Protein and peptide delivery to lungs by using advanced targeted drug delivery.

Chellappan, DK; Prasher, P; Saravanan, V; Vern Yee, VS; Wen Chi, WC; Wong, JW; Wong, JK; Wong, JT; Wan, W; Chellian, J; Molugulu, N; Prabu, SL; Ibrahim, R; Darmarajan, T; Candasamy, M; Singh, PK; Mishra, V; Khurana, N; Shastri, MD; Satija, S; Zacconi, FC; Chakraborty, A; Mehta, M; Gupta, PK; Dureja, H; Gulati, M; Singh, SK; Gupta, G; Jha, NK; George Oliver, BG; Dua, K

Protein and peptide delivery to lungs by using advanced targeted drug delivery.

Chellappan, DK Prasher, P Saravanan, V Vern Yee, VS Wen Chi, WC Wong, JW Wong, JK Wong, JT Wan, W Chellian, J Molugulu, N Prabu, SL Ibrahim, R Darmarajan, T Candasamy, M Singh, PK Mishra, V Khurana, N Shastri, MD Satija, S Zacconi, FC Chakraborty, A Mehta, M Gupta, PK Dureja, H Gulati, M Singh, SK Gupta, G Jha, NK George Oliver, BG Dua, K

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Chemico-biological interactions, 2021, pp. 109706
Issue Date:: 2021-10-15

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Field	Value	Language
dc.contributor.author	Chellappan, DK
dc.contributor.author	Prasher, P
dc.contributor.author	Saravanan, V
dc.contributor.author	Vern Yee, VS
dc.contributor.author	Wen Chi, WC
dc.contributor.author	Wong, JW
dc.contributor.author	Wong, JK
dc.contributor.author	Wong, JT
dc.contributor.author	Wan, W
dc.contributor.author	Chellian, J
dc.contributor.author	Molugulu, N
dc.contributor.author	Prabu, SL
dc.contributor.author	Ibrahim, R
dc.contributor.author	Darmarajan, T
dc.contributor.author	Candasamy, M
dc.contributor.author	Singh, PK
dc.contributor.author	Mishra, V
dc.contributor.author	Khurana, N
dc.contributor.author	Shastri, MD
dc.contributor.author	Satija, S
dc.contributor.author	Zacconi, FC
dc.contributor.author	Chakraborty, A
dc.contributor.author	Mehta, M
dc.contributor.author	Gupta, PK
dc.contributor.author	Dureja, H
dc.contributor.author	Gulati, M
dc.contributor.author	Singh, SK
dc.contributor.author	Gupta, G
dc.contributor.author	Jha, NK
dc.contributor.author	George Oliver, BG
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2021-11-03T02:06:51Z
dc.date.available	2021-10-13
dc.date.available	2021-11-03T02:06:51Z
dc.date.issued	2021-10-15
dc.identifier.citation	Chemico-biological interactions, 2021, pp. 109706
dc.identifier.issn	0009-2797
dc.identifier.issn	1872-7786
dc.identifier.uri	http://hdl.handle.net/10453/151324
dc.description.abstract	The challenges and difficulties associated with conventional drug delivery systems have led to the emergence of novel, advanced targeted drug delivery systems. Therapeutic drug delivery of proteins and peptides to the lungs is complicated owing to the large size and polar characteristics of the latter. Nevertheless, the pulmonary route has attracted great interest today among formulation scientists, as it has evolved into one of the important targeted drug delivery platforms for the delivery of peptides, and related compounds effectively to the lungs, primarily for the management and treatment of chronic lung diseases. In this review, we have discussed and summarized the current scenario and recent developments in targeted delivery of proteins and peptide-based drugs to the lungs. Moreover, we have also highlighted the advantages of pulmonary drug delivery over conventional drug delivery approaches for peptide-based drugs, in terms of efficacy, retention time and other important pharmacokinetic parameters. The review also highlights the future perspectives and the impact of targeted drug delivery on peptide-based drugs in the coming decade.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Chemico-biological interactions
dc.relation.isbasedon	10.1016/j.cbi.2021.109706
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Toxicology
dc.title	Protein and peptide delivery to lungs by using advanced targeted drug delivery.
dc.type	Journal Article
utslib.location.activity	Ireland
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2021-11-03T02:06:48Z
pubs.publication-status	Published

Abstract:

The challenges and difficulties associated with conventional drug delivery systems have led to the emergence of novel, advanced targeted drug delivery systems. Therapeutic drug delivery of proteins and peptides to the lungs is complicated owing to the large size and polar characteristics of the latter. Nevertheless, the pulmonary route has attracted great interest today among formulation scientists, as it has evolved into one of the important targeted drug delivery platforms for the delivery of peptides, and related compounds effectively to the lungs, primarily for the management and treatment of chronic lung diseases. In this review, we have discussed and summarized the current scenario and recent developments in targeted delivery of proteins and peptide-based drugs to the lungs. Moreover, we have also highlighted the advantages of pulmonary drug delivery over conventional drug delivery approaches for peptide-based drugs, in terms of efficacy, retention time and other important pharmacokinetic parameters. The review also highlights the future perspectives and the impact of targeted drug delivery on peptide-based drugs in the coming decade.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/151324