RNAi: Nature abhors a double-strand

Hutvágner, G; Zamore, PD

RNAi: Nature abhors a double-strand

Hutvágner, G

Zamore, PD

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Publication Type:: Journal Article
Citation:: Current Opinion in Genetics and Development, 2002, 12 (2), pp. 225 - 232
Issue Date:: 2002-04-01

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Field	Value	Language
dc.contributor.author	Hutvágner, G https://orcid.org/0000-0002-7231-9446	en_US
dc.contributor.author	Zamore, PD	en_US
dc.date.issued	2002-04-01	en_US
dc.identifier.citation	Current Opinion in Genetics and Development, 2002, 12 (2), pp. 225 - 232	en_US
dc.identifier.issn	0959-437X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/14888
dc.description.abstract	In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.	en_US
dc.relation.ispartof	Current Opinion in Genetics and Development	en_US
dc.relation.isbasedon	10.1016/S0959-437X(02)00290-3	en_US
dc.subject.classification	Developmental Biology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Endoribonucleases	en_US
dc.subject.mesh	Ribonuclease III	en_US
dc.subject.mesh	RNA Replicase	en_US
dc.subject.mesh	RNA, Double-Stranded	en_US
dc.subject.mesh	RNA, Messenger	en_US
dc.title	RNAi: Nature abhors a double-strand	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	12	en_US
utslib.for	0604 Genetics	en_US
dc.location.activity	ISI:000174356800015	en_US
dc.location.activity	Hatfield
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	12	en_US

Abstract:

In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/14888