Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT.

Meng, X; Zhang, B; Yi, Y; Cheng, H; Wang, B; Liu, Y; Gong, T; Yang, W; Yao, Y; Wang, H; Bu, W

Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT.

Meng, X Zhang, B Yi, Y Cheng, H Wang, B

Liu, Y Gong, T Yang, W Yao, Y Wang, H Bu, W

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Publisher:: AMER CHEMICAL SOC
Publication Type:: Journal Article
Citation:: Nano letters, 2020, 20, (4), pp. 2522-2529
Issue Date:: 2020-04

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Field	Value	Language
dc.contributor.author	Meng, X
dc.contributor.author	Zhang, B
dc.contributor.author	Yi, Y
dc.contributor.author	Cheng, H
dc.contributor.author	Wang, B https://orcid.org/0000-0002-8701-3896
dc.contributor.author	Liu, Y
dc.contributor.author	Gong, T
dc.contributor.author	Yang, W
dc.contributor.author	Yao, Y
dc.contributor.author	Wang, H
dc.contributor.author	Bu, W
dc.date.accessioned	2020-10-22T03:19:42Z
dc.date.available	2021-05-18T19:00:35Z
dc.date.issued	2020-04
dc.identifier.citation	Nano letters, 2020, 20, (4), pp. 2522-2529
dc.identifier.issn	1530-6984
dc.identifier.issn	1530-6992
dc.identifier.uri	http://hdl.handle.net/10453/143462
dc.description.abstract	Photothermal therapy (PTT) is an efficient approach for cancer treatment. However, accurately monitoring the spatial distribution of photothermal transducing agents (PTAs) and mapping the real-time temperature change in tumor and peritumoral normal tissue remain a huge challenge. Here, we propose an innovative strategy to integrate T1-MRI for precisely tracking PTAs with magnetic resonance temperature imaging (MRTI) for real-time monitoring temperature change in vivo during PTT. NaBiF4: Gd@PDA@PEG nanomaterials were synthesized with favorable T1-weighted performance to target tumor and localize PTAs. The extremely weak susceptibility (1.04 × 10-6 emu g-1 Oe1-) of NaBiF4: Gd@PDA@PEG interferes with the local phase marginally, which maintains the capability of MRTI to dynamically record real-time temperature change in tumor and peritumoral normal tissue. The time resolution is 19 s per frame, and the detection precision of temperature change is approximately 0.1 K. The approach achieving PTT guided by multimode MRI holds significant potential for the clinical application.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	AMER CHEMICAL SOC
dc.relation.ispartof	Nano letters
dc.relation.isbasedon	10.1021/acs.nanolett.9b05267
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject.classification	Nanoscience & Nanotechnology
dc.title	Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT.
dc.type	Journal Article
utslib.citation.volume	20
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2020-10-22T03:19:10Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	20
utslib.citation.issue	4

Abstract:

Photothermal therapy (PTT) is an efficient approach for cancer treatment. However, accurately monitoring the spatial distribution of photothermal transducing agents (PTAs) and mapping the real-time temperature change in tumor and peritumoral normal tissue remain a huge challenge. Here, we propose an innovative strategy to integrate T1-MRI for precisely tracking PTAs with magnetic resonance temperature imaging (MRTI) for real-time monitoring temperature change in vivo during PTT. NaBiF4: Gd@PDA@PEG nanomaterials were synthesized with favorable T1-weighted performance to target tumor and localize PTAs. The extremely weak susceptibility (1.04 × 10-6 emu g-1 Oe1-) of NaBiF4: Gd@PDA@PEG interferes with the local phase marginally, which maintains the capability of MRTI to dynamically record real-time temperature change in tumor and peritumoral normal tissue. The time resolution is 19 s per frame, and the detection precision of temperature change is approximately 0.1 K. The approach achieving PTT guided by multimode MRI holds significant potential for the clinical application.

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http://hdl.handle.net/10453/143462