ZIF-8 Modified Polypropylene Membrane: A Biomimetic Cell Culture Platform with a View to the Improvement of Guided Bone Regeneration.
Ejeian, F
Razmjou, A
Nasr-Esfahani, MH
Mohammad, M
Karamali, F
Ebrahimi Warkiani, M
Asadnia, M
Chen, V
- Publisher:
- Informa UK Limited
- Publication Type:
- Journal Article
- Citation:
- International journal of nanomedicine, 2020, 15, pp. 10029-10043
- Issue Date:
- 2020-01
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Ejeian, F | |
dc.contributor.author | Razmjou, A | |
dc.contributor.author | Nasr-Esfahani, MH | |
dc.contributor.author | Mohammad, M | |
dc.contributor.author | Karamali, F | |
dc.contributor.author |
Ebrahimi Warkiani, M https://orcid.org/0000-0002-4184-1944 |
|
dc.contributor.author | Asadnia, M | |
dc.contributor.author | Chen, V | |
dc.date.accessioned | 2021-03-01T05:40:33Z | |
dc.date.available | 2020-10-26 | |
dc.date.available | 2021-03-01T05:40:33Z | |
dc.date.issued | 2020-01 | |
dc.identifier.citation | International journal of nanomedicine, 2020, 15, pp. 10029-10043 | |
dc.identifier.issn | 1176-9114 | |
dc.identifier.issn | 1178-2013 | |
dc.identifier.uri | http://hdl.handle.net/10453/146567 | |
dc.description.abstract | <h4>Purpose</h4>Despite the significant advances in modeling of biomechanical aspects of cell microenvironment, it remains a major challenge to precisely mimic the physiological condition of the particular cell niche. Here, the metal-organic frameworks (MOFs) have been introduced as a feasible platform for multifactorial control of cell-substrate interaction, given the wide range of physical and mechanical properties of MOF materials and their structural flexibility.<h4>Results</h4>In situ crystallization of zeolitic imidazolate framework-8 (ZIF-8) on the polydopamine (PDA)-modified membrane significantly raised surface energy, wettability, roughness, and stiffness of the substrate. This modulation led to an almost twofold increment in the primary attachment of dental pulp stem cells (DPSCs) compare to conventional plastic culture dishes. The findings indicate that polypropylene (PP) membrane modified by PDA/ZIF-8 coating effectively supports the growth and proliferation of DPSCs at a substantial rate. Further analysis also displayed the exaggerated multilineage differentiation of DPSCs with amplified level of autocrine cell fate determination signals, like <i>BSP1, BMP2, PPARG, FABP4, ACAN</i>, and <i>COL2A</i>. Notably, osteogenic markers were dramatically overexpressed (more than 100-folds rather than tissue culture plate) in response to biomechanical characteristics of the ZIF-8 layer.<h4>Conclusion</h4>Hence, surface modification of cell culture platforms with MOF nanostructures proposed as a powerful nanomedical approach for selectively guiding stem cells for tissue regeneration. In particular, PP/PDA/ZIF-8 membrane presented ideal characteristics for using as a barrier membrane for guided bone regeneration (GBR) in periodontal tissue engineering. | |
dc.format | Electronic-eCollection | |
dc.language | eng | |
dc.publisher | Informa UK Limited | |
dc.relation.ispartof | International journal of nanomedicine | |
dc.relation.isbasedon | 10.2147/ijn.s269169 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0601 Biochemistry and Cell Biology, 1007 Nanotechnology, 1115 Pharmacology and Pharmaceutical Sciences | |
dc.subject.classification | Nanoscience & Nanotechnology | |
dc.subject.mesh | Stem Cells | |
dc.subject.mesh | Zeolites | |
dc.subject.mesh | Polypropylenes | |
dc.subject.mesh | Indoles | |
dc.subject.mesh | Polymers | |
dc.subject.mesh | Membranes, Artificial | |
dc.subject.mesh | Guided Tissue Regeneration | |
dc.subject.mesh | Cell Culture Techniques | |
dc.subject.mesh | Bone Regeneration | |
dc.subject.mesh | Cell Differentiation | |
dc.subject.mesh | Osteogenesis | |
dc.subject.mesh | Stem Cells | |
dc.subject.mesh | Zeolites | |
dc.subject.mesh | Polypropylenes | |
dc.subject.mesh | Indoles | |
dc.subject.mesh | Polymers | |
dc.subject.mesh | Membranes, Artificial | |
dc.subject.mesh | Guided Tissue Regeneration | |
dc.subject.mesh | Cell Culture Techniques | |
dc.subject.mesh | Bone Regeneration | |
dc.subject.mesh | Cell Differentiation | |
dc.subject.mesh | Osteogenesis | |
dc.subject.mesh | Bone Regeneration | |
dc.subject.mesh | Cell Culture Techniques | |
dc.subject.mesh | Cell Differentiation | |
dc.subject.mesh | Guided Tissue Regeneration | |
dc.subject.mesh | Indoles | |
dc.subject.mesh | Membranes, Artificial | |
dc.subject.mesh | Osteogenesis | |
dc.subject.mesh | Polymers | |
dc.subject.mesh | Polypropylenes | |
dc.subject.mesh | Stem Cells | |
dc.subject.mesh | Zeolites | |
dc.title | ZIF-8 Modified Polypropylene Membrane: A Biomimetic Cell Culture Platform with a View to the Improvement of Guided Bone Regeneration. | |
dc.type | Journal Article | |
utslib.citation.volume | 15 | |
utslib.location.activity | New Zealand | |
utslib.for | 0601 Biochemistry and Cell Biology | |
utslib.for | 1007 Nanotechnology | |
utslib.for | 1115 Pharmacology and Pharmaceutical Sciences | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
utslib.copyright.status | open_access | * |
pubs.consider-herdc | false | |
dc.date.updated | 2021-03-01T05:40:25Z | |
pubs.publication-status | Published | |
pubs.volume | 15 |
Abstract:
Purpose
Despite the significant advances in modeling of biomechanical aspects of cell microenvironment, it remains a major challenge to precisely mimic the physiological condition of the particular cell niche. Here, the metal-organic frameworks (MOFs) have been introduced as a feasible platform for multifactorial control of cell-substrate interaction, given the wide range of physical and mechanical properties of MOF materials and their structural flexibility.Results
In situ crystallization of zeolitic imidazolate framework-8 (ZIF-8) on the polydopamine (PDA)-modified membrane significantly raised surface energy, wettability, roughness, and stiffness of the substrate. This modulation led to an almost twofold increment in the primary attachment of dental pulp stem cells (DPSCs) compare to conventional plastic culture dishes. The findings indicate that polypropylene (PP) membrane modified by PDA/ZIF-8 coating effectively supports the growth and proliferation of DPSCs at a substantial rate. Further analysis also displayed the exaggerated multilineage differentiation of DPSCs with amplified level of autocrine cell fate determination signals, like BSP1, BMP2, PPARG, FABP4, ACAN, and COL2A. Notably, osteogenic markers were dramatically overexpressed (more than 100-folds rather than tissue culture plate) in response to biomechanical characteristics of the ZIF-8 layer.Conclusion
Hence, surface modification of cell culture platforms with MOF nanostructures proposed as a powerful nanomedical approach for selectively guiding stem cells for tissue regeneration. In particular, PP/PDA/ZIF-8 membrane presented ideal characteristics for using as a barrier membrane for guided bone regeneration (GBR) in periodontal tissue engineering.Please use this identifier to cite or link to this item:
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