Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis.

Ralph, N; Brown, L; McKillop, KL; Duff, J; Osborne, S; Terry, VR; Edward, K-L; King, R; Barui, E

Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis.

Ralph, N

Brown, L McKillop, KL Duff, J Osborne, S Terry, VR Edward, K-L King, R Barui, E

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Publisher:: BMC
Publication Type:: Journal Article
Citation:: Systematic reviews, 2020, 9, (1), pp. 37
Issue Date:: 2020-02-20

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Field	Value	Language
dc.contributor.author	Ralph, N https://orcid.org/0000-0002-7404-9996
dc.contributor.author	Brown, L
dc.contributor.author	McKillop, KL
dc.contributor.author	Duff, J
dc.contributor.author	Osborne, S
dc.contributor.author	Terry, VR
dc.contributor.author	Edward, K-L
dc.contributor.author	King, R
dc.contributor.author	Barui, E
dc.date.accessioned	2021-05-24T00:20:56Z
dc.date.available	2020-02-09
dc.date.available	2021-05-24T00:20:56Z
dc.date.issued	2020-02-20
dc.identifier.citation	Systematic reviews, 2020, 9, (1), pp. 37
dc.identifier.issn	2046-4053
dc.identifier.issn	2046-4053
dc.identifier.uri	http://hdl.handle.net/10453/149136
dc.description.abstract	<h4>Background</h4>Surgical site infections (SSIs) are among the most common healthcare-associated infections. Under-nutrition is an important risk factor for SSIs and can lead to delayed wound healing and longer hospital stays. Oral nutritional supplements are prescribed to reduce the risk of infection and improve health status, but data from randomised controlled trials (RCTs) have shown mixed results. Thus, the objective of our planned systematic review is to evaluate oral nutritional supplements on preventing SSIs in adult surgical patients METHODS: RCTs conducted in adult surgical patients who receive oral nutritional support will be included. The primary outcome will be the incidence of SSIs (within 30 days of surgery or within 90 days for joint replacement surgery). Secondary outcomes will be changes in nutritional status, mortality, health-related quality of life and costs. Literature searches will be conducted in several electronic databases (from inception onwards): MEDLINE, Embase, CINAHL and The Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching clinical trial registers and dissertation databases. Two reviewers will independently screen all citations, full-text articles and abstract data. The study methodological quality (or bias) will be appraised using the Cochrane risk of bias tool. If feasible, we will conduct random effects meta-analysis where appropriate.<h4>Discussion</h4>This systematic review will evaluate the evidence for pre- and post-surgical intervention with oral nutritional supplements in adults. Findings from this planned review may inform subsequent nutritional interventions for hospitalised patients who undergo surgery.<h4>Systematic review registration</h4>PROSPERO CRD42020140954.
dc.format	Electronic
dc.language	eng
dc.publisher	BMC
dc.relation.ispartof	Systematic reviews
dc.relation.isbasedon	10.1186/s13643-020-01293-x
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	11 Medical and Health Sciences
dc.subject.mesh	Humans
dc.subject.mesh	Surgical Wound Infection
dc.subject.mesh	Micronutrients
dc.subject.mesh	Nutritional Support
dc.subject.mesh	Nutrients
dc.subject.mesh	Humans
dc.subject.mesh	Micronutrients
dc.subject.mesh	Nutrients
dc.subject.mesh	Nutritional Support
dc.subject.mesh	Surgical Wound Infection
dc.title	Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	England
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.date.updated	2021-05-24T00:20:53Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	9
utslib.citation.issue	1

Abstract:

Background

Surgical site infections (SSIs) are among the most common healthcare-associated infections. Under-nutrition is an important risk factor for SSIs and can lead to delayed wound healing and longer hospital stays. Oral nutritional supplements are prescribed to reduce the risk of infection and improve health status, but data from randomised controlled trials (RCTs) have shown mixed results. Thus, the objective of our planned systematic review is to evaluate oral nutritional supplements on preventing SSIs in adult surgical patients METHODS: RCTs conducted in adult surgical patients who receive oral nutritional support will be included. The primary outcome will be the incidence of SSIs (within 30 days of surgery or within 90 days for joint replacement surgery). Secondary outcomes will be changes in nutritional status, mortality, health-related quality of life and costs. Literature searches will be conducted in several electronic databases (from inception onwards): MEDLINE, Embase, CINAHL and The Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching clinical trial registers and dissertation databases. Two reviewers will independently screen all citations, full-text articles and abstract data. The study methodological quality (or bias) will be appraised using the Cochrane risk of bias tool. If feasible, we will conduct random effects meta-analysis where appropriate.

Discussion

This systematic review will evaluate the evidence for pre- and post-surgical intervention with oral nutritional supplements in adults. Findings from this planned review may inform subsequent nutritional interventions for hospitalised patients who undergo surgery.

Systematic review registration

PROSPERO CRD42020140954.

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http://hdl.handle.net/10453/149136