Inflammatory properties of diet mediate the effect of depressive symptoms on Framingham risk score in men and women: Results from the National Health and Nutrition Examination Survey (2007-2014).

Kang, J; Moser, DK; Biddle, MJ; Lennie, TA; Smyth, SS; Vsevolozhskaya, OA

Inflammatory properties of diet mediate the effect of depressive symptoms on Framingham risk score in men and women: Results from the National Health and Nutrition Examination Survey (2007-2014).

Kang, J Moser, DK Biddle, MJ Lennie, TA Smyth, SS Vsevolozhskaya, OA

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Nutrition research (New York, N.Y.), 2020, 74, pp. 78-86
Issue Date:: 2020-02

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Field	Value	Language
dc.contributor.author	Kang, J
dc.contributor.author	Moser, DK
dc.contributor.author	Biddle, MJ
dc.contributor.author	Lennie, TA
dc.contributor.author	Smyth, SS
dc.contributor.author	Vsevolozhskaya, OA
dc.date.accessioned	2020-08-19T06:09:03Z
dc.date.available	2019-11-07
dc.date.available	2020-08-19T06:09:03Z
dc.date.issued	2020-02
dc.identifier.citation	Nutrition research (New York, N.Y.), 2020, 74, pp. 78-86
dc.identifier.issn	0271-5317
dc.identifier.issn	1879-0739
dc.identifier.uri	http://hdl.handle.net/10453/142234
dc.description.abstract	Depression is common in patients with cardiovascular disease (CVD) and associated with inflammation. Inflammation contributes to the development of CVD and can be modulated by diet. However, the role of inflammatory properties of diet in the relationship between depressive symptoms and CVD risk is not well understood. We hypothesized that the inflammatory properties of diet mediate the relationship between depressive symptoms and CVD risk in men and women. Cross-sectional data collected by the National Health and Nutrition Examination Survey (2007-2014) were used for the study. Depressive symptoms scores, inflammatory properties of diet, and CVD risk were measured by the Patient Health Questionnaire-9 (PHQ-9), the Dietary Inflammatory Index (DII), and the Framingham risk score (FRS), respectively. Generalized linear models were used for the mediation analysis. There were significant differences in the proportions of men and women in the depressed group (PHQ-9 ≥ 10; 5.24 ± 0.65% vs 9.36 ± 0.87%, P < .001) and high CVD risk group (FRS >20%; 16.47 ± 0.79% vs 6.03 ± 0.32%, P < .001). The DII partially mediated the relationship between depressive symptoms and CVD risk in men (indirect effect: 0.06, P = .010) but fully mediated the relationship between depressive symptoms and CVD risk in women (indirect effect: 0.10, P < .001). These findings confirmed our hypothesis that inflammatory properties of diet at least partially mediate the relationship between depressive symptoms and CVD risk in men and women. Our findings suggest that interventions designed to reduce depressive symptoms should contain strategies to reduce pro-inflammatory and increase anti-inflammatory properties of diet to decrease CVD risk.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Nutrition research (New York, N.Y.)
dc.relation.isbasedon	10.1016/j.nutres.2019.11.008
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1111 Nutrition and Dietetics
dc.subject.classification	Nutrition & Dietetics
dc.title	Inflammatory properties of diet mediate the effect of depressive symptoms on Framingham risk score in men and women: Results from the National Health and Nutrition Examination Survey (2007-2014).
dc.type	Journal Article
utslib.citation.volume	74
utslib.location.activity	United States
utslib.for	1111 Nutrition and Dietetics
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-08-19T06:08:32Z
pubs.publication-status	Published
pubs.volume	74

Abstract:

Depression is common in patients with cardiovascular disease (CVD) and associated with inflammation. Inflammation contributes to the development of CVD and can be modulated by diet. However, the role of inflammatory properties of diet in the relationship between depressive symptoms and CVD risk is not well understood. We hypothesized that the inflammatory properties of diet mediate the relationship between depressive symptoms and CVD risk in men and women. Cross-sectional data collected by the National Health and Nutrition Examination Survey (2007-2014) were used for the study. Depressive symptoms scores, inflammatory properties of diet, and CVD risk were measured by the Patient Health Questionnaire-9 (PHQ-9), the Dietary Inflammatory Index (DII), and the Framingham risk score (FRS), respectively. Generalized linear models were used for the mediation analysis. There were significant differences in the proportions of men and women in the depressed group (PHQ-9 ≥ 10; 5.24 ± 0.65% vs 9.36 ± 0.87%, P < .001) and high CVD risk group (FRS >20%; 16.47 ± 0.79% vs 6.03 ± 0.32%, P < .001). The DII partially mediated the relationship between depressive symptoms and CVD risk in men (indirect effect: 0.06, P = .010) but fully mediated the relationship between depressive symptoms and CVD risk in women (indirect effect: 0.10, P < .001). These findings confirmed our hypothesis that inflammatory properties of diet at least partially mediate the relationship between depressive symptoms and CVD risk in men and women. Our findings suggest that interventions designed to reduce depressive symptoms should contain strategies to reduce pro-inflammatory and increase anti-inflammatory properties of diet to decrease CVD risk.

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http://hdl.handle.net/10453/142234