The replication fork trap and termination of chromosome replication

Duggin, IG; Wake, RG; Bell, SD; Hill, TM

The replication fork trap and termination of chromosome replication

Duggin, IG

Wake, RG Bell, SD Hill, TM

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Publication Type:: Journal Article
Citation:: Molecular Microbiology, 2008, 70 (6), pp. 1323 - 1333
Issue Date:: 2008-12-01

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Field	Value	Language
dc.contributor.author	Duggin, IG https://orcid.org/0000-0003-4868-7350	en_US
dc.contributor.author	Wake, RG	en_US
dc.contributor.author	Bell, SD	en_US
dc.contributor.author	Hill, TM	en_US
dc.date.issued	2008-12-01	en_US
dc.identifier.citation	Molecular Microbiology, 2008, 70 (6), pp. 1323 - 1333	en_US
dc.identifier.issn	0950-382X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/14924
dc.description.abstract	Bacteria that have a circular chromosome with a bidirectional DNA replication origin are thought to utilize a 'replication fork trap' to control termination of replication. The fork trap is an arrangement of replication pause sites that ensures that the two replication forks fuse within the terminus region of the chromosome, approximately opposite the origin on the circular map. However, the biological significance of the replication fork trap has been mysterious, as its inactivation has no obvious consequence. Here we review the research that led to the replication fork trap theory, and we aim to integrate several recent findings that contribute towards an understanding of the physiological roles of the replication fork trap. Likely roles include the prevention of over-replication, and the optimization of post-replicative mechanisms of chromosome segregation, such as that involving FtsK in Escherichia coli. © 2008 The Authors.	en_US
dc.relation.ispartof	Molecular Microbiology	en_US
dc.relation.isbasedon	10.1111/j.1365-2958.2008.06500.x	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Chromosomes, Bacterial	en_US
dc.subject.mesh	Escherichia coli	en_US
dc.subject.mesh	Escherichia coli Proteins	en_US
dc.subject.mesh	Membrane Proteins	en_US
dc.subject.mesh	Chromosome Segregation	en_US
dc.subject.mesh	DNA Replication	en_US
dc.subject.mesh	Models, Genetic	en_US
dc.title	The replication fork trap and termination of chromosome replication	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	70	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	07 Agricultural and Veterinary Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	70	en_US

Abstract:

Bacteria that have a circular chromosome with a bidirectional DNA replication origin are thought to utilize a 'replication fork trap' to control termination of replication. The fork trap is an arrangement of replication pause sites that ensures that the two replication forks fuse within the terminus region of the chromosome, approximately opposite the origin on the circular map. However, the biological significance of the replication fork trap has been mysterious, as its inactivation has no obvious consequence. Here we review the research that led to the replication fork trap theory, and we aim to integrate several recent findings that contribute towards an understanding of the physiological roles of the replication fork trap. Likely roles include the prevention of over-replication, and the optimization of post-replicative mechanisms of chromosome segregation, such as that involving FtsK in Escherichia coli. © 2008 The Authors.

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http://hdl.handle.net/10453/14924