Formulation and evaluation of nano structured lipid carriers for intranasal delivery of buspirone hydrochloride

Mathure, D; Madan, JR; Ranpise, HA; Awasthi, R; Dua, K; Gujar, KN

Formulation and evaluation of nano structured lipid carriers for intranasal delivery of buspirone hydrochloride

Mathure, D Madan, JR Ranpise, HA Awasthi, R Dua, K

Gujar, KN

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Publisher:: A and V Publication
Publication Type:: Journal Article
Citation:: Research Journal of Pharmacy and Technology, 2021, 14, (2), pp. 585-593
Issue Date:: 2021-02-16

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Field	Value	Language
dc.contributor.author	Mathure, D
dc.contributor.author	Madan, JR
dc.contributor.author	Ranpise, HA
dc.contributor.author	Awasthi, R
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Gujar, KN
dc.date.accessioned	2021-10-11T05:31:42Z
dc.date.available	2021-10-11T05:31:42Z
dc.date.issued	2021-02-16
dc.identifier.citation	Research Journal of Pharmacy and Technology, 2021, 14, (2), pp. 585-593
dc.identifier.issn	0974-3618
dc.identifier.issn	0974-360X
dc.identifier.uri	http://hdl.handle.net/10453/150998
dc.description.abstract	The aim of this work was to formulate buspirone hydrochloride (BH) NLCs for intranasal administration to improve BH bioavailability. The BH loaded NLCs were prepared by hot high-pressure homogenization technique using Precirol ATO 5, olive oil and tween 80 as solid lipid, liquid lipid and surfactant, respectively. Carbopol 934P and HPMC K4M were used to convert NLCs dispersion into NLCs based in-situ nasal gelling solution to improve its mucoadhesive property for intranasal administration. A factorial design approach was used to study the effect of independent variable (amount of Precirol ATO 5 and olive oil) on the dependent variables (particle size and percentage entrapment efficiency (%EE). The optimized formulation was characterized for particle size, zeta potential, %EE, and surface morphology. Fourier transform infrared (FTIR) spectroscopy was used to study the possible BH-lipid complex formation. Further, viscosity determination, stability studies, in-vitro drug release, ex-vivo skin permeation studies and ex-vivo nasal toxicity studies of BH loaded NLCs nasal gelling solution were carried out. The BH loaded NLCs (batch F8) showed particle size of 111.8nm, %EE of 78.34% and zeta potential of-44.3mV. Scanning electron microscopy (SEM) confirmed spherical shape of NLCs. In vitro drug release and ex vivo skin permeation studies of BH loaded NLCs and BH loaded NLCs in-situ nasal gelling solution showed 71.26% drug permeation.
dc.language	en
dc.publisher	A and V Publication
dc.relation.ispartof	Research Journal of Pharmacy and Technology
dc.relation.isbasedon	10.5958/0974-360X.2021.00105.0
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Formulation and evaluation of nano structured lipid carriers for intranasal delivery of buspirone hydrochloride
dc.type	Journal Article
utslib.citation.volume	14
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-10-11T05:31:42Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	14
utslib.citation.issue	2

Abstract:

The aim of this work was to formulate buspirone hydrochloride (BH) NLCs for intranasal administration to improve BH bioavailability. The BH loaded NLCs were prepared by hot high-pressure homogenization technique using Precirol ATO 5, olive oil and tween 80 as solid lipid, liquid lipid and surfactant, respectively. Carbopol 934P and HPMC K4M were used to convert NLCs dispersion into NLCs based in-situ nasal gelling solution to improve its mucoadhesive property for intranasal administration. A factorial design approach was used to study the effect of independent variable (amount of Precirol ATO 5 and olive oil) on the dependent variables (particle size and percentage entrapment efficiency (%EE). The optimized formulation was characterized for particle size, zeta potential, %EE, and surface morphology. Fourier transform infrared (FTIR) spectroscopy was used to study the possible BH-lipid complex formation. Further, viscosity determination, stability studies, in-vitro drug release, ex-vivo skin permeation studies and ex-vivo nasal toxicity studies of BH loaded NLCs nasal gelling solution were carried out. The BH loaded NLCs (batch F8) showed particle size of 111.8nm, %EE of 78.34% and zeta potential of-44.3mV. Scanning electron microscopy (SEM) confirmed spherical shape of NLCs. In vitro drug release and ex vivo skin permeation studies of BH loaded NLCs and BH loaded NLCs in-situ nasal gelling solution showed 71.26% drug permeation.

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http://hdl.handle.net/10453/150998