Using Mediation Analysis to Understand How Treatments for Paediatric Pain Work: A Systematic Review and Recommendations for Future Research

Leake, HB; Moseley, GL; Stanton, TR; Heathcote, LC; Pate, JW; Wewege, MA; Lee, H

Using Mediation Analysis to Understand How Treatments for Paediatric Pain Work: A Systematic Review and Recommendations for Future Research

Leake, HB Moseley, GL Stanton, TR Heathcote, LC Pate, JW Wewege, MA Lee, H

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Children, 8, (2), pp. 147-147

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Field	Value	Language
dc.contributor.author	Leake, HB
dc.contributor.author	Moseley, GL
dc.contributor.author	Stanton, TR
dc.contributor.author	Heathcote, LC
dc.contributor.author	Pate, JW
dc.contributor.author	Wewege, MA
dc.contributor.author	Lee, H
dc.date.accessioned	2021-02-17T00:45:13Z
dc.date.available	2021-02-17T00:45:13Z
dc.identifier.citation	Children, 8, (2), pp. 147-147
dc.identifier.issn	2227-9067
dc.identifier.uri	http://hdl.handle.net/10453/146162
dc.description.abstract	<jats:p>Clinicians have an increasing number of evidence-based interventions to treat pain in youth. Mediation analysis offers a way of investigating how interventions work, by examining the extent to which an intermediate variable, or mediator, explains the effect of an intervention. This systematic review examined studies that used mediation analysis to investigate mechanisms of interventions on pain-relevant outcomes for youth (3–18 years) with acute or chronic pain, and provides recommendations for future mediation research in this field. We searched five electronic databases for clinical trials or observational longitudinal studies that included a comparison group and conducted mediation analyses of interventions on youth and assessed pain outcomes. We found six studies (N = 635), which included a total of 53 mediation models examining how interventions affect pain-relevant outcomes for youth. Five studies were secondary analyses of randomized controlled trials of psychological interventions for chronic pain; one was a longitudinal observational study of morphine for acute pain. The pain conditions studied were irritable bowel syndrome, functional abdominal pain, juvenile fibromyalgia, mixed chronic pain, and post-operative pain. Fourteen putative mediators were tested, of which three partially mediated treatment effect; seven did not significantly mediate treatment effect and four had mixed results. Methodological and reporting limitations were common. There are substantial gaps in the field with respect to investigating, and therefore understanding, how paediatric interventions work.</jats:p>
dc.language	en
dc.publisher	MDPI AG
dc.relation.ispartof	Children
dc.relation.isbasedon	10.3390/children8020147
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Using Mediation Analysis to Understand How Treatments for Paediatric Pain Work: A Systematic Review and Recommendations for Future Research
dc.type	Journal Article
utslib.citation.volume	8
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Physiotherapy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
utslib.copyright.status	open_access	*
dc.date.updated	2021-02-17T00:45:10Z
pubs.issue	2
pubs.publication-status	Published online
pubs.volume	8
utslib.citation.issue	2

Abstract:

Clinicians have an increasing number of evidence-based interventions to treat pain in youth. Mediation analysis offers a way of investigating how interventions work, by examining the extent to which an intermediate variable, or mediator, explains the effect of an intervention. This systematic review examined studies that used mediation analysis to investigate mechanisms of interventions on pain-relevant outcomes for youth (3–18 years) with acute or chronic pain, and provides recommendations for future mediation research in this field. We searched five electronic databases for clinical trials or observational longitudinal studies that included a comparison group and conducted mediation analyses of interventions on youth and assessed pain outcomes. We found six studies (N = 635), which included a total of 53 mediation models examining how interventions affect pain-relevant outcomes for youth. Five studies were secondary analyses of randomized controlled trials of psychological interventions for chronic pain; one was a longitudinal observational study of morphine for acute pain. The pain conditions studied were irritable bowel syndrome, functional abdominal pain, juvenile fibromyalgia, mixed chronic pain, and post-operative pain. Fourteen putative mediators were tested, of which three partially mediated treatment effect; seven did not significantly mediate treatment effect and four had mixed results. Methodological and reporting limitations were common. There are substantial gaps in the field with respect to investigating, and therefore understanding, how paediatric interventions work.

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http://hdl.handle.net/10453/146162