Exploring sleep disturbance among adults with primary or secondary malignant brain tumors and their caregivers

Jeon, MS; Dhillon, HM; Koh, E-S; Nowak, AK; Hovey, E; Descallar, J; Miller, L; Marshall, NS; Agar, MR

Exploring sleep disturbance among adults with primary or secondary malignant brain tumors and their caregivers

Jeon, MS Dhillon, HM Koh, E-S Nowak, AK Hovey, E Descallar, J Miller, L Marshall, NS Agar, MR

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Publisher:: Oxford University Press (OUP)
Publication Type:: Journal Article
Citation:: Neuro-oncology practice, 2021, 8, (1), pp. 48-59
Issue Date:: 2021

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Field	Value	Language
dc.contributor.author	Jeon, MS
dc.contributor.author	Dhillon, HM
dc.contributor.author	Koh, E-S
dc.contributor.author	Nowak, AK
dc.contributor.author	Hovey, E
dc.contributor.author	Descallar, J
dc.contributor.author	Miller, L
dc.contributor.author	Marshall, NS
dc.contributor.author	Agar, MR
dc.date.accessioned	2021-10-08T01:31:43Z
dc.date.available	2021-10-08T01:31:43Z
dc.date.issued	2021
dc.identifier.citation	Neuro-oncology practice, 2021, 8, (1), pp. 48-59
dc.identifier.issn	2054-2577
dc.identifier.issn	2054-2585
dc.identifier.uri	http://hdl.handle.net/10453/150920
dc.description.abstract	Background Emerging evidence supports the clinical impact of sleep disturbance (SD) on cancer patients. This study aimed to determine the prevalence and predictors of SD in people with malignant brain tumors and caregivers, and explore any relationship between the patient-caregiver dyad’s sleep. Methods Eighty-one adults with primary malignant (91%) or metastatic (9%) brain tumors and their family caregivers (n = 44) completed a series of self-report questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index, and the drowsiness item of The MD Anderson Symptom Inventory-Brain Tumor in an Australian ambulatory neuro-oncology setting. Participants were grouped by the PSQI cutoff (SD > 5), and binary logistic regression analyses were performed to identify risk factors. Results Of patients, 53% reported SD and 15% of those clinically significant insomnia, and 27% reported moderate to severe daytime drowsiness. Whereas anxiety, depression, fatigue, pain, neurocognitive symptoms, and antiemetic use were higher in patients with SD, fatigue and KPS were strong predictors of SD. In caregivers, 55% reported poor sleep and 13% clinical insomnia. Anxiety, caregiver burden, and comorbid illness were significantly associated with caregivers’ SD. The individual’s SD did not affect the chance of the other member of the patient-caregiver dyad experiencing SD. Conclusions More than half the sample had sleep disturbance, which was linked to many concomitant symptoms, such as fatigue in patients and anxiety in caregivers, potentially contributing to distress and functional impairment. Understanding underlying mechanisms of SD, the potential use of these clinical predictors in care settings, and options for management is warranted.
dc.format	Electronic-eCollection
dc.language	en
dc.publisher	Oxford University Press (OUP)
dc.relation.ispartof	Neuro-oncology practice
dc.relation.isbasedon	10.1093/nop/npaa057
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Exploring sleep disturbance among adults with primary or secondary malignant brain tumors and their caregivers
dc.type	Journal Article
utslib.citation.volume	8
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-10-08T01:31:42Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	8
utslib.citation.issue	1

Abstract:

Background Emerging evidence supports the clinical impact of sleep disturbance (SD) on cancer patients. This study aimed to determine the prevalence and predictors of SD in people with malignant brain tumors and caregivers, and explore any relationship between the patient-caregiver dyad’s sleep. Methods Eighty-one adults with primary malignant (91%) or metastatic (9%) brain tumors and their family caregivers (n = 44) completed a series of self-report questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index, and the drowsiness item of The MD Anderson Symptom Inventory-Brain Tumor in an Australian ambulatory neuro-oncology setting. Participants were grouped by the PSQI cutoff (SD > 5), and binary logistic regression analyses were performed to identify risk factors. Results Of patients, 53% reported SD and 15% of those clinically significant insomnia, and 27% reported moderate to severe daytime drowsiness. Whereas anxiety, depression, fatigue, pain, neurocognitive symptoms, and antiemetic use were higher in patients with SD, fatigue and KPS were strong predictors of SD. In caregivers, 55% reported poor sleep and 13% clinical insomnia. Anxiety, caregiver burden, and comorbid illness were significantly associated with caregivers’ SD. The individual’s SD did not affect the chance of the other member of the patient-caregiver dyad experiencing SD. Conclusions More than half the sample had sleep disturbance, which was linked to many concomitant symptoms, such as fatigue in patients and anxiety in caregivers, potentially contributing to distress and functional impairment. Understanding underlying mechanisms of SD, the potential use of these clinical predictors in care settings, and options for management is warranted.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/150920