Pulmonary Bioadhesive Drug Delivery Systems and Their Applications

Wadhwa, R; Bharathala, S; Aggarwal, T; Sehgal, N; Kumar, N; Gupta, G; Chellappan, DK; Maurya, PK; Pinto, TDJA; Collet, T; Dureja, H; Hansbro, PM; Dua, K

Pulmonary Bioadhesive Drug Delivery Systems and Their Applications

Wadhwa, R Bharathala, S Aggarwal, T Sehgal, N Kumar, N Gupta, G Chellappan, DK Maurya, PK Pinto, TDJA Collet, T Dureja, H Hansbro, PM Dua, K

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Publisher:: John Wiley & Sons
Publication Type:: Chapter
Citation:: Bioadhesives in Drug Delivery, 2020, 1, 1, pp. 371-390
Issue Date:: 2020-05-23

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Field	Value	Language
dc.contributor.author	Wadhwa, R
dc.contributor.author	Bharathala, S
dc.contributor.author	Aggarwal, T
dc.contributor.author	Sehgal, N
dc.contributor.author	Kumar, N
dc.contributor.author	Gupta, G
dc.contributor.author	Chellappan, DK
dc.contributor.author	Maurya, PK
dc.contributor.author	Pinto, TDJA
dc.contributor.author	Collet, T
dc.contributor.author	Dureja, H
dc.contributor.author	Hansbro, PM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2021-03-03T03:52:35Z
dc.date.available	2021-03-03T03:52:35Z
dc.date.issued	2020-05-23
dc.identifier.citation	Bioadhesives in Drug Delivery, 2020, 1, 1, pp. 371-390
dc.identifier.isbn	1119640199
dc.identifier.isbn	9781119640196
dc.identifier.uri	http://hdl.handle.net/10453/146686
dc.description.abstract	Mucoadhesive based pulmonary drug delivery is an advanced novel intervention against several pulmonary diseases including asthma, chronic obstructive pulmonary disease, cystic fibrosis, etc. Mucoadhesive polymers are required to prolong the residence time of the drug to promote drug absorption via mucosa at a controlled rate in order to enhance the therapeutic effect. The drug interacts with the mucus layer and mucin molecules to prolong the residence time. Such a drug delivery system has low enzymatic degradation with improved patient compliance as its formulation depends on the use of a mucoadhesive and biocompatible polymer. Therefore, in this chapter, we have discussed the novel dosage formulations i.e. nanoparticles, liposomes, and microparticles for delivery via inhalation. However, there is an urgent need to study novel bioadhesive formulations with different polymeric materials and to identify many new drug molecules for pulmonary drug delivery.
dc.format.extent	12
dc.language	en
dc.publisher	John Wiley & Sons
dc.relation.ispartof	Bioadhesives in Drug Delivery
dc.relation.isbasedon	10.1002/9781119640240.ch12
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Pulmonary Bioadhesive Drug Delivery Systems and Their Applications
dc.type	Chapter
utslib.citation.volume	1
utslib.citation.edition	1
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-03-03T03:52:33Z
pubs.edition	1
pubs.place-of-publication	USA
pubs.publication-status	Published
pubs.volume	1
dc.location	USA

Abstract:

Mucoadhesive based pulmonary drug delivery is an advanced novel intervention against several pulmonary diseases including asthma, chronic obstructive pulmonary disease, cystic fibrosis, etc. Mucoadhesive polymers are required to prolong the residence time of the drug to promote drug absorption via mucosa at a controlled rate in order to enhance the therapeutic effect. The drug interacts with the mucus layer and mucin molecules to prolong the residence time. Such a drug delivery system has low enzymatic degradation with improved patient compliance as its formulation depends on the use of a mucoadhesive and biocompatible polymer. Therefore, in this chapter, we have discussed the novel dosage formulations i.e. nanoparticles, liposomes, and microparticles for delivery via inhalation. However, there is an urgent need to study novel bioadhesive formulations with different polymeric materials and to identify many new drug molecules for pulmonary drug delivery.

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http://hdl.handle.net/10453/146686