The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.

Chung, H-F; Pandeya, N; Dobson, AJ; Kuh, D; Brunner, EJ; Crawford, SL; Avis, NE; Gold, EB; Mitchell, ES; Woods, NF; Bromberger, JT; Thurston, RC; Joffe, H; Yoshizawa, T; Anderson, D; Mishra, GD

The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.

Chung, H-F Pandeya, N Dobson, AJ Kuh, D Brunner, EJ Crawford, SL Avis, NE Gold, EB Mitchell, ES Woods, NF Bromberger, JT Thurston, RC Joffe, H Yoshizawa, T Anderson, D

Mishra, GD

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Publisher:: Cambridge University Press (CUP)
Publication Type:: Journal Article
Citation:: Psychological medicine, 2018, 48, (15), pp. 2550-2561
Issue Date:: 2018-11

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Field	Value	Language
dc.contributor.author	Chung, H-F
dc.contributor.author	Pandeya, N
dc.contributor.author	Dobson, AJ
dc.contributor.author	Kuh, D
dc.contributor.author	Brunner, EJ
dc.contributor.author	Crawford, SL
dc.contributor.author	Avis, NE
dc.contributor.author	Gold, EB
dc.contributor.author	Mitchell, ES
dc.contributor.author	Woods, NF
dc.contributor.author	Bromberger, JT
dc.contributor.author	Thurston, RC
dc.contributor.author	Joffe, H
dc.contributor.author	Yoshizawa, T
dc.contributor.author	Anderson, D https://orcid.org/0000-0001-8996-9624
dc.contributor.author	Mishra, GD
dc.date.accessioned	2021-05-10T02:06:58Z
dc.date.available	2021-05-10T02:06:58Z
dc.date.issued	2018-11
dc.identifier.citation	Psychological medicine, 2018, 48, (15), pp. 2550-2561
dc.identifier.issn	0033-2917
dc.identifier.issn	1469-8978
dc.identifier.uri	http://hdl.handle.net/10453/148802
dc.description.abstract	<h4>Background</h4>Many women experience both vasomotor menopausal symptoms (VMS) and depressed mood at midlife, but little is known regarding the prospective bi-directional relationships between VMS and depressed mood and the role of sleep difficulties in both directions.<h4>Methods</h4>A pooled analysis was conducted using data from 21 312 women (median: 50 years, interquartile range 49-51) in eight studies from the InterLACE consortium. The degree of VMS, sleep difficulties, and depressed mood was self-reported and categorised as never, rarely, sometimes, and often (if reporting frequency) or never, mild, moderate, and severe (if reporting severity). Multivariable logistic regression models were used to examine the bi-directional associations adjusted for within-study correlation.<h4>Results</h4>At baseline, the prevalence of VMS (40%, range 13-62%) and depressed mood (26%, 8-41%) varied substantially across studies, and a strong dose-dependent association between VMS and likelihood of depressed mood was found. Over 3 years of follow-up, women with often/severe VMS at baseline were more likely to have subsequent depressed mood compared with those without VMS (odds ratios (OR) 1.56, 1.27-1.92). Women with often/severe depressed mood at baseline were also more likely to have subsequent VMS than those without depressed mood (OR 1.89, 1.47-2.44). With further adjustment for the degree of sleep difficulties at baseline, the OR of having a subsequent depressed mood associated with often/severe VMS was attenuated and no longer significant (OR 1.13, 0.90-1.40). Conversely, often/severe depressed mood remained significantly associated with subsequent VMS (OR 1.80, 1.38-2.34).<h4>Conclusions</h4>Difficulty in sleeping largely explained the relationship between VMS and subsequent depressed mood, but it had little impact on the relationship between depressed mood and subsequent VMS.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Cambridge University Press (CUP)
dc.relation.ispartof	Psychological medicine
dc.relation.isbasedon	10.1017/s0033291718000168
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1109 Neurosciences, 1117 Public Health and Health Services, 1701 Psychology
dc.subject.classification	Psychiatry
dc.subject.mesh	Vasomotor System
dc.subject.mesh	Humans
dc.subject.mesh	Hot Flashes
dc.subject.mesh	Prevalence
dc.subject.mesh	Data Interpretation, Statistical
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Depression
dc.subject.mesh	Comorbidity
dc.subject.mesh	Sweating
dc.subject.mesh	Menopause
dc.subject.mesh	Middle Aged
dc.subject.mesh	Female
dc.subject.mesh	Sleep Wake Disorders
dc.subject.mesh	Comorbidity
dc.subject.mesh	Data Interpretation, Statistical
dc.subject.mesh	Depression
dc.subject.mesh	Female
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Hot Flashes
dc.subject.mesh	Humans
dc.subject.mesh	Menopause
dc.subject.mesh	Middle Aged
dc.subject.mesh	Prevalence
dc.subject.mesh	Sleep Wake Disorders
dc.subject.mesh	Sweating
dc.subject.mesh	Vasomotor System
dc.title	The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.
dc.type	Journal Article
utslib.citation.volume	48
utslib.location.activity	England
utslib.for	1109 Neurosciences
utslib.for	1117 Public Health and Health Services
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2021-05-10T02:06:57Z
pubs.issue	15
pubs.publication-status	Published
pubs.volume	48
utslib.citation.issue	15

Abstract:

Background

Many women experience both vasomotor menopausal symptoms (VMS) and depressed mood at midlife, but little is known regarding the prospective bi-directional relationships between VMS and depressed mood and the role of sleep difficulties in both directions.

Methods

A pooled analysis was conducted using data from 21 312 women (median: 50 years, interquartile range 49-51) in eight studies from the InterLACE consortium. The degree of VMS, sleep difficulties, and depressed mood was self-reported and categorised as never, rarely, sometimes, and often (if reporting frequency) or never, mild, moderate, and severe (if reporting severity). Multivariable logistic regression models were used to examine the bi-directional associations adjusted for within-study correlation.

Results

At baseline, the prevalence of VMS (40%, range 13-62%) and depressed mood (26%, 8-41%) varied substantially across studies, and a strong dose-dependent association between VMS and likelihood of depressed mood was found. Over 3 years of follow-up, women with often/severe VMS at baseline were more likely to have subsequent depressed mood compared with those without VMS (odds ratios (OR) 1.56, 1.27-1.92). Women with often/severe depressed mood at baseline were also more likely to have subsequent VMS than those without depressed mood (OR 1.89, 1.47-2.44). With further adjustment for the degree of sleep difficulties at baseline, the OR of having a subsequent depressed mood associated with often/severe VMS was attenuated and no longer significant (OR 1.13, 0.90-1.40). Conversely, often/severe depressed mood remained significantly associated with subsequent VMS (OR 1.80, 1.38-2.34).

Conclusions

Difficulty in sleeping largely explained the relationship between VMS and subsequent depressed mood, but it had little impact on the relationship between depressed mood and subsequent VMS.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/148802