Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys.

Lee, Q; Padula, MP; Pinello, N; Williams, SH; O'Rourke, MB; Fumagalli, MJ; Orkin, JD; Song, R; Shaban, B; Brenner, O; Pimanda, JE; Weninger, W; Souza, WMD; Melin, AD; Wong, JJ-L; Crim, MJ; Monette, S; Roediger, B; Jolly, CJ

Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys.

Lee, Q Padula, MP Pinello, N Williams, SH O'Rourke, MB Fumagalli, MJ Orkin, JD Song, R Shaban, B Brenner, O Pimanda, JE Weninger, W Souza, WMD Melin, AD Wong, JJ-L Crim, MJ Monette, S Roediger, B Jolly, CJ

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Publisher:: PUBLIC LIBRARY SCIENCE
Publication Type:: Journal Article
Citation:: PLoS pathogens, 2020, 16, (1)
Issue Date:: 2020-01-23

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Field	Value	Language
dc.contributor.author	Lee, Q
dc.contributor.author	Padula, MP
dc.contributor.author	Pinello, N
dc.contributor.author	Williams, SH
dc.contributor.author	O'Rourke, MB
dc.contributor.author	Fumagalli, MJ
dc.contributor.author	Orkin, JD
dc.contributor.author	Song, R
dc.contributor.author	Shaban, B
dc.contributor.author	Brenner, O
dc.contributor.author	Pimanda, JE
dc.contributor.author	Weninger, W
dc.contributor.author	Souza, WMD
dc.contributor.author	Melin, AD
dc.contributor.author	Wong, JJ-L
dc.contributor.author	Crim, MJ
dc.contributor.author	Monette, S
dc.contributor.author	Roediger, B
dc.contributor.author	Jolly, CJ
dc.date.accessioned	2021-01-08T00:28:59Z
dc.date.available	2019-12-08
dc.date.available	2021-01-08T00:28:59Z
dc.date.issued	2020-01-23
dc.identifier.citation	PLoS pathogens, 2020, 16, (1)
dc.identifier.issn	1553-7366
dc.identifier.issn	1553-7374
dc.identifier.uri	http://hdl.handle.net/10453/145205
dc.description.abstract	Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify "p10" and "p15" as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that many mammal chapparvoviruses are likely to be nephrotropic.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	PUBLIC LIBRARY SCIENCE
dc.relation.ispartof	PLoS pathogens
dc.relation.isbasedon	10.1371/journal.ppat.1008262
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0605 Microbiology, 1107 Immunology, 1108 Medical Microbiology
dc.subject.classification	Virology
dc.subject.mesh	Kidney
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Mice
dc.subject.mesh	Parvovirinae
dc.subject.mesh	Parvoviridae Infections
dc.subject.mesh	Rodent Diseases
dc.subject.mesh	Viral Proteins
dc.subject.mesh	Viral Tropism
dc.subject.mesh	Kidney
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Mice
dc.subject.mesh	Parvovirinae
dc.subject.mesh	Parvoviridae Infections
dc.subject.mesh	Rodent Diseases
dc.subject.mesh	Viral Proteins
dc.subject.mesh	Viral Tropism
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Kidney
dc.subject.mesh	Mice
dc.subject.mesh	Parvoviridae Infections
dc.subject.mesh	Parvovirinae
dc.subject.mesh	Rodent Diseases
dc.subject.mesh	Viral Proteins
dc.subject.mesh	Viral Tropism
dc.title	Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys.
dc.type	Journal Article
utslib.citation.volume	16
utslib.location.activity	United States
utslib.for	0605 Microbiology
utslib.for	1107 Immunology
utslib.for	1108 Medical Microbiology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2021-01-08T00:28:36Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	16
utslib.citation.issue	1

Abstract:

Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify "p10" and "p15" as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that many mammal chapparvoviruses are likely to be nephrotropic.

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http://hdl.handle.net/10453/145205