Genus Blepharis (Acanthaceae): A review of ethnomedicinally used species, and their phytochemistry and pharmacological activities.

Dirar, AI; Devkota, AA; Kunwar, RM; Paudel, KR; Belwal, T; Gupta, G; Chellappan, DK; Hansbro, PM; Dua, K; Devkota, HP

Genus Blepharis (Acanthaceae): A review of ethnomedicinally used species, and their phytochemistry and pharmacological activities.

Dirar, AI Devkota, AA Kunwar, RM Paudel, KR Belwal, T Gupta, G Chellappan, DK Hansbro, PM Dua, K

Devkota, HP

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Journal of ethnopharmacology, 2020, pp. 113255
Issue Date:: 2020-08-13

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Field	Value	Language
dc.contributor.author	Dirar, AI
dc.contributor.author	Devkota, AA
dc.contributor.author	Kunwar, RM
dc.contributor.author	Paudel, KR
dc.contributor.author	Belwal, T
dc.contributor.author	Gupta, G
dc.contributor.author	Chellappan, DK
dc.contributor.author	Hansbro, PM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Devkota, HP
dc.date.accessioned	2020-09-09T23:55:08Z
dc.date.available	2020-08-04
dc.date.available	2020-09-09T23:55:08Z
dc.date.issued	2020-08-13
dc.identifier.citation	Journal of ethnopharmacology, 2020, pp. 113255
dc.identifier.issn	0378-8741
dc.identifier.issn	1872-7573
dc.identifier.uri	http://hdl.handle.net/10453/142601
dc.description.abstract	ETHNOPHARMACOLOGICAL RELEVANCE:Blepharis is an Afro-Asiatic genus belonging to the family Acanthaceae. It comprises 126 species that occur in arid and semi-arid habitats. Some species of Blepharis are used in traditional medicines in different countries mainly for their anti-inflammatory, would healing activities along with treatment of gastrointestinal disorders and bone fractures. AIM OF THE REVIEW:The present review aims to collate and analyze the available data and information on distribution, traditional uses, chemical constituents and pharmacological activities of Blepharis. METHODS:Scientific information of genus Blepharis was retrieved from the online bibliographic databases like MEDLINE/PubMed, SciFinder, Web of Science and Google Scholar and secondary resources including books and proceedings. RESULTS:Seven species of Blepharis were found to be reported frequently as useful in folklore in Asian and African countries. B. maderaspatensis was found to be widely used in Indian traditional medicines whereas the B. ciliaris and B. edulis were common in folklore of Egypt, Jordan, and Arabia. Active phytochemicals of Blepharis are flavonoids from B. ciliaris, alkaloids from B. sindica, phenolic acid derivatives, and phytosterols, and derivatives of hydroxamic acids from B. edulis resulted in possessing diverse biological properties such as anti-microbial, anti-inflammatory, and anti-cancer. CONCLUSION:Various species of Blepharis were found to be used in traditional medicine systems in African and Asian countries. Few of these species were studied for their bioactive chemical constituents however the activity guided isolation studies are not performed. Similarly, detailed pharmacological studies in animal models to explore their mechanism of action are also not reported. Future studies should focus on these aspects related to the medicinally used species of Blepharis. The detailed and comprehensive comparative analysis presented here gives valuable information of the currently used Blepharis species and pave the way to investigate other useful species of Blepharis pertaining to ethnobotany, phytochemistry and discovery of new drugs.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Journal of ethnopharmacology
dc.relation.isbasedon	10.1016/j.jep.2020.113255
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0607 Plant Biology, 1104 Complementary and Alternative Medicine, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.title	Genus Blepharis (Acanthaceae): A review of ethnomedicinally used species, and their phytochemistry and pharmacological activities.
dc.type	Journal Article
utslib.location.activity	Ireland
utslib.for	0607 Plant Biology
utslib.for	1104 Complementary and Alternative Medicine
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2020-09-09T23:55:01Z
pubs.publication-status	Published

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE:Blepharis is an Afro-Asiatic genus belonging to the family Acanthaceae. It comprises 126 species that occur in arid and semi-arid habitats. Some species of Blepharis are used in traditional medicines in different countries mainly for their anti-inflammatory, would healing activities along with treatment of gastrointestinal disorders and bone fractures. AIM OF THE REVIEW:The present review aims to collate and analyze the available data and information on distribution, traditional uses, chemical constituents and pharmacological activities of Blepharis. METHODS:Scientific information of genus Blepharis was retrieved from the online bibliographic databases like MEDLINE/PubMed, SciFinder, Web of Science and Google Scholar and secondary resources including books and proceedings. RESULTS:Seven species of Blepharis were found to be reported frequently as useful in folklore in Asian and African countries. B. maderaspatensis was found to be widely used in Indian traditional medicines whereas the B. ciliaris and B. edulis were common in folklore of Egypt, Jordan, and Arabia. Active phytochemicals of Blepharis are flavonoids from B. ciliaris, alkaloids from B. sindica, phenolic acid derivatives, and phytosterols, and derivatives of hydroxamic acids from B. edulis resulted in possessing diverse biological properties such as anti-microbial, anti-inflammatory, and anti-cancer. CONCLUSION:Various species of Blepharis were found to be used in traditional medicine systems in African and Asian countries. Few of these species were studied for their bioactive chemical constituents however the activity guided isolation studies are not performed. Similarly, detailed pharmacological studies in animal models to explore their mechanism of action are also not reported. Future studies should focus on these aspects related to the medicinally used species of Blepharis. The detailed and comprehensive comparative analysis presented here gives valuable information of the currently used Blepharis species and pave the way to investigate other useful species of Blepharis pertaining to ethnobotany, phytochemistry and discovery of new drugs.

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http://hdl.handle.net/10453/142601