and 1000 mg/kg b.w. daily for 28 days. General behavior, bodyweight and mortality were examined during the entire study period. At the end of 28 days, hematological and biochemical parameters along with the relative organ weights were determined. It was observed that the extract did not induce death or any significant changes in the body weight, relative weight of vital organs and in hematological parameters for up to a dose of 1000 mg/kg. The oral administration of the plant extract did not produce any significant changes in the levels of glucose. In addition, there were no significant changes in the activity of both hepatotoxic and nephrotoxic marker enzymes in the serum. Oral administration of A. catechu also did not produce any significant changes in the levels of oxidative markers. Furthermore, the findings from the biochemical studies were, well corroborated with the histological findings.

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