Selectively-Packaged Proteins in Breast Cancer Extracellular Vesicles Involved in Metastasis.

Dalla, PV; Santos, J; Milthorpe, BK; Padula, MP

Selectively-Packaged Proteins in Breast Cancer Extracellular Vesicles Involved in Metastasis.

Dalla, PV Santos, J

Milthorpe, BK Padula, MP

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: International journal of molecular sciences, 2020, 21, (14)
Issue Date:: 2020-07-15

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Field	Value	Language
dc.contributor.author	Dalla, PV
dc.contributor.author	Santos, J https://orcid.org/0000-0003-4067-220X
dc.contributor.author	Milthorpe, BK
dc.contributor.author	Padula, MP
dc.date.accessioned	2020-11-02T05:51:34Z
dc.date.available	2020-07-13
dc.date.available	2020-11-02T05:51:34Z
dc.date.issued	2020-07-15
dc.identifier.citation	International journal of molecular sciences, 2020, 21, (14)
dc.identifier.issn	1422-0067
dc.identifier.issn	1422-0067
dc.identifier.uri	http://hdl.handle.net/10453/143692
dc.description.abstract	Cancer-derived extracellular vesicles are known to play a role in the progression of the disease. In this rapidly-growing field, there are many reports of phenotypic changes in cells following exposure to cancer-derived extracellular vesicles. This study examines the protein contents of vesicles derived from three well-known breast cancer cell lines, MCF-7, MDA-MB-231 and T47D, using peptide-centric LC-MS/MS and cytokine multiplex immunoassay analysis to understand the molecular basis of these changes. Through these techniques a large number of proteins within these vesicles were identified. A large proportion of these proteins are known to be important in cancer formation and progression and associated with cancer signaling, angiogenesis, metastasis and invasion and immune regulation. This highlights the importance of extracellular vesicles (EVs) in cancer communications and shows some of the mechanisms the vesicles use to assist in cancer progression.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	International journal of molecular sciences
dc.relation.isbasedon	10.3390/ijms21144990
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0399 Other Chemical Sciences, 0604 Genetics, 0699 Other Biological Sciences
dc.subject.classification	Chemical Physics
dc.title	Selectively-Packaged Proteins in Breast Cancer Extracellular Vesicles Involved in Metastasis.
dc.type	Journal Article
utslib.citation.volume	21
utslib.location.activity	Switzerland
utslib.for	0399 Other Chemical Sciences
utslib.for	0604 Genetics
utslib.for	0699 Other Biological Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2020-11-02T05:51:28Z
pubs.issue	14
pubs.publication-status	Published
pubs.volume	21
utslib.citation.issue	14

Abstract:

Cancer-derived extracellular vesicles are known to play a role in the progression of the disease. In this rapidly-growing field, there are many reports of phenotypic changes in cells following exposure to cancer-derived extracellular vesicles. This study examines the protein contents of vesicles derived from three well-known breast cancer cell lines, MCF-7, MDA-MB-231 and T47D, using peptide-centric LC-MS/MS and cytokine multiplex immunoassay analysis to understand the molecular basis of these changes. Through these techniques a large number of proteins within these vesicles were identified. A large proportion of these proteins are known to be important in cancer formation and progression and associated with cancer signaling, angiogenesis, metastasis and invasion and immune regulation. This highlights the importance of extracellular vesicles (EVs) in cancer communications and shows some of the mechanisms the vesicles use to assist in cancer progression.

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http://hdl.handle.net/10453/143692