Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus.

Raynaud, C; Daher, W; Roquet-Banères, F; Johansen, MD; Stec, J; Onajole, OK; Ordway, D; Kozikowski, AP; Kremer, L

Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus.

Raynaud, C Daher, W Roquet-Banères, F Johansen, MD Stec, J Onajole, OK Ordway, D Kozikowski, AP Kremer, L

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Publisher:: AMER SOC MICROBIOLOGY
Publication Type:: Journal Article
Citation:: Antimicrobial agents and chemotherapy, 2020, 64, (5)
Issue Date:: 2020-04-21

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Field	Value	Language
dc.contributor.author	Raynaud, C
dc.contributor.author	Daher, W
dc.contributor.author	Roquet-Banères, F
dc.contributor.author	Johansen, MD
dc.contributor.author	Stec, J
dc.contributor.author	Onajole, OK
dc.contributor.author	Ordway, D
dc.contributor.author	Kozikowski, AP
dc.contributor.author	Kremer, L
dc.date.accessioned	2021-02-04T02:26:14Z
dc.date.available	2020-02-06
dc.date.available	2021-02-04T02:26:14Z
dc.date.issued	2020-04-21
dc.identifier.citation	Antimicrobial agents and chemotherapy, 2020, 64, (5)
dc.identifier.issn	0066-4804
dc.identifier.issn	1098-6596
dc.identifier.uri	http://hdl.handle.net/10453/145805
dc.description.abstract	New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
dc.format	Electronic-Print
dc.language	eng
dc.publisher	AMER SOC MICROBIOLOGY
dc.relation.ispartof	Antimicrobial agents and chemotherapy
dc.relation.isbasedon	10.1128/aac.02548-19
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	0605 Microbiology, 1108 Medical Microbiology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Microbiology
dc.title	Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus.
dc.type	Journal Article
utslib.citation.volume	64
utslib.location.activity	United States
utslib.for	0605 Microbiology
utslib.for	1108 Medical Microbiology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2021-02-04T02:26:06Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	64
utslib.citation.issue	5

Abstract:

New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.

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http://hdl.handle.net/10453/145805