Endometrial lysosomal enzyme activity in ovulatory dysfunctional uterine bleeding, IUCD users and post-partum women

Wang, IY; Fraser, IS; Barsamian, SP; Manconi, F; Street, DJ; Cornillie, FJ; Russell, P

Endometrial lysosomal enzyme activity in ovulatory dysfunctional uterine bleeding, IUCD users and post-partum women

Wang, IY Fraser, IS Barsamian, SP Manconi, F Street, DJ

Cornillie, FJ Russell, P

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Publication Type:: Journal Article
Citation:: Molecular Human Reproduction, 2000, 6 (3), pp. 258 - 263
Issue Date:: 2000-01-01

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Field	Value	Language
dc.contributor.author	Wang, IY	en_US
dc.contributor.author	Fraser, IS	en_US
dc.contributor.author	Barsamian, SP	en_US
dc.contributor.author	Manconi, F	en_US
dc.contributor.author	Street, DJ https://orcid.org/0000-0002-4476-0656	en_US
dc.contributor.author	Cornillie, FJ	en_US
dc.contributor.author	Russell, P	en_US
dc.date.issued	2000-01-01	en_US
dc.identifier.citation	Molecular Human Reproduction, 2000, 6 (3), pp. 258 - 263	en_US
dc.identifier.issn	1360-9947	en_US
dc.identifier.uri	http://hdl.handle.net/10453/14531
dc.description.abstract	The aim of this study was to evaluate the role of lysosomal enzymes in excessively heavy menstruation by comparing women with menorrhagia due to dysfunctional bleeding or intrauterine contraceptive device (IUCD) use with those with normal menstrual periods or with amenorrhoea associated with breastfeeding. This was a prospective cohort investigation of the activity of four endometrial lysosomal enzymes in three contrasting groups: (i) women with ovulatory dysfunctional uterine bleeding and users of intrauterine contraceptive devices; (ii) breastfeeding post-partum women in whom there are long periods of amenorrhoea, particularly in the early months post-partum; and (iii) normal cycling women. It was found that the total activity of lysosomal enzymes, particularly acid phosphatase and N-acetyl-β-D- glucosaminidase, was markedly elevated (P<0.001) in IUCD-exposed endometrium, and endometrium from women with dysfunctional uterine bleeding when compared with endometrium from women with a history of entirely normal menstrual periods or that in post-partum breastfeeding women. The activity of α-L- fucosidase was moderately elevated in IUCD users (P < 0.05) and ovulatory dysfunctional uterine bleeding (P < 0.05), whereas αD-mannosidase activity was elevated in ovulatory dysfunctional uterine bleeding (P < 0.05), but decreased in IUCD users (P < 0.01). No significant differences were observed in the lysosomal enzyme activities of breastfeeding post-partum women and normal cycling women. These results show that total endometrial tissue activity of four lysosomal enzymes was substantially increased throughout the cycle in most circumstances in women with two different causes for increased menstrual bleeding. This suggests a contributory role to the increased bleeding.	en_US
dc.relation.ispartof	Molecular Human Reproduction	en_US
dc.relation.isbasedon	10.1093/molehr/6.3.258	en_US
dc.subject.classification	Obstetrics & Reproductive Medicine	en_US
dc.subject.mesh	Endometrium	en_US
dc.subject.mesh	Lysosomes	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Menorrhagia	en_US
dc.subject.mesh	Amenorrhea	en_US
dc.subject.mesh	Acid Phosphatase	en_US
dc.subject.mesh	alpha-L-Fucosidase	en_US
dc.subject.mesh	Acetylglucosaminidase	en_US
dc.subject.mesh	Mannosidases	en_US
dc.subject.mesh	alpha-Mannosidase	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Intrauterine Devices	en_US
dc.subject.mesh	Ovulation	en_US
dc.subject.mesh	Postpartum Period	en_US
dc.subject.mesh	Time Factors	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.title	Endometrial lysosomal enzyme activity in ovulatory dysfunctional uterine bleeding, IUCD users and post-partum women	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	6	en_US
utslib.for	1402 Applied Economics	en_US
utslib.for	140302 Econometric and Statistical Methods	en_US
utslib.for	010401 Applied Statistics	en_US
utslib.for	0606 Physiology	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Business
pubs.organisational-group	/University of Technology Sydney/Strength - CHERE - Centre for Health Economics Research and Evaluation
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	6	en_US

Abstract:

The aim of this study was to evaluate the role of lysosomal enzymes in excessively heavy menstruation by comparing women with menorrhagia due to dysfunctional bleeding or intrauterine contraceptive device (IUCD) use with those with normal menstrual periods or with amenorrhoea associated with breastfeeding. This was a prospective cohort investigation of the activity of four endometrial lysosomal enzymes in three contrasting groups: (i) women with ovulatory dysfunctional uterine bleeding and users of intrauterine contraceptive devices; (ii) breastfeeding post-partum women in whom there are long periods of amenorrhoea, particularly in the early months post-partum; and (iii) normal cycling women. It was found that the total activity of lysosomal enzymes, particularly acid phosphatase and N-acetyl-β-D- glucosaminidase, was markedly elevated (P<0.001) in IUCD-exposed endometrium, and endometrium from women with dysfunctional uterine bleeding when compared with endometrium from women with a history of entirely normal menstrual periods or that in post-partum breastfeeding women. The activity of α-L- fucosidase was moderately elevated in IUCD users (P < 0.05) and ovulatory dysfunctional uterine bleeding (P < 0.05), whereas αD-mannosidase activity was elevated in ovulatory dysfunctional uterine bleeding (P < 0.05), but decreased in IUCD users (P < 0.01). No significant differences were observed in the lysosomal enzyme activities of breastfeeding post-partum women and normal cycling women. These results show that total endometrial tissue activity of four lysosomal enzymes was substantially increased throughout the cycle in most circumstances in women with two different causes for increased menstrual bleeding. This suggests a contributory role to the increased bleeding.

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http://hdl.handle.net/10453/14531