Pressure dependency of retinal arterial pulse wave velocity in the rat

Rezaeian, M; Georgevsky, D; Golzan, SM; Graham, S; Avolio, A; Butlin, M

Pressure dependency of retinal arterial pulse wave velocity in the rat

Rezaeian, M Georgevsky, D Golzan, SM Graham, S Avolio, A Butlin, M

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Publisher:: ATLANTIS PRESS
Publication Type:: Journal Article
Citation:: Artery Research, 2020, 26, (1), pp. 27-33
Issue Date:: 2020-03-01

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Field	Value	Language
dc.contributor.author	Rezaeian, M
dc.contributor.author	Georgevsky, D
dc.contributor.author	Golzan, SM
dc.contributor.author	Graham, S
dc.contributor.author	Avolio, A
dc.contributor.author	Butlin, M
dc.date.accessioned	2021-07-30T08:42:50Z
dc.date.available	2021-07-30T08:42:50Z
dc.date.issued	2020-03-01
dc.identifier.citation	Artery Research, 2020, 26, (1), pp. 27-33
dc.identifier.issn	1872-9312
dc.identifier.issn	1876-4401
dc.identifier.uri	http://hdl.handle.net/10453/150009
dc.description.abstract	© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V. This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/). Purpose: The retinal vasculature provides unique in vivo access to the microcirculation and presents the possibility of measuring small artery (retinal) stiffness using pulse wave velocity (PWV). This study investigates whether retinal artery PWV (rPWV) has a blood pressure (BP) dependency. Methods: Fundus videos from eight Sprague-Dawley rats aged 12 weeks were captured (Zeiss fundus microscope with high-speed camera, 125 fps, Optronis, Germany) simultaneously with aortic BP. Retinal artery diameter waveforms at proximal and distal sites were extracted and transit time calculated from the phase delay between frequency components (4–6 Hz, typical heart rate of rats) of the waveforms. rPWV was measured across a physiological range of mean arterial pressure (MAP): baseline (90–110 mmHg); 130 mmHg to baseline following systemic phenylephrine (PE) infusion (30 mg/kg/min); 130 mmHg to baseline during PE infusion with simultaneous inferior vena cava occlusion (VO); 70 mmHg to baseline following systemic sodium nitroprusside infusion; and 70 mmHg to baseline following VO. The correlation between retinal artery rPWV and BP was quantified. Results: There was a significant positive correlation between retinal artery rPWV and MAP as expected (0.19 mm/s/mmHg, R2 = 0.59, p < 0.001). There was a positive correlation between retinal and aortic PWV (R2 = 0.09, p = 0.03). Conclusion: The pressure dependency of the measured rPWV indicates the measure has utility in in vivo quantification of the impact on microvessels of cardiovascular diseases. To elucidate the predictive value of screening rPWV in systemic cardiovascular abnormalities, the relation needs to be investigated in humans.
dc.language	English
dc.publisher	ATLANTIS PRESS
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1105930
dc.relation	http://purl.org/au-research/grants/nhmrc/1105930
dc.relation.ispartof	Artery Research
dc.relation.isbasedon	10.2991/artres.k.200201.001
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences
dc.subject.classification	Cardiovascular System & Hematology
dc.title	Pressure dependency of retinal arterial pulse wave velocity in the rat
dc.type	Journal Article
utslib.citation.volume	26
utslib.for	1102 Cardiorespiratory Medicine and Haematology
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Orthoptics
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2021-07-30T08:42:49Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	26
utslib.citation.issue	1

Abstract:

© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V. This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/). Purpose: The retinal vasculature provides unique in vivo access to the microcirculation and presents the possibility of measuring small artery (retinal) stiffness using pulse wave velocity (PWV). This study investigates whether retinal artery PWV (rPWV) has a blood pressure (BP) dependency. Methods: Fundus videos from eight Sprague-Dawley rats aged 12 weeks were captured (Zeiss fundus microscope with high-speed camera, 125 fps, Optronis, Germany) simultaneously with aortic BP. Retinal artery diameter waveforms at proximal and distal sites were extracted and transit time calculated from the phase delay between frequency components (4–6 Hz, typical heart rate of rats) of the waveforms. rPWV was measured across a physiological range of mean arterial pressure (MAP): baseline (90–110 mmHg); 130 mmHg to baseline following systemic phenylephrine (PE) infusion (30 mg/kg/min); 130 mmHg to baseline during PE infusion with simultaneous inferior vena cava occlusion (VO); 70 mmHg to baseline following systemic sodium nitroprusside infusion; and 70 mmHg to baseline following VO. The correlation between retinal artery rPWV and BP was quantified. Results: There was a significant positive correlation between retinal artery rPWV and MAP as expected (0.19 mm/s/mmHg, R2 = 0.59, p < 0.001). There was a positive correlation between retinal and aortic PWV (R2 = 0.09, p = 0.03). Conclusion: The pressure dependency of the measured rPWV indicates the measure has utility in in vivo quantification of the impact on microvessels of cardiovascular diseases. To elucidate the predictive value of screening rPWV in systemic cardiovascular abnormalities, the relation needs to be investigated in humans.

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http://hdl.handle.net/10453/150009